Involvement of nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tropisetron and ondansetron in mice forced swimming test and tail suspension test

2016 ◽  
Vol 780 ◽  
pp. 71-81 ◽  
Author(s):  
Arya Haj-Mirzaian ◽  
Nastaran Kordjazy ◽  
Shayan Amiri ◽  
Arvin Haj-Mirzaian ◽  
Hossien Amini-khoei ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Cyclic Guanosine Monophosphate ◽  
Forced Swimming ◽  
Guanosine Monophosphate ◽  
Tail Suspension ◽  
Swimming Test ◽  
Suspension Test

Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice

Neuroreport ◽  
2000 ◽  
Vol 11 (17) ◽  
pp. 3699-3702 ◽  
Author(s):  
Gisele de Lourdes da Silva ◽  
Andreza S. Matteussi ◽  
Adair Roberto S. dos Santos ◽  
João Batista Calixto ◽  
Ana Lúcia S. Rodrigues
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Tail Suspension ◽  
Swimming Test ◽  
Suspension Test

scholarly journals ANTI-DEPRESSANT EFFECT OF CEFTRIAXONE IN FORCED SWIMMING TEST AND IN TAIL SUSPENSION TEST IN MICE

2016 ◽  
Vol 8 (11) ◽  
pp. 191 ◽  
Author(s):  
Ajoy Borah ◽  
Binita Singha ◽  
Swopna Phukan
Keyword(s):  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Antidepressant Effect ◽  
Tail Suspension ◽  
Neuroprotective Effects ◽  
The Central Nervous System ◽  
Swimming Test ◽  
Suspension Test

Objective: Depression is a major psychiatric disorder affecting nearly 350 million people worldwide and imposes a substantial health burden on the society. Ceftriaxone has demonstrated neuroprotective effects in animals. It has also undergone trials as a treatment option for amyotrophic lateral sclerosis. This study was therefore undertaken to evaluate the antidepressant-like effect of ceftriaxone in mice.Methods: Ceftriaxone was administered at three different doses (0.130, 0.195 and 0.260g/kg) to Swiss albino mice of either sex by intra peritoneal (i. p.) route. The period of immobility in control and drug-treated mice were recorded in forced swimming test (FST) and tail suspension test (TST). The antidepressant effect of ceftriaxone indicated by the decrease in duration of immobility was compared to that of fluoxetine (0.020 g/kg, i. p.).Results: Ceftriaxone decreased the duration of immobility in mice. It showed a significant dose-dependent antidepressant effect. The antidepressant effect of 0.260g/kg of ceftriaxone was comparable to that of fluoxetine in the TST but not in the FST.Conclusion: The results of the present study indicate antidepressant activity of Ceftriaxone. The study shows that ceftriaxone has additional action on the central nervous system other than neuroprotection. Ceftriaxone therapy in cases of encephalomeningitis and in various cases of hemorrhages in the brain can, therefore, prevent the development of depression in future

scholarly journals Synthesis and anti-depressant evaluation of novel pyrazolone derivatives

2016 ◽  
Vol 11 (2) ◽  
pp. 558 ◽  
Author(s):  
Vijay Kumar Merugumolu ◽  
Revanasiddappa Bistuvalli Chandrashekara
Keyword(s):  
Forced Swimming Test ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Physical Parameters ◽  
Tail Suspension ◽  
Substituted Anilines ◽  
Standard Drug ◽  
Pyrazolone Derivatives ◽  
Swimming Test ◽  
Suspension Test

<p class="Abstract">Diazotization of substituted anilines with NaNO<sub>2</sub> and concentrated hydro-chloric acid at 0ºC gave the diazonium chlorides. Coupling of substituted aryl diazonium chlorides with ethyl acetoacetate in methanol gave ethyl-2-aryl-hydrazono-3-oxobutyrates (2a-h). Reaction of (2a-h) with naphthoic carbohydrazide (3) gave the title compounds pyrazolone derivatives (4a-h). The newly synthesized compounds were screened for their in vivo anti-depressant activity by tail suspension test and forced swimming test. Some of the tested compounds 4f, 4g showed very good activity when compared to the standard drug imipramine. The newly synthesized compounds were characterized by physical parameters and the structures were elucidated by spectral data.</p><p><strong>Video Clips</strong></p><p><a href="https://www.youtube.com/v/TZtb2a5u4CU">Forced swimming test</a>: 12 min 19 sec</p><p><a href="https://www.youtube.com/v/92mFRfBJgBw">Tail suspension test</a>: 8 min 5 sec</p><p> </p>

scholarly journals AN EXPERIMENTAL STUDY EVALUATING THE INFLUENCE OF BISPHOSPHONATES ON DEPRESSION PATTERNS IN SWISS ALBINO MICE AND WISTER RATS

2017 ◽  
Vol 9 (8) ◽  
pp. 187
Author(s):  
S. S. Torgal ◽  
Amitha N
Keyword(s):  
Adult Male ◽  
Forced Swimming Test ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Forced Swimming ◽  
Control Group ◽  
Tail Suspension ◽  
Swiss Albino Mice ◽  
Swimming Test ◽  
Suspension Test

Objective: Bisphosphonates are used for treating osteoporosis. Few studies have reported their effect on alterations in comorbid behaviour such as depression. Therefore, present study was performed to investigate the effects of bisphosphonate drugs on depression in adult male Wister rats and Swiss albino mice.Methods: The study was conducted on adult male Wister rats and Swiss albino mice, 36 of each type, equally divided into six groups. One group was classified as control group and the rest were treated as test groups. Initial photoperiod of 12 h was provided for acclimatization, prior to the start of the experiment. Drug administration was not performed in control group. Forced swimming test and tail suspension test were performed to investigate the antidepressant activity. Locomotor activity was performed to evaluate the action of drugs on the nervous system. Effects of the test drugs were compared with a standard drug—amitriptyline. Results were statistically evaluated by one-way analysis of variance followed by Bonferroni’s multiple comparison test. P≤0.05 was considered significant.Results: In forced swimming test, duration of immobility was significantly reduced in the standard and test drugs when compared to control group; however, it was not significant in all the four test groups as compared to that of amitriptyline-administered group (p>0.05). In tail suspension test, significant decrease (p<0.01) in the duration of immobility was observed with administration of drugs when compared to control group. Results of test groups were not found to be significant as compared to amitriptyline-treated group (p>0.05). Mean values of amitriptyline-, alendronate-, risedronate-, ibandronate-and etidronate-treated groups failed to show significant difference (p>0.05) when compared to control group suggesting homogeneity among the groups.Conclusion: Bisphosphonates appeared to have an antidepressant activity. More extensive research is required to substantiate and elucidate the role of bisphosphonates in behavioural disorders such as depression.

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