scholarly journals ASBMT Statement on Routine Prophylaxis for Central Nervous System Recurrence of Acute Lymphoblastic Leukemia following Allogeneic Hematopoietic Cell Transplantation

2019 ◽  
Vol 25 (3) ◽  
pp. e86-e88 ◽  
Author(s):  
Craig S. Sauter ◽  
Zachariah DeFilipp ◽  
Yoshihiro Inamoto ◽  
Laura Johnston ◽  
Arnon Nagler ◽  
...  
Author(s):  
Joshua Rosenblatt ◽  
Annie Leung ◽  
Emily Baneman ◽  
Risa Fuller ◽  
Sarah Taimur ◽  
...  

Abstract A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis prior to allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.


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