scholarly journals Implications and Management of Central Nervous System Involvement before Allogeneic Hematopoietic Cell Transplantation in Acute Lymphoblastic Leukemia

2016 ◽  
Vol 22 (3) ◽  
pp. 575-578 ◽  
Author(s):  
Ibrahim Aldoss ◽  
Monzr M. Al Malki ◽  
Tracey Stiller ◽  
Thai Cao ◽  
James F. Sanchez ◽  
...  
Author(s):  
Joshua Rosenblatt ◽  
Annie Leung ◽  
Emily Baneman ◽  
Risa Fuller ◽  
Sarah Taimur ◽  
...  

Abstract A patient with relapsed/refractory B-cell acute lymphoblastic leukemia developed babesiosis prior to allogeneic hematopoietic cell transplantation while on atovaquone for Pneumocystis jirovecii pneumonia prophylaxis. Despite receiving a prolonged course of atovaquone and azithromycin until whole blood Babesia microti DNA was no longer detected by polymerase chain reaction, her post-transplant course was complicated by relapsed babesiosis. We investigate the potential host and parasite characteristics causing relapsing/persistent infection.


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