scholarly journals Impact of Body Mass Index on Outcomes of Hematopoietic Stem Cell Transplantation in Adults

2019 ◽  
Vol 25 (3) ◽  
pp. 613-620 ◽  
Author(s):  
Kristine Doney ◽  
Kerry McMillen ◽  
Laura Buono ◽  
H. Joachim Deeg ◽  
Ted Gooley
Keyword(s):  
Body Mass Index ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Body Mass ◽  
Hematopoietic Stem

Pretransplant body mass index on outcomes of allogeneic hematopoietic stem cell transplantation

2019 ◽  
Vol 55 (6) ◽  
pp. 1175-1177
Author(s):  
Justin Tai ◽  
Matthew Buras ◽  
Jose Leis ◽  
Pierre Noel ◽  
Jeanne Palmer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Body Mass ◽  
Hematopoietic Stem

scholarly journals Obesity is correlated with poor outcome after allogeneic hematopoietic stem cell transplantation in patients with acute leukemia

2020 ◽  
Vol 50 (8) ◽  
pp. 889-896
Author(s):  
Jian Yu ◽  
Shangnao Lin ◽  
Yi Luo ◽  
Jimin Shi ◽  
Yamin Tan ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Confidence Interval ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Body Mass ◽  
Normal Weight ◽  
Hematopoietic Stem

Abstract Objective The relationship between body mass index and overall survival has been controversial in patients who suffered from hematological malignancies and underwent hematopoietic stem cell transplantation. Methods We collected the data of 686 acute leukemia patients who received only one allogeneic hematopoietic stem cell transplantation in our center from 2008 to 2017. Patients were divided into four groups (underweight, normal weight, overweight and obesity) according to their body mass index pre-hematopoietic stem cell transplantation. Results 56.4% of patients had normal body mass indices, 17.3% were underweight, 20.4% were overweight and 5.8% were with obesity. Concerning long-term follow-up, the probability of overall survival was significantly lower in overweight (P = 0.010) and patients with obesity (P = 0.065) as compared with normal weight patients, and no statistically significant difference between underweight and normal weight individuals (P = 0.810). The results demonstrated that higher body mass index was associated with poorer overall survival (hazard ratio: 1.79; 95% confidence interval: 1.33–2.40, P < 0.001) and shorter leukemia-free survival (hazard ratio: 1.78; 95% confidence interval: 1.35–2.34, P < 0.001). Additionally, patients exhibiting a higher body mass index were more likely to face the problem of relapse (30.6 vs 20.9%, P < 0.001). Furthermore, non-relapse mortality of patients with obesity was statistically higher than normal weight patients (22.5 vs 9.6%, P = 0.027). Besides, individuals with a higher abdominal girth had shorter survival (hazard ratio: 1.73; 95% confidence interval: 1.29–2.31, P < 0.001) and higher relapse rate (hazard ratio: 1.78; 95% confidence interval: 1.29–2.45, P = 0.001) as compared with those with a lower abdominal girth. Conclusion Our results indicate that obesity at pre-hematopoietic stem cell transplantation stage, whether characterized by higher body mass index or abdominal girth, is correlated with poorer outcome.

Effect of body mass index on outcomes of autologous hematopoietic stem cell transplantation.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e18004-e18004
Author(s):  
Sherilyn Alvaran Tuazon ◽  
Neil David Palmisiano ◽  
Scott W. Keith ◽  
Irina Kakhniashvili ◽  
Joanne E. Filicko-O'Hara
Keyword(s):  
Body Mass Index ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
Body Mass ◽  
Hematopoietic Stem

scholarly journals Cardiovascular risk and use of conicity index in patients submitted to autologous hematopoietic stem cell transplantation

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Suelyne Rodrigues de Morais ◽  
Ana Carolina Cavalcante Viana ◽  
Ana Filomena Camacho Santos Daltro ◽  
Priscila da Silva Mendonça
Keyword(s):  
Body Mass Index ◽  
Stem Cell ◽  
Cardiovascular Risk ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Stem Cell ◽  
The Body ◽  
Hematopoietic Stem ◽  
Conicity Index

ABSTRACT Objective To analyze the prevalence of overweight and the use of conicity index for cardiovascular risk assessment in individuals submitted to autologous hematopoietic stem cell transplantation. Methods The sample comprised 91 patients of both sexes, who underwent autologous hematopoietic stem cell transplantation from September 2008 to December 2013, aged 18 years or over. To determine the nutritional profile, we collected anthropometric data on weight, height, waist circumference upon hospital admission. The body mass index and the conicity index were calculated. Results A total of 91 patients diagnosed with multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma and other conditions were evaluated. The mean age was 43.5 (14.2) years, 63.7% were male. We verified that according to the body mass index, 63.7% were overweight and, according to waist circumference, 74.7% had a higher risk for cardiovascular diseases. According to the calculation of the conicity index, 92.3% of patients presented increased cardiovascular risk. Patients with multiple myeloma had a higher conicity index when compared to other patients (p<0.01). Conclusion This study revealed a high prevalence of overweight and cardiovascular risk. It should be noted that the conicity index was a good method to evaluate cardiovascular risk and that new studies using this index should be performed.

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