scholarly journals Feasibility and Impact of Digital Stories Intervention on Psychosocial Well-Being among Patients Undergoing Hematopoietic Cell Transplantation: A Pilot Study

2018 ◽  
Vol 24 (3) ◽  
pp. S262 ◽  
Author(s):  
Sunny Kim ◽  
Linda Larkey ◽  
Cody Meeker ◽  
Soojung Jo ◽  
Rafael Fonseca ◽  
...  
Keyword(s):  
Pilot Study ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Well Being ◽  
Hematopoietic Cell ◽  
Digital Stories

scholarly journals Long-term recovery after hematopoietic cell transplantation: predictors of quality-of-life concerns

Blood ◽  
2010 ◽  
Vol 115 (12) ◽  
pp. 2508-2519 ◽  
Author(s):  
F. Lennie Wong ◽  
Liton Francisco ◽  
Kayo Togawa ◽  
Alysia Bosworth ◽  
Mitzi Gonzales ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Chronic Gvhd ◽  
Well Being ◽  
Primary Diagnosis ◽  
Hematopoietic Cell ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

This prospective longitudinal study examined the quality of life (QOL) after hematopoietic cell transplantation (HCT) and identified risk factors of poor QOL in 312 adult autologous and allogeneic HCT patients. Physical, psychological, social, and spiritual well-being was assessed before HCT, 6 months, and 1, 2, and 3 years after HCT. For all HCT patients, physical QOL was stable from before to after HCT (P > .05); psychologic (P < .001), social (P < .001), and spiritual (P = .03) QOL improved at 6 months. Study noncompleters (because of illness or death) had worse QOL. Allogeneic patients reported worse physical and psychologic well-being (P < .05). Older patients reported worse physical but better social well-being regardless of HCT type (P < .05). Two or more domains were affected by race/ethnicity, household income, and education in autologous patients, and by body mass index (BMI), decline in BMI, primary diagnosis, and chronic graft-versus-host disease (GVHD) in allogeneic patients (P < .05). At 3 years, 74% of HCT patients were employed full or part time. Older autologous patients with lower pre-HCT income were less likely to work (P < .05); allogeneic patients with chronic GVHD were less likely to work (P = .002). Multidisciplinary efforts to identify and support vulnerable subgroups after HCT need to be developed.

scholarly journals Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor Study

Blood ◽  
2007 ◽  
Vol 110 (10) ◽  
pp. 3784-3792 ◽  
Author(s):  
Smita Bhatia ◽  
Liton Francisco ◽  
Andrea Carter ◽  
Can-Lan Sun ◽  
K. Scott Baker ◽  
...  
Keyword(s):  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Premature Death ◽  
Well Being ◽  
Marrow Transplant ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Standardized Mortality Ratio ◽  
Late Mortality ◽  
Relative Mortality

Abstract We assessed late mortality in 1479 individuals who had survived 2 or more years after allogeneic hematopoietic cell transplantation (HCT). Median age at HCT was 25.9 years and median length of follow-up was 9.5 years. The conditional survival probability at 15 years from HCT was 80.2% (SE = 1.9%) for those who were disease-free at entry into the cohort, and the relative mortality was 9.9 (95% confidence interval, 8.7-11.2). Relative mortality decreased with time from HCT, but remained significantly elevated at 15 years after HCT (standardized mortality ratio = 2.2). Relapse of primary disease (29%) and chronic graft-versus-host disease (cGVHD: 22%) were the leading causes of premature death. Nonrelapse-related mortality was increased among patients older than 18 years at HCT (18-45 years: relative risk [RR] = 1.7; 46+ years: RR = 3.7) and among those with cGVHD (RR = 2.7), and was lower among patients who received methotrexate for GVHD prophylaxis (RR = 0.5). HCT survivors were more likely to report difficulty in holding jobs (odds ratio [OR] = 13.9), and in obtaining health (OR = 7.1) or life (OR = 9.9) insurance compared with siblings. This study demonstrates that mortality rates remain twice as high as that of the general population among 15-year survivors of HCT, and that the survivors face challenges affecting their health and well-being.

scholarly journals From frail to fit after allogeneic hematopoietic cell transplantation: Scope of the problem and a strength-based solution

2019 ◽  
Author(s):  
Jason Sweetnam ◽  
Eric Twohey ◽  
Sasha Skendzel ◽  
John Stingle ◽  
Mukta Arora ◽  
...  
Keyword(s):  
Pilot Study ◽  
Strength Training ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Community Based ◽  
Allogeneic Hct ◽  
Long Term Survivors

AbstractBackgroundFrailty is a common but underdiagnosed syndrome among long-term survivors of allogeneic hematopoietic cell transplantation (HCT). Conditions such as malnutrition, fatigue, and weakness may suggest frailty despite patients not receiving a formal diagnosis. Furthermore, the optimal interventions to overcome frailty in long-term survivors of allogeneic HCT is not yet established.Patients and MethodsThis study consists of a retrospective and prospective component. First, we completed a retrospective review using diagnosis data from the electronic medical record to estimate the prevalence of components of frailty in 1077 recipients of allogeneic HCT through 5 years post-transplant. Second, we developed a community-based pilot study of strength training for long-term survivors of allogeneic HCT that addressed several common barriers exercise engagement and adherence. Four allogeneic HCT recipients (2 males, 2 females) and 4 controls (2 males, 2 females) completed the strength training pilot study, consisting of a baseline assessment, 10 weeks of personalized and supervised strength programming at least once weekly as a group, and an end-of-study assessment to measure progress in strength, body composition, and a standardized measure of self-efficacy.ResultsDespite a lack of a formal diagnosis, approximately 80% of HCT recipients in this series received a diagnosis of a component of frailty (weakness, fatigue, or malnutrition), and over 1/3 of HCT recipients had symptoms extending beyond 1 year. Over the course of the strength training pilot study, both pre-frail/frail allogeneic HCT recipients and healthy controls doubled their total strength, lost body fat, and gained muscle mass. Self-efficacy improved from baseline in allogeneic HCT recipients after the strength training pilot program.DiscussionBased upon the prevalence of frailty-related diagnoses among long-term survivors of HCT, a comprehensive mitigation strategy needs to be developed for this population. A community-based strength training program that includes a personalized component, a group setting, and caregiver/partner involvement appears feasible and overcomes several established barriers to exercise engagement and adherence.

Sign in / Sign up

Export Citation Format

Share Document