scholarly journals Consensus Report by Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplantation Consortium Joint Working Committees: Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents, Part 1: Focus on Investigations, Prophylaxis, and Specific Treatment

2017 ◽  
Vol 23 (11) ◽  
pp. 1817-1825 ◽  
Author(s):  
Rajinder P.S. Bajwa ◽  
Kris M. Mahadeo ◽  
Benjamin H. Taragin ◽  
Christopher C. Dvorak ◽  
Jennifer McArthur ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Supportive Care ◽  
Children And Adolescents ◽  
Marrow Transplantation ◽  
Specific Treatment ◽  
Occlusive Disease ◽  
Blood And Marrow Transplantation ◽  
Care Guidelines ◽  
Consensus Report

scholarly journals Experimental Models of Acute Lung Injury: their Advantages and Limitations

2020 ◽  
Vol 20 (3) ◽  
pp. 90-102
Author(s):  
D Mokra ◽  
P Mikolka ◽  
P Kosutova ◽  
A. Calkovska
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Animal Experiments ◽  
Specific Treatment ◽  
Severe Trauma ◽  
Therapeutic Strategies ◽  
Experimental Models ◽  
Lung Protective Ventilation ◽  
Novel Therapeutic Strategies ◽  
Complex Methods

AbstractAcute damage to the lung may originate from various direct and indirect reasons. Direct lung injury may be caused by pneumonia, near-drowning, aspiration, inhalation of toxic gases etc., while indirect lung injury is secondary, following any severe extra-pulmonary disease, e.g. sepsis, acute pancreatitis, or severe trauma. Due to a complex pathophysiology of the acute lung injury, the treatment is also extremely complicated and except for lung-protective ventilation there have been no specific treatment approaches recommended. An urgent need for a reliable and sufficiently effective treatment forces the researchers into testing novel therapeutic strategies. However, most of these determinations should be done in the laboratory conditions using animals. Complex methods of preparation of various experimental models of the acute lung injury has gradually developed within decades. Nowadays, there have been the models of direct, indirect, or mixed lung injury well established, as well as the models evoked by a combination of two triggering factors. Although the applicability of the results from animal experiments to patients might be limited by many factors, animal models are essential for understanding the patho-physiology of acute lung injury and provide an exceptional opportunity to search for novel therapeutical strategies.

Nanomedicine to advance the treatment of bacteria-induced acute lung injury

2021 ◽  
Author(s):  
Ruonan Su ◽  
Yu Zhang ◽  
Jiabin Zhang ◽  
Haixia Wang ◽  
Yun Luo ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Mortality Rate ◽  
Lung Injury ◽  
Supportive Care ◽  
Effective Treatment ◽  
High Mortality

Bacteria-induced acute lung injury (ALI) is associated with a high mortality rate due to the lack of an effective treatment. Patients often rely on supportive care such as low tidal...

Severe noninfectious acute lung injury in early phase of bone marrow transplantation

1998 ◽  
Vol 24 (5) ◽  
pp. 536-536 ◽  
Author(s):  
D. Gruson ◽  
G. Hilbert ◽  
F. Vargas ◽  
J. M. Boiron ◽  
A. Pigneux ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lung Injury ◽  
Bone Marrow Transplantation ◽  
Lung Injury ◽  
Marrow Transplantation ◽  
Early Phase

scholarly journals Luteolin Suppresses Inflammatory Mediator Expression by Blocking the Akt/NFκB Pathway in Acute Lung Injury Induced by Lipopolysaccharide in Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yi-Ching Li ◽  
Chung-Hsin Yeh ◽  
Ming-Ling Yang ◽  
Yu-Hsiang Kuan
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Inflammatory Responses ◽  
Specific Treatment ◽  
Severe Illness ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Protection Mechanism ◽  
Tissue Edema ◽  
Nfκb Pathway

Acute lung injury (ALI), instilled by lipopolysaccharide (LPS), is a severe illness with excessive mortality and has no specific treatment strategy. Luteolin is an anti-inflammatory flavonoid and widely distributed in the plants. Pretreatment with luteolin inhibited LPS-induced histological changes of ALI and lung tissue edema. In addition, LPS-induced inflammatory responses, including increased vascular permeability, tumor necrosis factor (TNF)-αand interleukin (IL)-6 production, and expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), were also reduced by luteolin in a concentration-dependent manner. Furthermore, luteolin suppressed activation of NFκB and its upstream molecular factor, Akt. These results suggest that the protection mechanism of luteolin is by inhibition of NFκB activation possibly via Akt.

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