scholarly journals Targeted Total Marrow Irradiation Using Three-Dimensional Image-Guided Tomographic Intensity-Modulated Radiation Therapy: An Alternative to Standard Total Body Irradiation

2006 ◽  
Vol 12 (3) ◽  
pp. 306-315 ◽  
Author(s):  
Jeffrey Y.C. Wong ◽  
An Liu ◽  
Timothy Schultheiss ◽  
Leslie Popplewell ◽  
Anthony Stein ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Total Body Irradiation ◽  
Three Dimensional ◽  
Intensity Modulated Radiation Therapy ◽  
Dimensional Image ◽  
Image Guided ◽  
Intensity Modulated ◽  
Total Marrow Irradiation ◽  
Total Body

scholarly journals Adequate target volume in total-body irradiation by intensity-modulated radiation therapy using helical tomotherapy: a simulation study

2016 ◽  
Vol 58 (2) ◽  
pp. 210-216 ◽  
Author(s):  
Ryosuke Takenaka ◽  
Akihiro Haga ◽  
Hideomi Yamashita ◽  
Keiichi Nakagawa
Keyword(s):  
Radiation Therapy ◽  
Total Body Irradiation ◽  
Intensity Modulated Radiation Therapy ◽  
Target Volume ◽  
The Body ◽  
High Fluence ◽  
Intensity Modulated ◽  
Small Set ◽  
Total Body ◽  
Set Up

Abstract Recently, intensity-modulated radiation therapy (IMRT) has been used for total-body irradiation (TBI). Since the planning target volume (PTV) for TBI includes the surrounding air, a dose prescription to the PTV provides high fluence to the body surface. Thus with just a small set-up error, the body might be exposed to a high-fluence beam. This study aims to assess which target volume should be prescribed the dose, such as a clinical target volume (CTV) with a margin, or a CTV that excludes the surface area of the skin. Three treatment plans were created for each patient: the 5-mm clipped plan (Plan A), the 0-mm margin plan (Plan B) and the 5-mm margin plan (Plan C). The CTV was the whole body. PTVs were the CTV with the exception of 5 mm from the skin surface in Plan A, equal to the CTV in Plan B, and the CTV with a 5 mm margin in Plan C. The prescribed dose was 12 Gy in six fractions. To assess the influence of the set-up error, dose distributions were simulated on computed tomography (CT) images shifted 2 pixels (= 4.296 mm), 5 pixels (= 10.74 mm) and 10 pixels (= 21.48 mm) in the lateral direction from the original CT. With a set-up error of 10.74 mm, V110% was 8.8%, 11.1% and 23.3% in Plans A, B and C, respectively. The prescription to the PTV containing the surrounding air can be paradoxically vulnerable to a high-dose as a consequence of a small set-up error.

scholarly journals A prosztatadaganatos betegek sugárterápiájának mikroköltség-számítása

2016 ◽  
Vol 157 (12) ◽  
pp. 461-468
Author(s):  
Antal Tamás Zemplényi ◽  
László Mangel ◽  
Zoltán Kaló ◽  
Dóra Endrei ◽  
Imre Boncz
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Three Dimensional ◽  
Intensity Modulated Radiation Therapy ◽  
Accounting System ◽  
Radiation Technology ◽  
Image Guided ◽  
Intensity Modulated ◽  
Delivery Times ◽  
Oncology Center

Introduction: Development of radiation technology provides new opportunities for the treatment of prostate cancer, but little is known about the costs of novel technologies. Aim: The aim of this analysis was to compare the costs of conventional three-dimensional radiation therapy to normal and hypofractionated intensity-modulated radiation therapy for the treatment of localized prostate cancer. Method: The cost-analysis was performed based on the data of a Hungarian oncology center from health care provider’s perspective. Irradiation time was assessed from the data of 100 fractions delivered in 20 patients. Unit costs for each component were calculated based on actual costs retrieved from the accounting system of the oncology center. Results: Average treatment delivery times were 14.5 minutes for three-dimensional radiation therapy, 16.2 minutes for intensity-modulated radiation therapy with image-guided and 14 minutes without image-guided method. Expected mean cost of patients undergoing conventional three-dimensional radiation therapy, normal and hypofractionated intensity-modulated radiation therapy were 619 000 HUF, 933 000 HUF and 692 000 HUF, respectively. Conclusions: Although normal and hypofractionated intensity-modulated radiation therapies have already been proven to be cost-effective, current reimbursement rates do not encourage healthcare providers to use the more effective therapy techniques. Orv. Hetil., 2016, 157(12), 461–468.

scholarly journals Safety of total body irradiation using intensity-modulated radiation therapy by helical tomotherapy in allogeneic hematopoietic stem cell transplantation: a prospective pilot study

2020 ◽  
Vol 61 (6) ◽  
pp. 969-976
Author(s):  
Tatsuya Konishi ◽  
Hiroaki Ogawa ◽  
Yuho Najima ◽  
Shinpei Hashimoto ◽  
Atsushi Wada ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Stem Cell ◽  
Pilot Study ◽  
Hematopoietic Stem Cell Transplantation ◽  
Total Body Irradiation ◽  
Helical Tomotherapy ◽  
Intensity Modulated Radiation Therapy ◽  
Hematopoietic Stem ◽  
Intensity Modulated ◽  
Total Body

Abstract Total body irradiation using intensity-modulated radiation therapy total body irradiation (IMRT-TBI) by helical tomotherapy in allogeneic hematopoietic stem cell transplantation (allo-HSCT) allows for precise evaluation and adjustment of radiation dosage. We conducted a single-center pilot study to evaluate the safety of IMRT-TBI for allo-HSCT recipients. Patients with hematological malignancies in remission who were scheduled for allo-HSCT with TBI-based myeloablative conditioning were eligible. The primary endpoint was the incidence of adverse events (AEs). Secondary endpoints were engraftment rate, overall survival, relapse rate, non-relapse mortality, and the incidence of acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively). Between July 2018 and November 2018, ten patients were recruited with a median observation duration of 571 days after allo-HSCT (range, 496–614). D80% for planning target volume (PTV) in all patients was 12.01 Gy. Average D80% values for lungs, kidneys and lenses (right/left) were 7.50, 9.03 and 4.41/4.03 Gy, respectively. Any early AEs (within 100 days of allo-HSCT) were reported in all patients. Eight patients experienced oral mucositis and gastrointestinal symptoms. One patient experienced Bearman criteria grade 3 regimen-related toxicity (kidney and liver). All cases achieved neutrophil engraftment. There was no grade III–IV aGVHD or late AE. One patient died of sinusoidal obstruction syndrome 67 days after allo-HSCT. The remaining nine patients were alive and disease-free at final follow-up. Thus, IMRT-TBI was well tolerated in terms of early AEs in adult patients who underwent allo-HSCT; this warrants further study with longer observation times to monitor late AEs and efficacy.

SU-E-T-813: Using Intensity Modulated Radiation Therapy for Total Body Irradiation - a Phantom Study

2011 ◽  
Vol 38 (6Part23) ◽  
pp. 3678-3678 ◽  
Author(s):  
D Vade BonCoeur ◽  
C Pelloski ◽  
N Gupta ◽  
M Weldon ◽  
J Woollard ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Total Body Irradiation ◽  
Intensity Modulated Radiation Therapy ◽  
Phantom Study ◽  
Intensity Modulated ◽  
Total Body
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