scholarly journals Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand

2004 ◽  
Vol 10 (3) ◽  
pp. 156-170 ◽  
Author(s):  
Yuji Miura ◽  
Christopher J. Thoburn ◽  
Emilie C. Bright ◽  
Allan D. Hess
Keyword(s):  
Gene Expression ◽  
Graft Versus Host Disease ◽  
Fas Ligand ◽  
Host Disease ◽  
Graft Versus Host ◽  
Autologous Graft ◽  
Effector Mechanisms

Eruption of lymphocyte recovery or autologous graft-versus-host disease?

2008 ◽  
Vol 47 ◽  
pp. 32-34 ◽  
Author(s):  
Ruud G. L. Nellen ◽  
Arienne M. W. van Marion ◽  
Jorge Frank ◽  
Pamela Poblete-Gutiérrez ◽  
Peter M. Steijlen
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Autologous Graft

Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

Blood ◽  
1998 ◽  
Vol 91 (11) ◽  
pp. 4051-4055 ◽  
Author(s):  
Koichi Hattori ◽  
Takao Hirano ◽  
Hiroaki Miyajima ◽  
Norifumi Yamakawa ◽  
Masatoshi Tateno ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Graft Versus Host Disease ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Fas Ligand ◽  
Complete Protection ◽  
Host Disease ◽  
Graft Versus Host ◽  
Factor Α ◽  
Necrosis Factor

Abstract Both tumor necrosis factor α (TNFα) and Fas ligand (FasL) have been implicated in the pathogenesis of graft-versus-host disease (GVHD). In this study, we examined the ameliorating effects of neutralizing anti-FasL and/or anti-TNFα monoclonal antibody (MoAb) in a lethal acute GVHD model in mice. Whereas the treatment with either anti-FasL or anti-TNFα MoAb alone significantly delayed the mortality and improved the body weight, a complete protection was achieved by the administration of both MoAbs. Pathological examination indicated differential effects of anti-FasL or anti-TNFα MoAb on GVHD-associated pathologies. Hepatic lesion was improved by anti-FasL but not anti-TNFα MoAb. In contrast, intestinal lesion was improved by anti-TNFα but not anti-FasL MoAb. Cutaneous and splenic lesions were improved by either MoAb. The combination of both MoAbs improved all these lesions. These results indicate that FasL and TNFα differentially contribute to the GVHD pathologies and a complete protection from mortality can be achieved by neutralization of both FasL and TNFα.

scholarly journals Complexity of effector mechanisms in cyclosporine-induced syngeneic graft-versus-host disease

2000 ◽  
Vol 6 (1) ◽  
pp. 13-24 ◽  
Author(s):  
Allan D. Hess ◽  
Christopher J. Thoburn ◽  
Weiran Chen ◽  
Louis R. Horwitz
Keyword(s):  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Effector Mechanisms

Early Detection of Apoptosis and Fas Ligand Expression in Hepatic Graft-versus-Host Disease after Rat Small Bowel Transplantation

1999 ◽  
Vol 86 (1) ◽  
pp. 136-144 ◽  
Author(s):  
Masayuki Shiraishi ◽  
Shungo Hiroyasu ◽  
Takashi Oshiro ◽  
Masayoshi Nagahama ◽  
Hirofumi Tomori ◽  
...  
Keyword(s):  
Small Bowel ◽  
Early Detection ◽  
Graft Versus Host Disease ◽  
Fas Ligand ◽  
Small Bowel Transplantation ◽  
Host Disease ◽  
Graft Versus Host ◽  
Ligand Expression

The relationship between HIF family gene expression in allogeneic T-cell products and acute graft-versus-host disease.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. 7026-7026
Author(s):  
Joseph Rimando ◽  
Steven Larrick ◽  
Nicholas Fowler ◽  
Luciano Castiello ◽  
Syed Abbas Ali ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Family Gene ◽  
The Relationship ◽  
Acute Graft

Regulation of OX40 gene expression in graft-versus-host disease

2005 ◽  
Vol 37 (1) ◽  
pp. 57-61 ◽  
Author(s):  
Y. Miura ◽  
C.J. Thoburn ◽  
E.C. Bright ◽  
S. Arai ◽  
A.D. Hess
Keyword(s):  
Gene Expression ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host

EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENS

1990 ◽  
Vol 50 (1) ◽  
pp. 67-71 ◽  
Author(s):  
CECILE A.C.M. VAN ELS ◽  
ASTRID BARKER ◽  
AEILKO H. ZWINDERMAN ◽  
FERRY E. ZWAAN ◽  
JON J. VAN ROOD ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Histocompatibility Antigens ◽  
Host Disease ◽  
Minor Histocompatibility Antigens ◽  
Graft Versus Host ◽  
Effector Mechanisms

scholarly journals A Metalloproteinase Inhibitor Prevents Lethal Acute Graft-Versus-Host Disease in Mice

Blood ◽  
1997 ◽  
Vol 90 (2) ◽  
pp. 542-548 ◽  
Author(s):  
Koichi Hattori ◽  
Takao Hirano ◽  
Chifuyu Ushiyama ◽  
Hiroaki Miyajima ◽  
Norifumi Yamakawa ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Fas Ligand ◽  
Allogeneic Bone Marrow Transplantation ◽  
Major Complication ◽  
Allogeneic Bone ◽  
Host Disease ◽  
Graft Versus Host ◽  
Metalloproteinase Inhibitor ◽  
Tnf Α ◽  
Necrosis Factor

Tumor necrosis factor (TNF ) and Fas ligand (FasL) have been implicated in the pathogenesis of graft-versus-host disease (GVHD), which is a major complication after allogeneic bone marrow transplantation. We examined here the ameliorating effect of a metalloproteinase inhibitor (KB-R7785) that inhibits TNF-α and FasL release in a lethal acute GVHD model in mice. Administration of KB-R7785 into (BALB/c × C57BL/6) F1 that received C57BL/6 spleen cells markedly reduced the mortality and weight loss in association with minimal signs of GVHD pathology in the liver, intestine, and hematopoietic tissues. The ameliorating effect of KB-R7785 was superior to that of anti–TNF-α antibody. Our results suggest that KB-R7785 could be a potent therapeutic agent for GVHD.

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