Implications of the lysophosphatidic acid signaling axis in liver cancer

2017 ◽  
Vol 1868 (1) ◽  
pp. 277-282 ◽  
Author(s):  
Chiara Lopane ◽  
Pasquale Agosti ◽  
Isabella Gigante ◽  
Carlo Sabbà ◽  
Antonio Mazzocca
Keyword(s):  
Liver Cancer ◽  
Lysophosphatidic Acid ◽  
Signaling Axis ◽  
Lysophosphatidic Acid Signaling

scholarly journals Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts

2018 ◽  
Vol 19 (1) ◽  
pp. 139 ◽  
Author(s):  
Caterina Bernacchioni ◽  
Francesca Cencetti ◽  
Alberto Ouro ◽  
Marina Bruno ◽  
Antonio Gomez-Muñoz ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
C2c12 Myoblasts ◽  
Signaling Axis ◽  
Ceramide 1 ◽  
Lysophosphatidic Acid Signaling

scholarly journals MicroRNA Regulation of the Autotaxin-Lysophosphatidic Acid Signaling Axis

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1369 ◽  
Author(s):  
Mandi M. Murph
Keyword(s):  
Lysophosphatidic Acid ◽  
Current Status ◽  
Mirna Regulation ◽  
Exciting Field ◽  
Microrna Regulation ◽  
Normal Tissues ◽  
Argonaute Proteins ◽  
Signaling Axis ◽  
Lysophosphatidic Acid Signaling ◽  
Lysophosphatidic Acid Receptors

The revelation that microRNAs (miRNAs) exist within the human genome uncovered an underappreciated mechanism of gene expression. For cells to regulate expression of their genes, miRNA molecules and argonaute proteins bind to mRNAs and interfere with efficient translation of the RNA transcript. Although miRNAs have important roles in normal tissues, miRNAs may adopt aberrant functions in malignant cells depending on their classification as either a tumor suppressor or oncogenic miRNA. Within this review, the current status of miRNA regulation is described in the context of signaling through the lysophosphatidic acid receptors, including the lysophosphatidic acid-producing enzyme, autotaxin. Thus far, research has revealed miRNAs that increase in response to lysophosphatidic acid stimulation, such as miR-21, miR-30c-2-3p, and miR-122. Other miRNAs inhibit the translation of lysophosphatidic acid receptors, such as miR-15b, miR-23a, and miR200c, or proteins that are downstream of lysophosphatidic acid signaling, such as miR-146 and miR-21. With thousands of miRNAs still uncharacterized, it is anticipated that the complex regulation of lysophosphatidic acid signaling by miRNAs will continue to be elucidated. RNA-based therapeutics have entered the clinic with enormous potential in precision medicine. This exciting field is rapidly emerging and it will be fascinating to witness its expansion in scope.

scholarly journals Atractylenolide III predisposes miR‐195‐5p/FGFR1 signaling axis to exert tumor‐suppressive functions in liver cancer

2021 ◽  
Author(s):  
Langqing Sheng ◽  
Jiarong Li ◽  
Nianfeng Li ◽  
Liansheng Gong ◽  
Ling Liu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Signaling Axis ◽  
Atractylenolide Iii

scholarly journals Blockage of Lysophosphatidic Acid Signaling Improves Spinal Cord Injury Outcomes

2012 ◽  
Vol 181 (3) ◽  
pp. 978-992 ◽  
Author(s):  
Yona Goldshmit ◽  
Rosalia Matteo ◽  
Tamar Sztal ◽  
Felix Ellett ◽  
Frisca Frisca ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Lysophosphatidic Acid ◽  
Cord Injury ◽  
Injury Outcomes ◽  
Lysophosphatidic Acid Signaling

Book Review: Neurobiology of Lysophosphatidic Acid Signaling

2002 ◽  
Vol 8 (6) ◽  
pp. 540-550 ◽  
Author(s):  
Nobuyuki Fukushima ◽  
Xiaoqin Ye ◽  
Jerold Chun
Keyword(s):  
Lysophosphatidic Acid ◽  
Lysophosphatidic Acid Signaling

scholarly journals Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

2011 ◽  
Vol 3 (99) ◽  
pp. 99ra87-99ra87 ◽  
Author(s):  
Y. C. Yung ◽  
T. Mutoh ◽  
M.-E. Lin ◽  
K. Noguchi ◽  
R. R. Rivera ◽  
...  
Keyword(s):  
Lysophosphatidic Acid ◽  
Fetal Hydrocephalus ◽  
Lysophosphatidic Acid Signaling
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