scholarly journals Tryptophan tryptophylquinone biosynthesis: A radical approach to posttranslational modification

2012 ◽  
Vol 1824 (11) ◽  
pp. 1299-1305 ◽  
Author(s):  
Victor L. Davidson ◽  
Aimin Liu
Keyword(s):  
Posttranslational Modification ◽  
Tryptophan Tryptophylquinone ◽  
Radical Approach

Neurofilaments and Paired Helical Filaments

1985 ◽  
Vol 43 ◽  
pp. 740-743
Author(s):  
J. Metuzals
Keyword(s):  
Animal Model ◽  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Giant Axon ◽  
Paired Helical Filaments ◽  
Squid Giant Axon ◽  
In Vitro Experiments ◽  
Thin Sections ◽  
Structural Relationships

It has been demonstrated that the neurofibrillary tangles in biopsies of Alzheimer patients, composed of typical paired helical filaments (PHF), consist also of typical neurofilaments (NF) and 15nm wide filaments. Close structural relationships, and even continuity between NF and PHF, have been observed. In this paper, such relationships are investigated from the standpoint that the PHF are formed through posttranslational modifications of NF. To investigate the validity of the posttranslational modification hypothesis of PHF formation, we have identified in thin sections from frontal lobe biopsies of Alzheimer patients all existing conformations of NF and PHF and ordered these conformations in a hypothetical sequence. However, only experiments with animal model preparations will prove or disprove the validity of the interpretations of static structural observations made on patients. For this purpose, the results of in vitro experiments with the squid giant axon preparations are compared with those obtained from human patients. This approach is essential in discovering etiological factors of Alzheimer's disease and its early diagnosis.

Molecular pathways of Interferon–Stimulated Gene 15: Implications in cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Angeles C. Tecalco–Cruz
Keyword(s):  
Posttranslational Modification ◽  
Human Interferon ◽  
Molecular Pathways ◽  
Biological Processes ◽  
Small Protein ◽  
Target Proteins ◽  
Central Elements ◽  
Cancer Types ◽  
Interferon Stimulated Gene 15

Abstract:: Human interferon–stimulated gene 15 (ISG15) is a 15–kDa ubiquitin–like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokine–like protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.

Theological Ethics through a Multispecies Lens

2019 ◽  
Author(s):  
Celia E. Deane-Drummond
Keyword(s):  
Animal Rights ◽  
Future Orientation ◽  
Individual Responsibility ◽  
Theological Ethics ◽  
Individual Decision ◽  
Community Based ◽  
Moral Agents ◽  
Nature And Culture ◽  
Different Levels ◽  
Radical Approach

There are two driving questions informing this book. The first is where does our moral life come from? The presupposition is that considering morality broadly is inadequate. Instead, different aspects need to be teased apart. It is not sufficient to assume that different virtues are bolted onto a vicious animality, red in tooth and claw. Nature and culture have interlaced histories. By weaving in evolutionary theories and debates on the evolution of compassion, justice, and wisdom, the book shows a richer account of who we are as moral agents. The second driving question concerns our relationships with animals. There is dissatisfaction with animal rights frameworks and an argument instead for a more complex community-based multispecies approach. Hence, rather than extending rights, a more radical approach is a holistic multispecies framework for moral action. This need not weaken individual responsibility. The intention is not to develop a manual of practice, but rather to build towards an alternative philosophically informed approach to theological ethics, including animal ethics. The theological thread weaving through this account is wisdom. Wisdom has many different levels, and in the broadest sense is connected with the flow of life understood in its interconnectedness and sociality. It is profoundly theological and practical. In naming the project the evolution of wisdom a statement is being made about where wisdom may have come from and its future orientation. But justice, compassion, and conscience are not far behind, especially in so far as they are relevant to both individual decision-making and institutions.

Posttranslational Modification of Human Alpha-Synuclein by Nitro-Oleic Acid

2010 ◽  
Vol 49 ◽  
pp. S158 ◽  
Author(s):  
Jose M Souza ◽  
Andrés Trostchansky ◽  
Carlos Batthyany ◽  
Rosario Durán ◽  
Bruce A Freeman ◽  
...  
Keyword(s):  
Oleic Acid ◽  
Posttranslational Modification ◽  
Alpha Synuclein

scholarly journals Hypusination, a Metabolic Posttranslational Modification of eIF5A in Plants during Development and Environmental Stress Responses

Plants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1261
Author(s):  
Péter Pálfi ◽  
László Bakacsy ◽  
Henrietta Kovács ◽  
Ágnes Szepesi
Keyword(s):  
Amino Acid ◽  
Environmental Stress ◽  
Plant Development ◽  
Stress Responses ◽  
Posttranslational Modification ◽  
Proper Function ◽  
Signal Pathways ◽  
Deoxyhypusine Synthase ◽  
Deoxyhypusine Hydroxylase ◽  
Eukaryotic Translation

Hypusination is a unique posttranslational modification of eIF5A, a eukaryotic translation factor. Hypusine is a rare amino acid synthesized in this process and is mediated by two enzymes, deoxyhypusine synthase (DHS) and deoxyhypusine hydroxylase (DOHH). Despite the essential participation of this conserved eIF5A protein in plant development and stress responses, our knowledge of its proper function is limited. In this review, we demonstrate the main findings regarding how eIF5A and hypusination could contribute to plant-specific responses in growth and stress-related processes. Our aim is to briefly discuss the plant-specific details of hypusination and decipher those signal pathways which can be effectively modified by this process. The diverse functions of eIF5A isoforms are also discussed in this review.

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