An expanded adenylate kinase gene family in the protozoan parasite Trypanosoma cruzi

2006 ◽  
Vol 1760 (6) ◽  
pp. 913-921 ◽  
Author(s):  
Leon A. Bouvier ◽  
Mariana R. Miranda ◽  
Gaspar E. Canepa ◽  
Maria Júlia M. Alves ◽  
Claudio A. Pereira
Keyword(s):  
Trypanosoma Cruzi ◽  
Gene Family ◽  
Adenylate Kinase ◽  
Protozoan Parasite ◽  
Kinase Gene

scholarly journals Intracellular Positioning of Isoforms Explains an Unusually Large Adenylate Kinase Gene Family in the Parasite Trypanosoma brucei

2005 ◽  
Vol 280 (12) ◽  
pp. 11781-11789 ◽  
Author(s):  
Michael L. Ginger ◽  
E. Solange Ngazoa ◽  
Claudio A. Pereira ◽  
Timothy J. Pullen ◽  
Mostafa Kabiri ◽  
...  
Keyword(s):  
Gene Family ◽  
Trypanosoma Brucei ◽  
Adenylate Kinase ◽  
Kinase Gene

scholarly journals The major 85-kD surface antigen of the mammalian form of Trypanosoma cruzi is encoded by a large heterogeneous family of simultaneously expressed genes.

1990 ◽  
Vol 172 (2) ◽  
pp. 589-597 ◽  
Author(s):  
S Kahn ◽  
W C Van Voorhis ◽  
H Eisen
Keyword(s):  
Trypanosoma Cruzi ◽  
Gene Family ◽  
Protozoan Parasite ◽  
Surface Antigens ◽  
African Trypanosomes ◽  
Antigenic Diversity ◽  
Obligate Intracellular ◽  
The Family ◽  
Large Repertoire ◽  
Intracellular Protozoan Parasite

Trypanosoma cruzi is an obligate intracellular protozoan parasite. The parasite mammalian stage surface antigens exhibit extensive antigenic diversity. We have characterized a family of T. cruzi genes that code for a polymorphic set of 85-kD surface antigens, the SA85-1 antigens. The family contains greater than 100 genes and pseudogenes, of which a minimum of nine are transcribed. The gene family is expressed in the mammalian stage only. A subset of the gene family is present in two telomere-linked copies in the genome. Telomere linkage of other expressed SA85-1 genes has not been demonstrated. We have shown that at least three members of the SA85-1 gene family encode antigens at the surface of the mammalian stage of the parasite. Interestingly, these three antigens are expressed on all the trypanosomes examined. This suggests that T. cruzi simultaneously expresses a large repertoire of similar, but diverse antigens at its surface. Thus, T. cruzi exhibits extensive antigenic diversity in a system unique from that of African trypanosomes, perhaps reflecting its intracellular niche.

Trypanosoma cruzi: Genome characterization of phosphatidylinositol kinase gene family (PIK and PIK-related) and identification of a novel PIK gene

2014 ◽  
Vol 25 ◽  
pp. 157-165 ◽  
Author(s):  
Priscila Oliveira ◽  
Fabio Mitsuo Lima ◽  
Mario Costa Cruz ◽  
Renata Carmona Ferreira ◽  
Alejandro Sanchez-Flores ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Gene Family ◽  
Kinase Gene ◽  
Genome Characterization ◽  
Phosphatidylinositol Kinase

scholarly journals The Evolutionary History and Diverse Physiological Roles of the Grapevine Calcium-Dependent Protein Kinase Gene Family

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e80818 ◽  
Author(s):  
Fei Chen ◽  
Marianna Fasoli ◽  
Giovanni Battista Tornielli ◽  
Silvia Dal Santo ◽  
Mario Pezzotti ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Gene Family ◽  
Evolutionary History ◽  
Dependent Protein Kinase ◽  
Kinase Gene ◽  
Calcium Dependent ◽  
Dependent Protein ◽  
Protein Kinase Gene ◽  
Calcium Dependent Protein Kinase

Temperature, Mitochondria, and Reye's Syndrome

PEDIATRICS ◽  
1983 ◽  
Vol 71 (6) ◽  
pp. 985-985
Author(s):  
RIF S. EL-MALLAKH
Keyword(s):  
Trypanosoma Cruzi ◽  
Chagas Disease ◽  
Protozoan Parasite ◽  
Mitochondrial Enzyme ◽  
Reye's Syndrome ◽  
Electron Microscopic ◽  
Microscopic Studies ◽  
Mitochondrial Defect ◽  
Intracellular Protozoan Parasite

To the Editor.— Mitochondrial failure, manifest by changes in mitochondrial enzyme activity1-3 and morphology,4-5 is central to Reye's syndrome (RS).6 Although it has been variously hypothesized that the mitochondrial changes are secondary to an exogenous toxin,7-12 or an intrinsic mitochondrial defect,6 the actual cause remains obscure. Electron microscopic studies have shown sweelling and loss of cristate in mitochondria of patients with RS. It is interesting that very similar changes occur in Trypanosoma cruzi.13-16 T cruzi is an extracellular/intracellular protozoan parasite which causes Chagas' disease.17

scholarly journals In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi

2004 ◽  
Vol 99 (2) ◽  
pp. 233-235 ◽  
Author(s):  
Patricia B Petray ◽  
María J Morilla ◽  
Ricardo S Corral ◽  
Eder L Romero
Keyword(s):  
Trypanosoma Cruzi ◽  
Protozoan Parasite ◽  
Vitro Activity ◽  
In Vitro Activity

Mapping of tyrosine kinase gene family members in aXiphophorus melanoma model

1998 ◽  
Vol 22 (3) ◽  
pp. 150-157 ◽  
Author(s):  
Donald C. Morizot ◽  
Brenda B. McEntire ◽  
Luis Della Coletta ◽  
Steven Kazianis ◽  
Manfred Schartl ◽  
...  
Keyword(s):  
Tyrosine Kinase ◽  
Gene Family ◽  
Family Members ◽  
Kinase Gene ◽  
Melanoma Model ◽  
Tyrosine Kinase Gene
Sign in / Sign up

Export Citation Format

Share Document