Dopaminergic modulation of neural correlates of working memory in Parkinson’s Disease

Basal Ganglia ◽  
2012 ◽  
Vol 2 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Eduard Kraft ◽  
Ellen Binder ◽  
Dorothee Lulé ◽  
Alexander Storch ◽  
Oliver Gruber
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Neural Correlates ◽  
Dopaminergic Modulation

scholarly journals The Neural Correlates of Spatial and Object Working Memory in Elderly and Parkinson’s Disease Subjects

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Silvia P. Caminiti ◽  
Chiara Siri ◽  
Lucia Guidi ◽  
Angelo Antonini ◽  
Daniela Perani
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Neural Correlates ◽  
Elderly Subjects ◽  
Task Execution ◽  
Compensatory Mechanisms ◽  
Frontoparietal Network ◽  
Fmri Study ◽  
Comparable Performance

This fMRI study deals with the neural correlates of spatial and objects working memory (SWM and OWM) in elderly subjects (ESs) and idiopathic Parkinson’s disease (IPD). Normal aging and IPD can be associated with a WM decline. In IPD population, some studies reported similar SWM and OWM deficits; others reported a greater SWM than OWM impairment. In the present fMRI research, we investigated whether compensated IPD patients and elderly subjects with comparable performance during the execution of SWM and OWM tasks would present differences in WM-related brain activations. We found that the two groups recruited a prevalent left frontoparietal network when performing the SWM task and a bilateral network during OWM task execution. More specifically, the ESs showed bilateral frontal and subcortical activations in SWM, at difference with the IPD patients who showed a strict left lateralized network, consistent with frontostriatal degeneration in IPD. The overall brain activation in the IPD group was more extended as number of voxels with respect to ESs, suggesting underlying compensatory mechanisms. In conclusion, notwithstanding comparable WM performance, the two groups showed consistencies and differences in the WM activated networks. The latter underline the compensatory processes of normal typical and pathological aging.

Dopaminergic Modulation of Visual-Spatial Working Memory in Parkinson’s Disease

2003 ◽  
Vol 15 (2) ◽  
pp. 55-66 ◽  
Author(s):  
Alberto Costa ◽  
Antonella Peppe ◽  
Grazia Dell’Agnello ◽  
Giovanni Augusto Carlesimo ◽  
Luigi Murri ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Spatial Working Memory ◽  
Visual Spatial ◽  
Dopaminergic Modulation ◽  
Visual Spatial Working Memory

scholarly journals Working memory training increases neural efficiency in Parkinson’s disease: a randomized controlled trial

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Kathrin Giehl ◽  
Anja Ophey ◽  
Jochen Hammes ◽  
Sarah Rehberg ◽  
Thorsten Lichtenstein ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Functional Connectivity ◽  
Controlled Trial ◽  
Memory Task ◽  
Neural Correlates ◽  
Working Memory Training ◽  
Memory Training ◽  
Memory Processes

Abstract Impairment of working memory and executive functions is already frequently observed in early stages of Parkinson’s disease. Improvements in working memory performance in this cohort could potentially be achieved via working memory training. However, the specific neural mechanisms underlying different working memory processes such as maintenance as opposed to manipulation are largely under-investigated in Parkinson’s disease. Moreover, the plasticity of these correlates as a function of working memory training is currently unknown in this population. Thus, the working memory subprocesses of maintenance and manipulation were assessed in 41 cognitively healthy patients with Parkinson’s disease using a newly developed working memory paradigm and functional MRI. Nineteen patients were randomized to a 5-week home-based digital working memory training intervention while the remaining patients entered a control, wait list condition. Working memory task-related activation patterns and context-dependent functional connectivity, as well as the change of these neural correlates as a function of training, were assessed. While both working memory processes activated an extended frontoparietal–cerebellar network, only the manipulation of items within working memory also recruited the anterior striatum. The intervention effect on the neural correlates was small, but decreased activation in areas relevant for working memory could be observed, with activation changes correlating with behavioural change. Moreover, training seemed to result in decreased functional connectivity when pure maintenance was required, and in a reorganization of functional connectivity when items had to be manipulated. In accordance with the neural efficacy hypothesis, training resulted in overall reduced activation and reorganized functional connectivity, with a differential effect on the different working memory processes under investigation. Now, larger trials including follow-up examinations are needed to further explore the long-term effects of such interventions on a neural level and to estimate the clinical relevance to potentially delay cognitive decline in cognitively healthy patients with Parkinson’s disease.

Hypophonia in Parkinson's disease: Neural correlates of voice treatment revealed by PET

Neurology ◽  
2003 ◽  
Vol 60 (3) ◽  
pp. 432-440 ◽  
Author(s):  
M. Liotti ◽  
L.O. Ramig ◽  
D. Vogel ◽  
P. New ◽  
C.I. Cook ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Correlates ◽  
Voice Treatment

Dopaminergic modulation of emotional memory in Parkinson’s disease

2008 ◽  
Vol 115 (8) ◽  
pp. 1159-1163 ◽  
Author(s):  
Thomas D. Hälbig ◽  
Ute A. Kopp ◽  
Franziska Wodarz ◽  
Joan C. Borod ◽  
Jean-Michel Gracies ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Emotional Memory ◽  
Dopaminergic Modulation

Dopaminergic modulation of reward-based learning in Parkinson's disease

2010 ◽  
Vol 77 (3) ◽  
pp. 265-265 ◽  
Author(s):  
N.C. van Wouwe ◽  
S.A. Wylie ◽  
G.P.H. Band ◽  
W.P.M. van den Wildenberg ◽  
K.R. Ridderinkhof
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Dopaminergic Modulation

The effects of clinical motor variables and medication dosage on working memory in Parkinson’s disease

2013 ◽  
Vol 82 (2) ◽  
pp. 137-145 ◽  
Author(s):  
Ahmed A. Moustafa ◽  
Peter Bell ◽  
Abeer M. Eissa ◽  
Doaa H. Hewedi
Keyword(s):  
Parkinson’S Disease ◽  
Working Memory ◽  
Parkinson's Disease ◽  
Medication Dosage

scholarly journals Dopaminergic Modulation of Sensory Attenuation in Parkinson's Disease: Is There an Underlying Modulation of Beta Power?

2019 ◽  
Vol 10 ◽  
Author(s):  
Antonella Macerollo ◽  
Patricia Limousin ◽  
Prasad Korlipara ◽  
Tom Foltynie ◽  
Mark J. Edwards ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Beta Power ◽  
Dopaminergic Modulation ◽  
Sensory Attenuation

scholarly journals Neural Correlates of Freezing of Gait in Parkinson's Disease: An Electrophysiology Mini-Review

2020 ◽  
Vol 11 ◽  
Author(s):  
J. Sebastian Marquez ◽  
S. M. Shafiul Hasan ◽  
Masudur R. Siddiquee ◽  
Corneliu C. Luca ◽  
Virendra R. Mishra ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Freezing Of Gait ◽  
Neural Correlates

scholarly journals Identifying the neural correlates of doorway freezing in Parkinson's disease

2019 ◽  
Vol 40 (7) ◽  
pp. 2055-2064 ◽  
Author(s):  
Elie Matar ◽  
James M. Shine ◽  
Moran Gilat ◽  
Kaylena A. Ehgoetz Martens ◽  
Philip B. Ward ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Neural Correlates
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