scholarly journals Identifying the neural correlates of doorway freezing in Parkinson's disease

2019 ◽  
Vol 40 (7) ◽  
pp. 2055-2064 ◽  
Author(s):  
Elie Matar ◽  
James M. Shine ◽  
Moran Gilat ◽  
Kaylena A. Ehgoetz Martens ◽  
Philip B. Ward ◽  
...  
Neurology ◽  
2003 ◽  
Vol 60 (3) ◽  
pp. 432-440 ◽  
Author(s):  
M. Liotti ◽  
L.O. Ramig ◽  
D. Vogel ◽  
P. New ◽  
C.I. Cook ◽  
...  

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Silvia P. Caminiti ◽  
Chiara Siri ◽  
Lucia Guidi ◽  
Angelo Antonini ◽  
Daniela Perani

This fMRI study deals with the neural correlates of spatial and objects working memory (SWM and OWM) in elderly subjects (ESs) and idiopathic Parkinson’s disease (IPD). Normal aging and IPD can be associated with a WM decline. In IPD population, some studies reported similar SWM and OWM deficits; others reported a greater SWM than OWM impairment. In the present fMRI research, we investigated whether compensated IPD patients and elderly subjects with comparable performance during the execution of SWM and OWM tasks would present differences in WM-related brain activations. We found that the two groups recruited a prevalent left frontoparietal network when performing the SWM task and a bilateral network during OWM task execution. More specifically, the ESs showed bilateral frontal and subcortical activations in SWM, at difference with the IPD patients who showed a strict left lateralized network, consistent with frontostriatal degeneration in IPD. The overall brain activation in the IPD group was more extended as number of voxels with respect to ESs, suggesting underlying compensatory mechanisms. In conclusion, notwithstanding comparable WM performance, the two groups showed consistencies and differences in the WM activated networks. The latter underline the compensatory processes of normal typical and pathological aging.


2020 ◽  
Vol 11 ◽  
Author(s):  
J. Sebastian Marquez ◽  
S. M. Shafiul Hasan ◽  
Masudur R. Siddiquee ◽  
Corneliu C. Luca ◽  
Virendra R. Mishra ◽  
...  

US Neurology ◽  
2009 ◽  
Vol 05 (01) ◽  
pp. 30 ◽  
Author(s):  
Tao Wu ◽  
Mark Hallett ◽  
◽  

Performing two tasks simultaneously (dual task performance) is a frequent activity in human life. Patients with Parkinson’s disease (PD) commonly have more difficulty in performing dual tasks than healthy people. To date, research on the mechanisms of dual task interference in PD remains sparse. A recent study by Wu and Hallett in 2008 investigated the central neural correlates of dual task interference in PD, and demonstrated that dual task interference in PD is due to multiple reasons. First, the limitation of capacity of attentional resources is exceeded; second, PD patients perform tasks less automatically compared with normal subjects; and third, the central executive may be defective. However, our knowledge of this phenomenon is still far from complete and needs further investigation.


2014 ◽  
Vol 220 (3) ◽  
pp. 1637-1648 ◽  
Author(s):  
Claudia Diana Wurster ◽  
Heiko Graf ◽  
Hermann Ackermann ◽  
Katharina Groth ◽  
Jan Kassubek ◽  
...  

2005 ◽  
Vol 32 (S 4) ◽  
Author(s):  
C Lie ◽  
M Dafotakis ◽  
S Behrens ◽  
G.R Fink

2019 ◽  
Vol 399 ◽  
pp. 22-29 ◽  
Author(s):  
Ece Bayram ◽  
Brent Bluett ◽  
Xiaowei Zhuang ◽  
Dietmar Cordes ◽  
Denise R. LaBelle ◽  
...  

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