Reduced Krüppel-like Factor 17 (KLF17) Expression Correlates with Poor Survival in Patients with Gastric Cancer

2014 ◽  
Vol 45 (5) ◽  
pp. 394-399 ◽  
Author(s):  
Jing-jing Peng ◽  
Biao Wu ◽  
Xin-bo Xiao ◽  
Yong-sheng Shao ◽  
Yan Feng ◽  
...  
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2018 ◽  
Vol 214 (10) ◽  
pp. 1539-1543 ◽  
Author(s):  
Chun-Li Chen ◽  
Qing Ke ◽  
Ming Luo ◽  
Zi-Ye Gao ◽  
Zhi-Jiu Li ◽  
...  
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2004 ◽  
Vol 6 (3) ◽  
pp. 243-252 ◽  
Author(s):  
Amy J. French ◽  
Gina Petroni ◽  
Stephen N. Thibideau ◽  
Mark Smolkin ◽  
Eric Bissonette ◽  
...  

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Lulu Zhao ◽  
Huang Huang ◽  
Dongbin Zhao ◽  
Chengfeng Wang ◽  
Yantao Tian ◽  
...  

Background. The prognostic relevance of gastric tumor location has been reported and debated. Our study was conducted to examine the differences in clinicopathological features, prognostic factors, and overall survival (OS) between patients with proximal gastric cancer (PGC) and distal gastric cancer (DGC). Patients and Methods. Patients with PGC or DGC were identified from the China National Cancer Center Gastric Cancer Database (NCCGCDB) during 1997–2017. Survival analysis was performed via Kaplan-Meier estimates and Cox proportional hazards models. Results. We reviewed 16,119 cases of gastric cancer patients, including 6,479 of PGC and 9,640 of DGC. PGC patients presented as older patients (61.5 versus 56.4 years, P<0.001) and more males (82.9% versus 68.2%, P<0.001). Compared with DGC, PGC was more likely to be in later pT stage (pT3 and pT4, 65.0% versus 52.8%, P<0.001) and lymph node metastasis (54.8% versus 50.9%, P<0.001). In univariate analysis, PGC patients had a worse survival outcome in stage I (Hazard ratio [HR] = 2.04, 95% CI: 1.42-2.94) but a better prognosis in stage IV (HR = 0.85, 95% CI: 0.73-0.98) when compared to DGC patients. However, multivariate analysis demonstrated that PGC was not an independent predictor for poor survival (HR = 1.07, 95% CI: 1.00-1.14). Results from multivariate analysis also revealed that pT4, lymph node metastasis, distant metastasis, no gastrectomy, and Borrmann IV were independent predictors associated with poor survival for both PGC and DGC patients. Additional prognostic factors for PGC patients included underweight (BMI < 18.5) (HR = 1.29, 95% CI: 1.06-1.58), linitis plastica (HR = 2.13, 95% CI: 1.25-3.65), and overweight (23 ≤ BMI <27.5) (HR = 0.80, 95% CI: 0.71-0.90). During the 20-year study period, the 5-year OS increased significantly for both PGC and DGC, with the increase rate of 91.7% and 67.7%, respectively. Conclusion. In China, PGC significantly differed from DGC in clinicopathological characteristics and prognostic factors. However, there was no significant relationship between survival outcome and gastric tumor location.


2018 ◽  
Vol Volume 11 ◽  
pp. 25-36 ◽  
Author(s):  
Teming Zhang ◽  
Zheng Han ◽  
Arvine Chandoo ◽  
Xincheng Huang ◽  
Xiangwei Sun ◽  
...  

2015 ◽  
Vol 35 (3) ◽  
pp. 1727-1731 ◽  
Author(s):  
NAOMI HAYASHI ◽  
YUICHI ANDO ◽  
BISHAL GYAWALI ◽  
TOMOYA SHIMOKATA ◽  
OSAMU MAEDA ◽  
...  

2017 ◽  
Vol 14 (1) ◽  
pp. 404-410 ◽  
Author(s):  
Tomoki Aburatani ◽  
Mikito Inokuchi ◽  
Yoko Takagi ◽  
Toshiaki Ishikawa ◽  
Keisuke Okuno ◽  
...  

2017 ◽  
Vol 15 (1) ◽  
Author(s):  
Chiharu Tomii ◽  
Mikito Inokuchi ◽  
Yoko Takagi ◽  
Toshiaki Ishikawa ◽  
Sho Otsuki ◽  
...  
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2018 ◽  
Vol 64 (03/2018) ◽  
Author(s):  
Xiaojuan Ouyang ◽  
Yuan Dang ◽  
Fan Zhang ◽  
Qiaojia Huang

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