scholarly journals High expression of P21-activated kinase 5 protein is associated with poor survival in gastric cancer

2017 ◽  
Vol 14 (1) ◽  
pp. 404-410 ◽  
Author(s):  
Tomoki Aburatani ◽  
Mikito Inokuchi ◽  
Yoko Takagi ◽  
Toshiaki Ishikawa ◽  
Keisuke Okuno ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Expression ◽  
Poor Survival ◽  
P21 Activated Kinase

scholarly journals High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Baongoc Nasri ◽  
Mikito Inokuchi ◽  
Toshiaki Ishikawa ◽  
Hiroyuki Uetake ◽  
Yoko Takagi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
High Expression ◽  
Poor Survival

scholarly journals P21-Activated Kinase 4 Overexpression in Metastatic Gastric Cancer Patients

2011 ◽  
Vol 4 (6) ◽  
pp. 345-349 ◽  
Author(s):  
Hee Kyung Ahn ◽  
Jiryeon Jang ◽  
Jeeyun Lee ◽  
Hoon Park Se ◽  
Joon Oh Park ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Patients ◽  
Metastatic Gastric Cancer ◽  
P21 Activated Kinase ◽  
Gastric Cancer Patients

scholarly journals Hypoxia promotes IL-32 expression in myeloma cells, and high expression is associated with poor survival and bone loss

2017 ◽  
Vol 1 (27) ◽  
pp. 2656-2666 ◽  
Author(s):  
Muhammad Zahoor ◽  
Marita Westhrin ◽  
Kristin Roseth Aass ◽  
Siv Helen Moen ◽  
Kristine Misund ◽  
...  
Keyword(s):  
Bone Loss ◽  
Proinflammatory Cytokine ◽  
Plasma Cells ◽  
Bone Destruction ◽  
High Expression ◽  
Poor Survival ◽  
Myeloma Cells ◽  
Key Points

Key Points IL-32 is a proinflammatory cytokine expressed by plasma cells in a subset of MM patients, and high expression correlates with poor survival. IL-32 is induced by hypoxia and secreted from MM cells in EVs that promote bone destruction.

Loss of LINC01939 expression predicts progression and poor survival in gastric cancer

2018 ◽  
Vol 214 (10) ◽  
pp. 1539-1543 ◽  
Author(s):  
Chun-Li Chen ◽  
Qing Ke ◽  
Ming Luo ◽  
Zi-Ye Gao ◽  
Zhi-Jiu Li ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Poor Survival

scholarly journals Allelic Imbalance of 8p Indicates Poor Survival in Gastric Cancer

2004 ◽  
Vol 6 (3) ◽  
pp. 243-252 ◽  
Author(s):  
Amy J. French ◽  
Gina Petroni ◽  
Stephen N. Thibideau ◽  
Mark Smolkin ◽  
Eric Bissonette ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Allelic Imbalance ◽  
Poor Survival

scholarly journals Expression of LOX Suggests Poor Prognosis in Gastric Cancer

2021 ◽  
Vol 8 ◽  
Author(s):  
Jinfeng Zhu ◽  
Chen Luo ◽  
Jiefeng Zhao ◽  
Xiaojian Zhu ◽  
Kang Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Poor Prognosis ◽  
Cox Regression ◽  
Gene Set Enrichment Analysis ◽  
High Expression ◽  
Expression Level ◽  
Cox Regression Analysis

Background: Lysyl oxidase (LOX) is a key enzyme for the cross-linking of collagen and elastin in the extracellular matrix. This study evaluated the prognostic role of LOX in gastric cancer (GC) by analyzing the data of The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO) dataset.Methods: The Wilcoxon rank-sum test was used to calculate the expression difference of LOX gene in gastric cancer and normal tissues. Western blot and immunohistochemical staining were used to evaluate the expression level of LOX protein in gastric cancer. Kaplan-Meier analysis was used to calculate the survival difference between the high expression group and the low expression group in gastric cancer. The relationship between statistical clinicopathological characteristics and LOX gene expression was analyzed by Wilcoxon or Kruskal-Wallis test and logistic regression. Univariate and multivariate Cox regression analysis was used to find independent risk factors affecting the prognosis of GC patients. Gene set enrichment analysis (GSEA) was used to screen the possible mechanisms of LOX and GC. The CIBERSORT calculation method was used to evaluate the distribution of tumor-infiltrating immune cell (TIC) abundance.Results: LOX is highly expressed in gastric cancer tissues and is significantly related to poor overall survival. Wilcoxon or Kruskal-Wallis test and Logistic regression analysis showed, LOX overexpression is significantly correlated with T-stage progression in gastric cancer. Multivariate Cox regression analysis on TCGA and GEO data found that LOX (all p < 0.05) is an independent factor for poor GC prognosis. GSEA showed that high LOX expression is related to ECM receptor interaction, cancer, Hedgehog, TGF-beta, JAK-STAT, MAPK, Wnt, and mTOR signaling pathways. The expression level of LOX affects the immune activity of the tumor microenvironment in gastric cancer.Conclusion: High expression of LOX is a potential molecular indicator for poor prognosis of gastric cancer.

scholarly journals High Expression of GSDMC Is Associated with Poor Survival in Kidney Clear Cell Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Yun-Qian Cui ◽  
Fei Meng ◽  
Wen-Li Zhan ◽  
Zhou-Tong Dai ◽  
Xinghua Liao
Keyword(s):  
Potential Role ◽  
Clear Cell ◽  
Cell Cancer ◽  
Progression Free Survival ◽  
Renal Clear Cell Carcinoma ◽  
High Expression ◽  
Poor Survival ◽  
Free Survival

This study is aimed at exploring the potential role of GSDMC in kidney renal clear cell carcinoma (KIRC). We analyzed the expression of GSDMC in 33 types of cancers in TCGA database. The results showed that the expression of GSDMC was upregulated in most cancers. We found a significant association between high expression of GSDMC and shortened patient overall survival, progression-free survival, and disease-specific survival. In vitro experiments have shown that the expression of GSDMC was significantly elevated in KIRC cell lines. Moreover, decreased expression of GSDMC was significantly associated with decreased cell proliferation. In summary, we believe that this study provides valuable data supporting future clinical treatment.

Sign in / Sign up

Export Citation Format

Share Document