A surface-mediated siRNA delivery system developed with chitosan/hyaluronic acid-siRNA multilayer films through layer-by-layer self-assembly

2016 ◽  
Vol 389 ◽  
pp. 395-403 ◽  
Author(s):  
Lijuan Wu ◽  
Changlin Wu ◽  
Guangwan Liu ◽  
Nannan Liao ◽  
Fang Zhao ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Delivery System ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Sirna Delivery System

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

2014 ◽  
Vol 50 (58) ◽  
pp. 7806-7809 ◽  
Author(s):  
Hangxiang Wang ◽  
Wei Chen ◽  
Haiyang Xie ◽  
Xuyong Wei ◽  
Shengyong Yin ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gene Silencing ◽  
Delivery System ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Single Step ◽  
Chimeric Peptide ◽  
Supramolecular Nanoparticles ◽  
Sirna Delivery System

A practical and tumor cell-specific siRNA delivery system was developedviasingle-step self-assembly of an arginine-rich chimeric peptide with siRNA.

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

2018 ◽  
Vol 24 (16) ◽  
pp. 1788-1800 ◽  
Author(s):  
Kye-Soo Cho ◽  
Seo-Jin Hong ◽  
Min-Hye Ahn ◽  
Sukdeb Pal ◽  
Pill-Hoon Choung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Public Health Issue ◽  
Magic Bullet ◽  
Bodily Fluids ◽  
Low Cytotoxicity ◽  
Genetic And Environmental Factors ◽  
Sirna Delivery System

Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising and novel agents is the siRNA delivery system; however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA. Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for cancer treatment, and 2) a description of the five major cancer-targeting ligands.

scholarly journals Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy

2007 ◽  
Author(s):  
Jiehua Zhou ◽  
Haitang Li ◽  
Shirley Li ◽  
John Zaia ◽  
John Rossi
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Cell Type ◽  
Cell Type Specific ◽  
Hiv 1 ◽  
Sirna Delivery System

Layer-by-layer self-assembly of multilayer films based on humic acid

2011 ◽  
Vol 519 (13) ◽  
pp. 4324-4328 ◽  
Author(s):  
Zhengxia Xu ◽  
Chenyang Hu ◽  
Hu Guoxin
Keyword(s):  
Humic Acid ◽  
Self Assembly ◽  
Multilayer Films ◽  
Layer By Layer

Salivary polypeptide/hyaluronic acid multilayer coatings act as “fungal repellents” and prevent biofilm formation on biomaterials

2018 ◽  
Vol 6 (10) ◽  
pp. 1452-1457 ◽  
Author(s):  
Jianchuan Wen ◽  
Chih-Ko Yeh ◽  
Yuyu Sun
Keyword(s):  
Hyaluronic Acid ◽  
Self Assembly ◽  
Biofilm Formation ◽  
Design Principle ◽  
Multilayer Coatings ◽  
Layer By Layer ◽  
Denture Stomatitis ◽  
Polyelectrolyte Layer ◽  
Assembly Technology ◽  
Systemic Health

Candida-associated denture stomatitis (CADS) is a common, recurring clinical complication in denture wearers that can lead to serious oral and systemic health problems. Polyelectrolyte layer-by-layer (LBL) self-assembly technology on denture materials offers a new design principle for controlling fungal biofilm formation.

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

2019 ◽  
Vol 57 (2) ◽  
pp. 635-649 ◽  
Author(s):  
J. H. Azambuja ◽  
R. S. Schuh ◽  
L. R. Michels ◽  
N. E. Gelsleichter ◽  
L. R. Beckenkamp ◽  
...  
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Nasal Administration ◽  
Sirna Delivery System

scholarly journals Fabrication and in vitro evaluation of stable collagen/hyaluronic acid biomimetic multilayer on titanium coatings

2013 ◽  
Vol 10 (84) ◽  
pp. 20130070 ◽  
Author(s):  
Haiyong Ao ◽  
Youtao Xie ◽  
Honglue Tan ◽  
Shengbing Yang ◽  
Kai Li ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Photoelectron Spectroscopy ◽  
Self Assembly ◽  
Human Mesenchymal Stem Cells ◽  
Biological Properties ◽  
Covalent Immobilization ◽  
Layer By Layer ◽  
Titanium Coating ◽  
Assembly Technique

Layer-by-layer (LBL) self-assembly technique has been proved to be a highly effective method to immobilize the main components of the extracellular matrix such as collagen and hyaluronic acid on titanium-based implants and form a polyelectrolyte multilayer (PEM) film by electrostatic interaction. However, the formed PEM film is unstable in the physiological environment and affects the long-time effectiveness of PEM film. In this study, a modified LBL technology has been developed to fabricate a stable collagen/hyaluronic acid (Col/HA) PEM film on titanium coating (TC) by introducing covalent immobilization. Scanning electron microscopy, diffuse reflectance Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy were used to characterize the PEM film. Results of Sirius red staining demonstrated that the chemical stability of PEM film was greatly improved by covalent cross-linking. Cell culture assays further illustrated that the functions of human mesenchymal stem cells, such as attachment, spreading, proliferation and differentiation, were obviously enhanced by the covalently immobilized Col/HA PEM on TCs compared with the absorbed Col/HA PEM. The improved stability and biological properties of the Col/HA PEM covalently immobilized TC may be beneficial to the early osseointegration of the implants.

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