Interfacing biomembrane mimetic polymer surfaces with living cells – Surface modification for reliable bioartificial liver

2008 ◽  
Vol 255 (2) ◽  
pp. 523-528 ◽  
Author(s):  
Yasuhiko Iwasaki ◽  
Utae Takami ◽  
Shin-ichi Sawada ◽  
Kazunari Akiyoshi
Keyword(s):  
Surface Modification ◽  
Living Cells ◽  
Bioartificial Liver ◽  
Polymer Surfaces

scholarly journals Influence of a Point-to-Plane DC Negative Corona Discharge on Gel Surfaces

10.14311/1033 ◽  
2008 ◽  
Vol 48 (4) ◽  
Author(s):  
Y. Klenko ◽  
V. Scholtz
Keyword(s):  
Experimental Investigation ◽  
Surface Modification ◽  
Electric Field ◽  
Corona Discharge ◽  
Biomedical Applications ◽  
Single Point ◽  
Polymer Surfaces ◽  
Negative Corona ◽  
Negative Corona Discharge ◽  
Time Periods

Point-to-plane corona discharge is widely used for modifying polymer surfaces for biomedical applications and for sterilization and decontamination. This paper focuses on an experimental investigation of the influence of the single-point and multi-point corona discharge electric field on gel surface. Three types of gelatinous agar were used as the gel medium: blood agar, nutrient agar and Endo agar. The gel surface modification was studied for various time periods and discharge currents. 

Lubricin as a Surface Treatment to Reduce Post-operative Biofouling and Infection

2012 ◽  
Vol 1486 ◽  
Author(s):  
George E. Aninwene ◽  
Doug Hall ◽  
Amy Mei ◽  
Gregory D. Jay ◽  
Thomas J. Webster
Keyword(s):  
Surface Modification ◽  
Synovial Fluid ◽  
Bacterial Infection ◽  
Bacterial Adhesion ◽  
Surface Coating ◽  
Polymer Surfaces ◽  
Intraocular Lenses ◽  
Tissue Cultures ◽  
Bacteria Growth ◽  
Adhesive Protein

ABSTRACTThe goal of this research was to investigate the ability of lubricin to prevent bio-fouling of intraocular lenses after surgery, through surface coating trials with lubricin and analogues of the two major sub-units of the lubricin molecule (mucin and vitronectin). Yearly, there are over 6 million surgeries worldwide that involve intraocular lenses (IOLs) 1. However, preventing post-operative biofouling and bacterial infection of these implants remains a challenge 2. Surface modification of IOLs may provide a solution. This study proposes the use of the anti-adhesive protein lubricin (LUB), a glycoprotein found in the synovial fluid, as a means to make polymer surfaces less prone to bacterial adhesion and proliferation; thus, reducing the opportunity for post-operative infection 3. This study used extended bacteria growth trials on tissue cultures polystyrene coated with either lubricin, vitronectin, or mucin to investigate how lubricin and protein sub-regions of lubricin may reduce bacterial adhesion and proliferation.

The Biological Membrane

MRS Bulletin ◽  
1992 ◽  
Vol 17 (11) ◽  
pp. 53-55 ◽  
Author(s):  
Mark Alper
Keyword(s):  
Drug Delivery ◽  
Surface Modification ◽  
Small Molecules ◽  
Drug Delivery Systems ◽  
Biological Membrane ◽  
Electrical Energy ◽  
Living Cells ◽  
Information Storage ◽  
Selective Transport ◽  
Surrounding Environment

All living cells, and many of the structures within these cells (mitochondria, nuclei, chloroplasts) are surrounded by biological membranes which serve to separate the cell contents from the surrounding environment. The biological membrane is an extraordinary material. It controls the highly selective transport of molecules into and out of the cell. It senses the environment outside the cell and transmits information about it to the intracellular machinery. It reports information about the cell to the outside world—its identity and its state of function. It transports electrons, converts sunlight to chemical and electrical energy, pumps small molecules against a concentration gradient, and uses that gradient as a source of energy. The membrane is a generally robust structure, and one that can be modified in a controlled manner, making it adaptable for use in nonbiological applications. It has served as a model for sensors and detectors, for surface modification agents, for drug delivery systems, and for information storage and delivery, as well as other optoelectronic functions.

Living Cells: Surface Modification

2015 ◽  
pp. 4378-4387
Author(s):  
Yuji Teramura ◽  
Hao Chen ◽  
Naohiro Takemoto ◽  
Kengo Sakurai ◽  
Hiroo Iwata
Keyword(s):  
Surface Modification ◽  
Living Cells

Plasma-Enhanced Surface Modification of Biopolymers

2005 ◽  
Author(s):  
K. Komvopoulos
Keyword(s):  
Surface Modification ◽  
Effective Means ◽  
Polymer Surface ◽  
Chemical Properties ◽  
Biochemical Properties ◽  
Polymer Surfaces ◽  
Polymer Materials ◽  
Rf Plasma ◽  
Main Process ◽  
Enhanced Surface

Recent advances in polymer surface science have been largely due to the well-recognized need to control the surface properties of polymer materials and the development of sophisticated surface-specific characterization techniques. While the majority of the research and development efforts have been mostly focused on bulk properties, demands for low surface energy polymers exhibiting low adhesion (friction) and good biocompatibility have generated significant interest on physical and chemical properties of polymer surfaces. For instance, ultra-high molecular weight polyethylene (UHMWPE) and low-density polyethylene (LDPE) are the principal materials used to replace damaged cartilage in total joint arthroplasty and to fabricate catheters for balloon angioplasty, respectively. Therefore, surface treatments to improve adhesion and biocompatibility of these polymer surfaces are of paramount importance in the medical field. Radio frequency (rf) plasma-enhanced surface modification (PESM) provides an effective means for altering the biochemical properties of polymer surfaces without affecting the bulk behavior. The main process steps of PESM are discussed here and its effectiveness is demonstrated by representative friction coefficient, contact angle, and biocompatibility results for LDPE and UHMWPE surfaces treated with various plasma chemistries.

Surface Modification of Si3N4-Coated Silicon Plate for Investigation of Living Cells

2000 ◽  
Vol 39 (Part 1, No. 11) ◽  
pp. 6441-6442 ◽  
Author(s):  
Isao Hirata ◽  
Hiroo Iwata ◽  
Abu Bakar Md. Ismail ◽  
Hiroshi Iwasaki ◽  
Tetsuo Yukimasa ◽  
...  
Keyword(s):  
Surface Modification ◽  
Living Cells ◽  
Silicon Plate
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