scholarly journals Rational drug design, synthesis, and biological evaluation of novel chiral tetrahydronaphthalene-fused spirooxindole as MDM2-CDK4 dual inhibitor against glioblastoma

2020 ◽  
Vol 10 (8) ◽  
pp. 1492-1510 ◽  
Author(s):  
Biao Wang ◽  
Fu Peng ◽  
Wei Huang ◽  
Jin Zhou ◽  
Nan Zhang ◽  
...  
Keyword(s):  
Drug Design ◽  
Biological Evaluation ◽  
Rational Drug Design ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
Rational Drug ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of caffeoyl benzanilides as dual inhibitors of HIV integrase and CCR5

MedChemComm ◽  
2016 ◽  
Vol 7 (10) ◽  
pp. 2028-2032 ◽  
Author(s):  
Xuefeng Sun ◽  
Ningning Fan ◽  
Weisi Xu ◽  
Yixing Sun ◽  
Xin Xie ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Hiv Integrase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
Dual Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Hiv 1

Novel series of caffeoyl benzanilides have been synthesized and evaluated as dual inhibitors of HIV-1 CCR5/IN. Compound 9a exhibited the possibility of being a dual inhibitor of HIV-1.

scholarly journals Novel Anthranilamide-Based FXa Inhibitors: Drug Design, Synthesis and Biological Evaluation

Molecules ◽  
2016 ◽  
Vol 21 (4) ◽  
pp. 491 ◽  
Author(s):  
Wenzhi Wang ◽  
Jing Yuan ◽  
Xiaoli Fu ◽  
Fancui Meng ◽  
Shijun Zhang ◽  
...  
Keyword(s):  
Drug Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation

2015 ◽  
Vol 25 (20) ◽  
pp. 4557-4561 ◽  
Author(s):  
Zhouling Xie ◽  
Youli Zhou ◽  
Wei Zhao ◽  
He Jiao ◽  
Yu Chen ◽  
...  
Keyword(s):  
Drug Design ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Parp 1
Sign in / Sign up

Export Citation Format

Share Document