scholarly journals Age-Related Differences in Lower-Limb Muscle Cross-Sectional Area and Torque Production in Boys With Duchenne Muscular Dystrophy

2010 ◽  
Vol 91 (7) ◽  
pp. 1051-1058 ◽  
Author(s):  
Sunita Mathur ◽  
Donovan J. Lott ◽  
Claudia Senesac ◽  
Sean A. Germain ◽  
Ravneet S. Vohra ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Lower Limb ◽  
Cross Sectional Area ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Sectional Area ◽  
Cross Sectional ◽  
Age Related ◽  
Muscle Cross Sectional Area

Mid-thigh cross-sectional area and lower limb muscle function in patients with lung cancer

2015 ◽  
Author(s):  
Valerie Coats ◽  
Fernanda Ribeiro ◽  
Lise Tremblay ◽  
Brigitte Fortin ◽  
François Maltais ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lower Limb ◽  
Muscle Function ◽  
Cross Sectional Area ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Sectional Area ◽  
Cross Sectional

scholarly journals Age-Related Declines in Lower Limb Muscle Function are Similar in Power and Endurance Athletes of Both Sexes: A Longitudinal Study of Master Athletes

2021 ◽  
Author(s):  
Alex Ireland ◽  
Uwe Mittag ◽  
Hans Degens ◽  
Dieter Felsenberg ◽  
Ari Heinonen ◽  
...  
Keyword(s):  
Lower Limb ◽  
Muscle Function ◽  
Peak Power ◽  
Muscle Power ◽  
Endurance Athletes ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Master Athletes ◽  
Cross Sectional ◽  
Age Related

AbstractThe age-related decline in muscle function, particularly muscle power, is associated with increased risk of important clinical outcomes. Physical activity is an important determinant of muscle function, and different types of physical activity e.g. power-based versus endurance-based exercise appear to have differential effects on muscle power. Cross-sectional studies suggest that participation in power-based exercise is associated with greater muscle power across adulthood but this has not been investigated longitudinally. We recruited eighty-nine male and female power and endurance master athletes (sprint and distance runners respectively, baseline age 35–90y). Using jumping mechanography, we measured lower limb muscle function during a vertical jump including at least two testing sessions longitudinally over 4.5 ± 2.4y. We examined effects of time, discipline (power/endurance) and sex in addition to two- and three-way interactions using linear mixed-effects models. Peak relative power, relative force and jump height, but not Esslingen Fitness Index (indicating peak power relative to sex and age-matched reference data) declined with time. Peak power, force, height and EFI were greater in power than endurance athletes. There were no sex, discipline or sex*discipline interactions with time for any variable, suggesting that changes were similar over time for athletes of both sexes and disciplines. Advantages in lower limb muscle function in power athletes were maintained with time, in line with previous cross-sectional studies. These results suggest that improvements in lower limb function in less active older individuals following power-based training persist with continued adherence, although this requires further investigation in interventional studies.

scholarly journals Overexpression of HSP10 in skeletal muscle of transgenic mice prevents the age-related fall in maximum tetanic force generation and muscle cross-sectional area

2010 ◽  
Vol 299 (1) ◽  
pp. R268-R276 ◽  
Author(s):  
Anna C. Kayani ◽  
Graeme L. Close ◽  
Wolfgang H. Dillmann ◽  
Ruben Mestril ◽  
Malcolm J. Jackson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Cross Sectional Area ◽  
Force Generation ◽  
Sectional Area ◽  
Wild Type ◽  
Cross Sectional ◽  
Tetanic Force ◽  
Age Related ◽  
Muscle Cross Sectional Area

Skeletal muscle atrophy and weakness are major contributors to frailty and impact significantly on quality of life of older people. Muscle aging is characterized by a loss of maximum tetanic force (Po) generation, primarily due to muscle atrophy, to which mitochondrial dysfunction is hypothesized to contribute. We hypothesized that lifelong overexpression of the mitochondrial heat shock protein (HSP) HSP10 in muscle of mice would protect against development of these deficits. Po generation by extensor digitorum longus muscles of adult and old wild-type and HSP10-overexpressing mice was determined in situ. Muscles were subjected to damaging lengthening contractions, and force generation was remeasured at 3 h or 28 days to examine susceptibility to, and recovery from, damage, respectively. Muscles of old wild-type mice had a 23% deficit in Po generation and a 10% deficit in muscle cross-sectional area compared with muscles of adult wild-type mice. Overexpression of HSP10 prevented this age-related fall in Po generation and reduction in cross-sectional area observed in muscles of old wild-type mice. Additionally, overexpression of HSP10 protected against contraction-induced damage independent of age but did not improve recovery if damage occurred. Preservation of muscle force generation and CSA by HSP10 overexpression was associated with protection against the age-related accumulation of protein carbonyls. Data demonstrate that development of age-related muscle weakness may not be inevitable and show, for the first time, that lifelong overexpression of an HSP prevents the age-related loss of Po generation. These findings support the hypothesis that mitochondrial dysfunction is involved in the development of age-related muscle deficits.

Gait deviations in children with Duchenne Muscular Dystrophy can be directly attributed to muscle weakness in two lower limb muscle groups

2017 ◽  
Vol 57 ◽  
pp. 38-39
Author(s):  
Marije Goudriaan ◽  
Catherine Huenaerts ◽  
Marleen Van den Hauwe ◽  
Guy Molenaers ◽  
Nathalie Goemans ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Muscle Weakness ◽  
Lower Limb ◽  
Lower Limb Muscle ◽  
Limb Muscle ◽  
Muscle Groups
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