scholarly journals Anti-Parasitic Activity of Myristica Fragrans Houtt. Essential Oil Against Toxoplasma Gondii Parasite

2012 ◽  
Vol 2 ◽  
pp. 92-96 ◽  
Author(s):  
Suthagar Pillai ◽  
Roziahanim Mahmud ◽  
Wei Cai Lee ◽  
Shanmugapriya Perumal
Keyword(s):  
Toxoplasma Gondii ◽  
Essential Oil ◽  
Myristica Fragrans ◽  
Parasitic Activity ◽  
Myristica Fragrans Houtt

scholarly journals Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 565 ◽  
Author(s):  
Mohamed A. Ibrahim ◽  
Charles L. Cantrell ◽  
Ekaterina A. Jeliazkova ◽  
Tess Astatkie ◽  
Valtcho D. Zheljazkov
Keyword(s):  
Plasmodium Falciparum ◽  
Essential Oil ◽  
Seed Oil ◽  
Antimalarial Activity ◽  
Chemical Compositions ◽  
Pharmacological Effects ◽  
Substantial Variation ◽  
Myristica Fragrans ◽  
Oil Fractions ◽  
Myristica Fragrans Houtt

The intent of this study was to utilize distillation timeframes (DT) of nutmeg (Myristica fragrans) essential oil (EO) to generate fractions with differential chemical compositions and bioactivity. Ten fractions were captured at the following distillation timeframes: 0.0–0.5, 0.5–1.0, 1.0–2.5, 2.5–5.0, 5.0–10, 10–30, 30–60, 60–90, 90–120, and 120–240 min. In addition, a control EO was collected from a straight 0–240 min non-stop distillation. ANOVA and advanced regression modeling revealed that the produced EO fractions possess substantial variation in the concentration of potentially desired compounds. The concentrations (%) of α-phellandrene, 3-carene, p-cymene, limonene, α-thujene, α-pinene, camphene, sabinene, β-pinene, and myrcene decreased, while the concentrations (%) of α-terpinene, γ-terpinene, terpinolene, and myristicin increased in later DT fractions. Nutmeg EO showed some antimalarial activity against Plasmodium falciparum D6, but did not exhibit significant antifungal activity. In general, nutmeg seed oil yields increased with an increase of DT. These results may be utilized by industries using nutmeg EO.

scholarly journals Larvicidal Activity of Essential Oils from the Leaves and Fruits of Nutmeg (Myristica fragrans Houtt) Against Aedes aegypti (Diptera: Culicidae)

2016 ◽  
Vol 4 (7) ◽  
pp. 552
Author(s):  
Anne Carolina ◽  
Maman Maman
Keyword(s):  
Essential Oil ◽  
Aedes Aegypti ◽  
Larvicidal Activity ◽  
Steam Distillation ◽  
Chemical Compounds ◽  
Chemical Components ◽  
Myristica Fragrans ◽  
Leaf Oil ◽  
Myristica Fragrans Houtt ◽  
Fruit Oil

The aim of this research was to examine the larvicidal activity of essential oil (EO) extracted from nutmeg (Myristica fragrans Houtt) leaves and fruits by steam distillation, and to analyze its chemical compounds. The EO yield of nutmeg leaves and fruits collected from the same tree was 0.66% and 0.30%, respectively. Larvicidal tests with the EO were carried out against Aedes aegypti (L.) (Diptera: Culicidae). The concentrations of nutmeg EO used for the larvicidal assay were 50, 100, 150, 200, and 250 μg/mL. The results showed that fruit oil was more toxic than the leaf oil. LC50 values of leaf and fruit EOs were 133.8 and 110.1 µg/mL, respectively. The chromatogram of GC-MS showed that the chemical components in nutmeg leaf and fruit EOs were dominated by α-pinene, sabinene, β-pinene, delta-3-carene, limonene, β-phellandrene, α-terpinolene, linalool, safrole, croweacin, and myristicin.

scholarly journals A Review on Chemical Composition, Bioactivity, and Toxicity of Myristica fragrans Houtt. Essential Oil

2021 ◽  
pp. 304-313
Author(s):  
Mega Ferdina Warsito
Keyword(s):  
Essential Oil ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Chemical Compounds ◽  
Volatile Oil ◽  
Natural Medicine ◽  
Myristica Fragrans ◽  
Biological Potency ◽  
Myristica Fragrans Houtt ◽  
Nutmeg Essential Oil

Myristica fragrans Houtt., commonly known as nutmeg, is an Indonesian indigenous dioecious evergreen tree which contains 5-15% volatile oil. The oil is usually produced from the seed or mace.  Nutmeg oil has been extensively utilized in aromatherapy, natural medicine, and the perfume industry. This article provides an overview of the chemical compounds, biological potency, and toxic effects of nutmeg essential oil compiled from recent literature (2000–2020). Nutmeg oil mainly comprises monoterpenes and phenylpropanoids. Several reports on gas chromatography-mass spectrophotometry analysis of nutmeg oil showed that there were 27–38 chemical constituents detected at various concentrations. Many secondary metabolites of nutmeg oil reported to show biological activities that possibly substantiate its utilization in natural medicine. Numerous studies reported the biological activities of this volatile oil such as antioxidant, analgesic, antiinflammation, anticonvulsant, antibacterial, antiparasitic, insecticidal, and anticancer activity. But large intake of nutmeg oil could cause intoxication which is shown through symptoms in cardiovascular, central nervous system, anticholinergic, and local effects in the stomach. These symptoms are mainly attributed to the effect of myristicin, safrole, and elemicin overdose. This updated review paper intends to attract more attention to nutmeg oil and its potential to be developed into a medicinal product for the prophylaxis and therapy of diseases.

COMPOSITION AND ANTIFUNGAL ACTIVITY OF THE BRAZILIAN MYRISTICA FRAGRANS HOUTT ESSENTIAL OIL

2011 ◽  
Vol 31 (2) ◽  
pp. 197-202 ◽  
Author(s):  
VÂNIA MARIA MOREIRA VALENTE ◽  
GULAB NEWANDRAM JHAM ◽  
ONKAR DEV DHINGRA ◽  
ION GHIVIRIGA
Keyword(s):  
Antifungal Activity ◽  
Essential Oil ◽  
Myristica Fragrans ◽  
Myristica Fragrans Houtt

Characterization and Optimization of Microwave Assisted Process for Extraction of Nutmeg (Myristica fragrans Houtt.) Mace Essential Oil

2018 ◽  
Vol 21 (4) ◽  
pp. 895-904 ◽  
Author(s):  
Nukasani Sagarika ◽  
M.V. Prince ◽  
Anjineyulu Kothakota ◽  
R. Pandiselvam ◽  
R. Sreeja ◽  
...  
Keyword(s):  
Essential Oil ◽  
Microwave Assisted ◽  
Myristica Fragrans ◽  
Myristica Fragrans Houtt

scholarly journals Pengaruh Lama Penyulingan terhadap Rendemen dan Mutu Minyak Atsiri pada Biji Pala (Myristica fragrans Houtt)

2018 ◽  
Vol 11 (1) ◽  
pp. 50-58
Author(s):  
Fadillah Ramadhanti Rangkuti ◽  
Raida Agustina ◽  
Mustaqimah Mustaqimah ◽  
Mustafril Mustafril
Keyword(s):  
Refractive Index ◽  
Essential Oil ◽  
High Refractive Index ◽  
The Other ◽  
A Value ◽  
Myristica Fragrans ◽  
Weight Value ◽  
Myristica Fragrans Houtt ◽  
Index Value

Abstrak. Pala merupakan salah satu tanaman rempah yang menghasilkan minyak atsiri. Penelitian ini bertujuan untuk mengetahui pengaruh lama penyulingan terhadap rendemen dan mutu minyak biji pala. Variasi perlakuan yang digunakan adalah lama penyulingan yaitu 0-3 jam, 3-6 jam, 6-9 jam, 9-12 jam, 12-15 jam, 15-18 jam, 18-21 jam, 21-24 jam, 24-27 jam, dan 27-30 jam. Analisis karakteristik yang dilakukan meliputi rendemen, bobot jenis, indeks bias dan kelarutan dalam alkohol. Hasil penelitian yang telah dilakukan didapat rendemen minyak pala yang bervariasi, tergantung dari lama penyulingan. Pada jam ke 3 menghasilkan rendemen yang lebih besar dibandingkan dengan jam yang lain, dimana rendemen minyak pala pada jam ke 3 didapat sebesar 5,58 % sedangkan rendemen yang paling rendah terdapat pada jam ke 30 dengan hasil sebesar 0.12%. Berdasarkan hasil perhitungan rendemen kumulatif yang didapat dari range waktu 0-3, 3-6, 6-9, 9-12, 12-15, 15-18, 18-21, 21-24, 24-27, dan 27-30 adalah sebesar 10, 48 %. Nilai bobot jenis minyak pala yang diperoleh dari hasil penyulingan pada jam ke 24 menunjukkan angka yang lebih tinggi dibandingkan hasil yang lainnya dengan nilai 0,936 dan tidak memenuhi standar SNI. Sedangkan yang paling rendah terdapat pada jam ke 3 dengan nilai 0.872 yang juga tidak sesuai dengan standar SNI. Penyulingan dengan nilai bobot jenis yang sesuai dengan standar SNI terdapat pada jam ke 6 dengan nilai 0,902. Nilai indeks bias yang tinggi didapatkan pada jam ke 12- 15, 18-21, 21-24 dan 24- 27 dengan nilai 1,496 dan memenuhi standar SNI sedangkan pada jam ke 3-6 diperoleh nilai indeks bias sebesar 1,436 dan tidak memenuhi standar SNI. Tingkat kelarutan dalam alkohol 90% minyak pala yang dihasilkan dari 6 jam sampai 30 jam adalah sama, yaitu jernih yang diuji dengan perbandingan 1:3 dan sudah sesuai standar SNI sedangkan pada ke 3 jam hasilnya adalah opalisensi yaitu tidak keruh dan tidak jernih. Effect of Old Distillation on Rendemen and Quality of Essential Oils on Nutmeg (Myristica fragrans Houtt) Abstract. Nutmeg is one of the herbs that produce essential oil. This study aims to determine the effect of distillation on rendemen and quality of nutmeg oil. The variation of treatment used was the distillation time of 0-3 hours, 3-6 hours, 6-9 hours, 9-12 hours, 12-15 hours, 15-18 hours, 18-21 hours, 21-24 hours, 24- 27 hours, and 27-30 hours. Characteristic analyzes performed include rendemen, species weight, refractive index and solubility in alcohol. The results of the research have been obtained the yield of various nutmeg oil, depending on the length of distillation. At third hours it produces a higher yield compared to the other hour, where the yield of nutmeg oil at third hourswas5.58%, while the lowest yield was at 30thhours with a yield of 0.12%. Based on the results of cumulative rendemen calculations obtained from the range of time 0-3, 3-6, 6-9, 9-12, 12-15, 15-18, 18-21, 21-24, 24-27, and 27-30 was 10, 48%. The weight value of nutmeg oil obtained from the distillation at 24 hours indicates a higher rate than the other results with a value of 0.936 and didn't meet the SNI standard. While the lowest was at third hours with a value of 0.872 which was also not in accordance with SNI standards. Distillation with value of weight of type according to SNI standard is at 6th hours with value 0,902. High refractive index values were obtained at 12 to 15, 18-21, 21-24 and 24-27 hours with a value of 1.496 and met the SNI standard while at 3-6 hours the refractive index value was 1.436 and did not meet the SNI standard. The solubility rate in 90% alcohol of nutmeg oil produced from 6th hours to 30th hours is the same, that was clear tested with ratio of 1: 3 and was accordance with SNI standard while in 3 hours the result is opalisensi that is not cloudy and not clear.

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