Association of ApoE gene with type 2 diabetic nephropathy in a Chinese population: A meta-analysis of case-control studies

2015 ◽  
Vol 76 (5) ◽  
pp. 601-613
Author(s):  
Cheng Zhang ◽  
Shengbing Li ◽  
Xianxiang Zhang ◽  
Hua Liu ◽  
Yong Luo
Keyword(s):  
Diabetic Nephropathy ◽  
Chinese Population ◽  
Meta Analysis ◽  
Case Control ◽  
Apoe Gene ◽  
Case Control Studies ◽  
Type 2 Diabetic

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

2021 ◽  
Vol 53 (05) ◽  
pp. 293-300
Author(s):  
Rui Wang ◽  
Hongyan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Lower Serum ◽  
Matched Case

AbstractIrisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes’ Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48–1.77, p<0.001; I2=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93–2.79, p<0.001; I2=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microalbuminuria (10 studies, SMD: 0.91, 95% CI: 0.44–1.38, p<0.001; I2=90%). In addition, patients with estimated glomerular infiltration rate (eGFR)<60 ml/min 1.73 m2 had lower serum irisin compared to those with eGFR≥60 ml/min 1.73 m2 (4 studies, SMD: 0.89, 95% CI: 0.32–1.46, p=0.002; I2=91%). In conclusion, serum irisin may be associated with albuminuria and reduced eGFR in T2DM patients.

scholarly journals Prediabetes Is Associated withHNF-4αP2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Changyi Wang ◽  
Sihan Chen ◽  
Tao Zhang ◽  
Zhongwei Chen ◽  
Shengyuan Liu ◽  
...  
Keyword(s):  
Chinese Population ◽  
Case Control Study ◽  
Meta Analysis ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Nuclear Factor ◽  
Hepatocyte Nuclear Factor ◽  
P2 Promoter ◽  
Control Study

Background. Controversy remains for the association between hepatocyte nuclear factor4α(HNF-4α) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk.Methods. Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 ofHNF-4αin the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall contribution of rs1884613 to T2D risk.Results. Polymorphism rs1884613 was associated with genetic susceptibility to prediabetes in the whole samples (OR = 1.40, 95% CI = 1.16–1.68,P=0.0001) and the female subgrouped samples (OR = 1.48, 95% CI = 1.14–1.92,P=0.003) after adjusting for age and body mass index (BMI). In contrast, there was no association of rs1884613 with T2D in the whole samples and male in our case-control study and meta-analysis.Conclusions. Our results suggest that rs1884613 contributes to susceptibility to prediabetes, whereas this polymorphism may not play an important role in the development of T2D.

Association between a Lumican Promoter Polymorphism and High Myopia in the Chinese Population: A Meta-Analysis of Case-Control Studies

2014 ◽  
Vol 232 (2) ◽  
pp. 110-117 ◽  
Author(s):  
Zhu-Jun Deng ◽  
Ke-Qing Shi ◽  
Yi-Jiang Song ◽  
Yu-Xiao Fang ◽  
Jianmin Wu ◽  
...  
Keyword(s):  
Chinese Population ◽  
High Myopia ◽  
Meta Analysis ◽  
Promoter Polymorphism ◽  
Case Control ◽  
Case Control Studies

The Effect of KCNJ11 Polymorphism on the Risk of Type 2 Diabetes: A Global Meta-Analysis Based on 49 Case-Control Studies

2012 ◽  
Vol 31 (5) ◽  
pp. 801-810 ◽  
Author(s):  
Bo Gong ◽  
Jing Yu ◽  
Haichuan Li ◽  
Wenjiao Li ◽  
Xinghai Tong
Keyword(s):  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Relationship betweenPPARγ Pro12Alagene polymorphism and type 2 diabetic nephropathy risk in Asian population: results from a meta-analysis

2013 ◽  
Vol 34 (2) ◽  
pp. 131-136 ◽  
Author(s):  
Guohui Liu ◽  
Tian-Biao Zhou ◽  
Zongpei Jiang ◽  
Dongwen Zheng ◽  
Fei Yuan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Asian Population ◽  
Type 2 Diabetic

scholarly journals Urine transferrin as an early endothelial dysfunction marker in type 2 diabetic patients without nephropathy: a case control study.

2021 ◽  
Author(s):  
José Juan Sánchez-Hidalgo ◽  
Juan Antonio SUÁREZ-CUENCA ◽  
José Juan Lozano-Nuevo ◽  
Víctor Hugo García-López ◽  
María Graciela Leal-Gutiérrez ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Endothelial Dysfunction ◽  
Case Control Study ◽  
Case Control ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Early Diabetic Nephropathy ◽  
Type 2 Diabetic ◽  
Control Study

Abstract Background Albumin, along with other proteins, is abnormally eliminated via the urine during early stages of diabetic nephropathy. Moreover, endothelial dysfunction (ED) accompanying early diabetic nephropathy may develop even before microalbuminuria is detectable. Transferrin has a molecular weight comparable to albumin, and transferrinuria and microalbuminuria in a 24-hour urine sample may comparably reflect early diabetic nephropathy. However, transferrin physiochemical properties may be related with ED, but these have not been elucidated yet. This case-control study was aimed to evaluate relation between ED and urinary transferrin concentration before early diabetic nephropathy is present. Methods Patients were enrolled from two study sites in Mexico City: Ticoman General Hospital to evaluate control patients; and Dr. Manuel Gonzalez Rivera Specialized Clinic for the Management of the Diabetic Patient for case patients. All patients provided written informed consent. The primary endpoint was the correlation between urinary transferrin concentration and endothelial dysfunction measured in type 2 diabetic patients without albuminuria. ED was evaluated by ultrasonographic validated measurements, which included carotid intima-media thickness (CIMT) and flow mediated dilation (FMD). A power calculation, to detect a statistical difference, with a p value of 0.05, mandated a sample of 60 patients. The patients were tested for serum biomarkers such as glycated hemoglobin, creatinine, cholesterol, triglycerides, and urinary dipstick for albuminuria and urinary tract infection; using inclusion, exclusion and elimination criteria as described. Results The group with type 2 diabetes was older and showed higher serum transferrin and lower urinary transferrin values. Likewise, the group with type 2 diabetes showed subclinical atherogenic risk characterized by lower FMD and higher CIMT and ABI values. Risk factors associated to endothelial dysfunction measured by CIMT were time from diagnosis of diabetes, insulin resistance, dyslipidemia, and male sex. Hba1c and time since diabetes diagnosis correlated both for risk associated to FMD and CIMT. CIMT was the only factor correlated with urinary transferrin values. Conclusion Urinary transferrin correlated to subclinical endothelial dysfunction measured by CIMT in type 2 diabetic patients without nephropathy and can be used to test for early nephropathy in patients without albuminuria.

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