The Effect of KCNJ11 Polymorphism on the Risk of Type 2 Diabetes: A Global Meta-Analysis Based on 49 Case-Control Studies

2012 ◽  
Vol 31 (5) ◽  
pp. 801-810 ◽  
Author(s):  
Bo Gong ◽  
Jing Yu ◽  
Haichuan Li ◽  
Wenjiao Li ◽  
Xinghai Tong
Keyword(s):  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis

2021 ◽  
Vol 53 (05) ◽  
pp. 293-300
Author(s):  
Rui Wang ◽  
Hongyan Liu
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Lower Serum ◽  
Matched Case

AbstractIrisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Matched case-control studies evaluating the difference of serum irisin between T2DM patients with and without DN were identified via systematic search of PubMed, Embase, Cochranes’ Library, China National Knowledge Infrastructure, and WanFang databases from inception to December 5, 2020. A random-effects model or a fixed-effects model was used to pool the results according to the heterogeneity. Overall, thirteen matched case-control studies including 1735 T2DM patients were included. Results of meta-analysis showed that compared to T2DM patients with normoalbuminuria, those with microalbuminuria [10 studies, standard mean difference (SMD): 1.12, 95% confidence interval (CI): 0.48–1.77, p<0.001; I2=94%] and macroalbuminuria (10 studies, SMD: 1.86, 95% CI: 0.93–2.79, p<0.001; I2=97%) had significantly lower serum irisin. Besides, the serum level of irisin was significantly lower in T2DM patients with macroalbuminuria than those with microalbuminuria (10 studies, SMD: 0.91, 95% CI: 0.44–1.38, p<0.001; I2=90%). In addition, patients with estimated glomerular infiltration rate (eGFR)<60 ml/min 1.73 m2 had lower serum irisin compared to those with eGFR≥60 ml/min 1.73 m2 (4 studies, SMD: 0.89, 95% CI: 0.32–1.46, p=0.002; I2=91%). In conclusion, serum irisin may be associated with albuminuria and reduced eGFR in T2DM patients.

scholarly journals Testosterone level and risk of type 2 diabetes in men: a systematic review and meta-analysis

2018 ◽  
Vol 7 (1) ◽  
pp. 220-231 ◽  
Author(s):  
Qiu-ming Yao ◽  
Bin Wang ◽  
Xiao-fei An ◽  
Jin-an Zhang ◽  
Liumei Ding
Keyword(s):  
Type 2 Diabetes ◽  
Testosterone Level ◽  
Meta Analysis ◽  
Free Testosterone ◽  
Case Control ◽  
Total Testosterone ◽  
Testosterone Deficiency ◽  
Case Control Studies ◽  
Nested Case Control

Background Type 2 diabetes is a risk factor for testosterone deficiency and impaired sex steroid status. Some studies also investigated the association of testosterone level with diabetes risk in men, but reported controversial findings. To clarify this issue, we conducted a systematic review and meta-analysis. Methods PubMed, EMBASE and Web of Science were searched for eligible cohort or nested case–control studies published up to August 15, 2017. Meta-analysis was used to calculate the pooled relative risk (RR) of type 2 diabetes associated with higher testosterone level. Results Thirteen cohort or nested case–control studies with 16,709 participants were included. Meta-analysis showed that higher total testosterone level could significantly decrease the risk of type 2 diabetes in men (RR = 0.65; 95% CI 0.50–0.84; P = 0.001), and higher free testosterone level could also decrease the risk of type 2 diabetes in men (RR = 0.94; 95% CI 0.90–0.99; P = 0.014). After excluding two studies that did not calculate RRs by quartiles of testosterone levels, both higher total testosterone and free testosterone levels could decrease the risk of type 2 diabetes in men, and the pooled RRs were 0.62 (95% CI 0.51–0.76; P < 0.001) and 0.77 (95% CI 0.61–0.98; P = 0.03), respectively. Conclusion This meta-analysis suggests that higher testosterone level can significantly decrease the risk of type 2 diabetes in men. Therefore, combined with previous researches, the findings above suggest a reverse-causality scenario in the relation between testosterone deficiency and risk of type 2 diabetes in men.

scholarly journals PPAR 2 P12A polymorphism and albuminuria in patients with type 2 diabetes: a meta-analysis of case-control studies

2011 ◽  
Vol 26 (12) ◽  
pp. 4011-4016 ◽  
Author(s):  
S. De Cosmo ◽  
S. Prudente ◽  
O. Lamacchia ◽  
E. Lapice ◽  
E. Morini ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies
Sign in / Sign up

Export Citation Format

Share Document