scholarly journals Inability to Upregulate Cytochrome P450 4A and 2C Causes Salt Sensitivity in Young Sprague-Dawley Rats

2006 ◽  
Vol 19 (11) ◽  
pp. 1174-1180 ◽  
Author(s):  
S SANKARALINGAM ◽  
K DESAI ◽  
H GLAESER ◽  
R KIM ◽  
T WILSON
Keyword(s):  
Cytochrome P450 ◽  
Salt Sensitivity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Cytochrome P450 4A

scholarly journals Inhibition of microRNA-429 in the renal medulla increased salt sensitivity of blood pressure in Sprague Dawley rats

2017 ◽  
Vol 35 (9) ◽  
pp. 1872-1880 ◽  
Author(s):  
Qing Zhu ◽  
Junping Hu ◽  
Lei Wang ◽  
Weili Wang ◽  
Zhengchao Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Renal Medulla ◽  
Salt Sensitivity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Norepinephrine-evoked salt-sensitive hypertension requires impaired renal sodium chloride cotransporter activity in Sprague-Dawley rats

2016 ◽  
Vol 310 (2) ◽  
pp. R115-R124 ◽  
Author(s):  
Kathryn R. Walsh ◽  
Jill T. Kuwabara ◽  
Joon W. Shim ◽  
Richard D. Wainford
Keyword(s):  
Blood Pressure ◽  
Sodium Chloride ◽  
Salt Sensitivity ◽  
Dietary Sodium ◽  
Ang Ii ◽  
Sprague Dawley ◽  
Sodium Chloride Cotransporter ◽  
Sprague Dawley Rats ◽  
Salt Sensitive Hypertension ◽  
The Impact

Recent studies have implicated a role of norepinephrine (NE) in the activation of the sodium chloride cotransporter (NCC) to drive the development of salt-sensitive hypertension. However, the interaction between NE and increased salt intake on blood pressure remains to be fully elucidated. This study examined the impact of a continuous NE infusion on sodium homeostasis and blood pressure in conscious Sprague-Dawley rats challenged with a normal (NS; 0.6% NaCl) or high-salt (HS; 8% NaCl) diet for 14 days. Naïve and saline-infused Sprague-Dawley rats remained normotensive when placed on HS and exhibited dietary sodium-evoked suppression of peak natriuresis to hydrochlorothiazide. NE infusion resulted in the development of hypertension, which was exacerbated by HS, demonstrating the development of the salt sensitivity of blood pressure [MAP (mmHg) NE+NS: 151 ± 3 vs. NE+HS: 172 ± 4; P < 0.05]. In these salt-sensitive animals, increased NE prevented dietary sodium-evoked suppression of peak natriuresis to hydrochlorothiazide, suggesting impaired NCC activity contributes to the development of salt sensitivity [peak natriuresis to hydrochlorothiazide (μeq/min) Naïve+NS: 9.4 ± 0.2 vs. Naïve+HS: 7 ± 0.1; P < 0.05; NE+NS: 11.1 ± 1.1; NE+HS: 10.8 ± 0.4). NE infusion did not alter NCC expression in animals maintained on NS; however, dietary sodium-evoked suppression of NCC expression was prevented in animals challenged with NE. Chronic NCC antagonism abolished the salt-sensitive component of NE-mediated hypertension, while chronic ANG II type 1 receptor antagonism significantly attenuated NE-evoked hypertension without restoring NCC function. These data demonstrate that increased levels of NE prevent dietary sodium-evoked suppression of the NCC, via an ANG II-independent mechanism, to stimulate the development of salt-sensitive hypertension.

Cytochrome P450 probe substrate metabolism kinetics in Sprague Dawley rats

Xenobiotica ◽  
2007 ◽  
Vol 37 (5) ◽  
pp. 459-473 ◽  
Author(s):  
J. P. Chovan ◽  
S. C. Ring ◽  
E. Yu ◽  
J. P. Baldino
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Substrate Metabolism ◽  
Sprague Dawley Rats

scholarly journals Mechanisms of Oxidative Stress-Induced Increase in Salt Sensitivity and Development of Hypertension in Sprague-Dawley Rats

Hypertension ◽  
2007 ◽  
Vol 49 (3) ◽  
pp. 664-671 ◽  
Author(s):  
Anees Ahmad Banday ◽  
Abdul Bari Muhammad ◽  
Fatima Rizwan Fazili ◽  
Mustafa Lokhandwala
Keyword(s):  
Oxidative Stress ◽  
Salt Sensitivity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Induction of cytochrome p450 1a and 2b by α-and β-lonone in sprague dawley rats

2002 ◽  
Vol 25 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Hye Gwang Jeong ◽  
Young-Jin Chun ◽  
Chul-Ho Yun ◽  
Chang-Kiu Moon ◽  
Hye-Sook Lee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Cytochrome P450 1A

Induction of Liver Cytochrome-P450 2B1 by β-Ionone in Sprague-Dawley Rats

1995 ◽  
Vol 216 (1) ◽  
pp. 198-202 ◽  
Author(s):  
T.C. Jeong ◽  
H.J. Kim ◽  
C.H. Yun ◽  
S.S. Lee ◽  
K.H. Yang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Liver Cytochrome ◽  
Sprague Dawley Rats

scholarly journals Evaluation of Memory Enhancing Clinically Available Standardized Extract of Bacopa monniera on P-Glycoprotein and Cytochrome P450 3A in Sprague-Dawley Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72517 ◽  
Author(s):  
Rajbir Singh ◽  
Jagadeesh Panduri ◽  
Devendra Kumar ◽  
Deepak Kumar ◽  
Hardik Chandsana ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Bacopa Monniera ◽  
Sprague Dawley ◽  
Cytochrome P450 3A ◽  
P Glycoprotein ◽  
Sprague Dawley Rats ◽  
Memory Enhancing
Sign in / Sign up

Export Citation Format

Share Document