Induction of Liver Cytochrome-P450 2B1 by β-Ionone in Sprague-Dawley Rats

1995 ◽  
Vol 216 (1) ◽  
pp. 198-202 ◽  
Author(s):  
T.C. Jeong ◽  
H.J. Kim ◽  
C.H. Yun ◽  
S.S. Lee ◽  
K.H. Yang ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Liver Cytochrome ◽  
Sprague Dawley Rats

Cytochrome P450 probe substrate metabolism kinetics in Sprague Dawley rats

Xenobiotica ◽  
2007 ◽  
Vol 37 (5) ◽  
pp. 459-473 ◽  
Author(s):  
J. P. Chovan ◽  
S. C. Ring ◽  
E. Yu ◽  
J. P. Baldino
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Substrate Metabolism ◽  
Sprague Dawley Rats

Induction of cytochrome p450 1a and 2b by α-and β-lonone in sprague dawley rats

2002 ◽  
Vol 25 (2) ◽  
pp. 197-201 ◽  
Author(s):  
Hye Gwang Jeong ◽  
Young-Jin Chun ◽  
Chul-Ho Yun ◽  
Chang-Kiu Moon ◽  
Hye-Sook Lee ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Cytochrome P450 1A

scholarly journals Chinese soft-shelled turtle egg powder lowers serum cholesterol, increases faecal neutral steroids and bile acid excretion, and up-regulates liver cytochrome P450 mRNA level in rats

2005 ◽  
Vol 94 (3) ◽  
pp. 315-320 ◽  
Author(s):  
Yu Huanling ◽  
Li Yong ◽  
Wang Junbo ◽  
Zheng Liping ◽  
Yan Weixing
Keyword(s):  
High Fat Diet ◽  
Mrna Level ◽  
Acid Excretion ◽  
Sprague Dawley ◽  
High Fat ◽  
Liver Cytochrome ◽  
Sprague Dawley Rats ◽  
Egg Powder ◽  
Total Bile Acids ◽  
Cholesterol Lowering Effect

The aim of the present study was to investigate the effect of Chinese soft-shelled turtle whole egg powder (TE) on cholesterol metabolism in Sprague–Dawley rats to determine whether it has a cholesterol-lowering effect. Forty male Sprague–Dawley rats were fed a high-fat diet supplemented with TE (0, 0·75, 1·50 or 3·00 g/kg body weight) administrated by gavage for 24 weeks. Serum total cholesterol (TC), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and faecal total bile acids levels were determined by enzymatic methods. Faecal steroid concentrations were measured by GC. Means and standard deviations were calculated where appropriate for values, and the data were tested by one-way ANOVA. After 24 weeks of feeding a high-fat diet with TE supplementation, serum TC and LDL-C levels, liver cholesterol and liver lipid levels were reduced in rats. TE supplementation did not affect the faecal output, but significantly increased steroid concentrations in faeces, indicating increased steroids excretion. The faecal bile acid excretion was also increased as evidence by elevated mRNA level of liver cytochrome P450, family 7, subfamily A, polypeptide 1. Our results demonstrated that the TE does have a cholesterol-lowering effect by increasing the excretion of total bile acids and neutral steroids.

Effects of a new neuroprotective agent KR-31378 on liver cytochrome P450s in male sprague dawley rats

2003 ◽  
Vol 26 (10) ◽  
pp. 800-804
Author(s):  
Tae Cheon Jeong ◽  
Ji-Young Kim ◽  
Hye Young Ji ◽  
Dong Ha Lee ◽  
Sun-Ok Kim ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Sprague Dawley ◽  
Neuroprotective Agent ◽  
Liver Cytochrome ◽  
Sprague Dawley Rats

scholarly journals Evaluation of Memory Enhancing Clinically Available Standardized Extract of Bacopa monniera on P-Glycoprotein and Cytochrome P450 3A in Sprague-Dawley Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e72517 ◽  
Author(s):  
Rajbir Singh ◽  
Jagadeesh Panduri ◽  
Devendra Kumar ◽  
Deepak Kumar ◽  
Hardik Chandsana ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Bacopa Monniera ◽  
Sprague Dawley ◽  
Cytochrome P450 3A ◽  
P Glycoprotein ◽  
Sprague Dawley Rats ◽  
Memory Enhancing

Effect of Cellgevity® Supplement on Selected Rat Liver Cytochrome P450 Enzyme Activity and Pharmacokinetic Parameters of Carbamazepine

2020 ◽  
Author(s):  
Seth Kwabena Amponsah ◽  
Benoit Banga Nguessan ◽  
Martin Akandawen ◽  
Abigail Aning ◽  
Sedem Yawa Agboli ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Cytochrome P450 ◽  
Rat Liver ◽  
Normal Saline ◽  
Pharmacokinetic Parameters ◽  
Cytochrome P450 Enzyme ◽  
Sprague Dawley ◽  
Serum Samples ◽  
Liver Cytochrome ◽  
Sd Rats

Abstract Background: There is considerable evidence that many patients concurrently administer dietary supplements with conventional drugs, creating a risk for potential drug-supplement interaction. The aim of this study was to determine the effect of Cellgevity® supplement on selected rat liver cytochrome P450 (CYP) enzymes. Also, we sought to deternine the effect of Cellgevity® on the pharmacokinetics of carbamazepine, a CYP3A4 substrate. Methods: Male Sprague-Dawley (SD) rats were randomly put into 5 groups and administered (per os) either distilled water (negative control), Cellgevity® (3 separate doses) or phenobarbital (positive control). Modulation of liver CYP enzyme activity was evaluated after 30 days of treatment, using probe substrates, spectroscopic and high-performance liquid chromatographic methods. In the pharmacokinetic study, 12 SD rats were divided into 2 groups administered (per os) carbamazepine plus Cellgevity®, or carbamazepine plus normal saline, both over a period of 14 days. Blood samples from rats in the same group were collected after treatment. Serum samples were prepared and pooled together at each specific sampling time point. Levels of carbamazepine were determined using a fluorescence polarization immunoassay. Results: Activities of rat liver CYP1A1/2, CYP2C9 and CYP2D6 were significantly increased by Cellgevity® after 30-day treament. Pharmacokinetic parameters for rats administered carbamazepine with Cellgevity® vis-a-vis carbamazepine with normal saline were as follows: Cmax; 20 μmol/L vs 11 μmol/L, AUC0→24; 347 μmol.h/L vs 170 μmol.h/L, Ke; 0.28 h-1 vs 0.41 h-1, and t1/2; 2.3 h vs 1.7 h, respectively.Conclusions: Cellgevity® increased the activity of rat CYP1A1/2, CYP2C9 and CYP2D6 enzymes, and altered the pharmacokinetics of carbamazepine in rats.

Effect Of 30-Day Administration Of Cellgevity® Supplement On Selected Rat Liver Cytochrome P450 Enzyme Activity And Supplement Interaction With Carbamazepine

2019 ◽  
Author(s):  
Seth Kwabena Amponsah ◽  
Benoit Banga Nguessan ◽  
Martin Akandawen ◽  
Abigail Aning ◽  
Sedem Yawa Agboli ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Cytochrome P450 ◽  
Rat Liver ◽  
Normal Saline ◽  
Pharmacokinetic Parameters ◽  
Control Group ◽  
Cytochrome P450 Enzyme ◽  
Sprague Dawley ◽  
Liver Cytochrome ◽  
Sd Rats

Abstract BackgroundThere is considerable evidence that many patients concurrently take dietary supplements with conventional drugs, with a risk of potential drug-supplement interaction. The aim of this study was to determine the effect of Cellgevity® supplement on selected rat liver cytochrome P450 (CYP) enzymes and on the pharmacokinetics of carbamazepine.MethodsSprague-Dawley (SD) rats were put into 5 groups and modulation of CYP enzyme activity by Cellgevity® was determined by comparing the enzyme activity of Cellgevity-treated groups with the negative control group after 30 days of treatment. For the effect of Cellgevity® on the pharmacokinetics of carbamazepine, 12 SD rats were put into 2 groups; one group received an oral administration of carbamazepine plus Cellgevity®, and the other carbamazepine plus normal saline. Blood samples were collected at specific time points and analyzed for levels of carbamazepine. ResultsActivities of CYP1A1/2, CYP2C9 and CYP2D6 were significantly increased by Cellgevity®. The pharmacokinetic parameters for rats administered carbamazepine with Cellgevity® vis-a-vis carbamazepine with normal saline were changed as follows: Cmax; 20 μmol/L vs 11 μmol/L, AUC0→24; 347 μmol.h/L vs 170 μmol.h/L, Ke; 0.28 h-1 vs 0.41 h-1, and t1/2; 2.3 h vs 1.7 h, respectively.ConclusionsCellgevity® increased the activity of rat CYP1A1/2, CYP2C9 and CYP2D6, and also altered the pharmacokinetics of carbamazepine in rats.

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