scholarly journals Erectile dysfunction is related to systolic blood pressure even in the normal blood pressure levels

2005 ◽  
Vol 18 (5) ◽  
pp. A105-A105
Author(s):  
M DOUMAS ◽  
A TSAKIRIS ◽  
S DOUMA ◽  
A HOUNTA ◽  
A PAPADOPOULOS ◽  
...  
2005 ◽  
Vol 94 (1) ◽  
pp. 84-91 ◽  
Author(s):  
Seiichi Mizuno ◽  
Keiichi Matsuura ◽  
Takanobu Gotou ◽  
Shingo Nishimura ◽  
Osami Kajimoto ◽  
...  

We describe a clinical trial to study the efficacy of a casein hydrolysate, prepared using an Aspergillus oryzae protease, containing the major angiotensin-I-converting enzyme inhibitory peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) in a single-blind, placebo-controlled study. A total of 131 volunteers with high-normal blood pressure and mild hypertension were randomly divided into four groups (n 32 or 33 in each group). Each volunteer was given two tablets containing four different dosages of VPP and IPP (VPP+IPP: 0, 1·8, 2·5 and 3·6 mg), daily for 6 weeks. A significant decrease in systolic blood pressure was observed at 6 weeks in the active group receiving 1·8 mg (P<0·01) VPP and IPP; in the active groups receiving either 2·5 mg or 3·6 mg, systolic blood pressure was decreased at both 3 weeks (P<0·05 and P<0·05) and 6 weeks (P<0·001 and P<0·0001) compared with systolic blood pressure measured before treatment. Changes in the systolic blood pressure after 6 weeks of treatment in the four groups were −1·7, −6·3, −6·7 and −10·1 mmHg, and these effects were dose dependent. In addition, a significant difference in systolic blood pressure between the placebo group and the VPP and IPP group receiving 3·6 mg was observed (P<0·001) by two-way ANOVA. The antihypertensive effect was greater in mildly hypertensive subjects (n 20 or 21 in each group) than in any of the other subjects. No significant change of diastolic blood pressure was observed for all the test groups, and no differences in diastolic blood pressure in the test sample groups compared with the placebo group were observed during the test period.


2016 ◽  
Vol 2 (2) ◽  
pp. 187
Author(s):  
Tawarina Surbakti ◽  
Gilny Aileen Joan ◽  
Denny Ricky

ABSTRAK Penelitian ini dilatarbelakangi hasil penelitian Ramdhani (2013) yang menunjukan adanya perubahan penurunan tekanan darah yaitu setelah dilakukan terapi tertawa selama dua minggu sebanyak enam kali pemberian. Maka peneliti merasa perlu dilakukan uji ulang pemberian terapi tertawa pada tekanan darah normal dengan satu kali pemberian. Tujuan penelitian untuk menganalisis perbedaan tekanan darah sebelum dan sesudah pemberian terapi tertawa pada mahasiswa di Universitas Advent Indonesia. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian eksperimen yang menggunakan One Group Pre-Test and Post-Test Design dengan melibatkan satu kelompok subjek. Intervensi dalam penelitian yang dilakukan ini adalah pemberian terapi tertawa selama 20 menit. Subjek penelitian ini berjumlah 30 orang mahasiswi di Universitas Advent Indonesia. Pengambilan sampel dilakukan dengan teknik purposive sampling. Hasil penelitian ini menunjukan bahwa nilai rata-rata tekanan darah pada mahasiswi di Universitas Advent Indonesia sebelum pemberian terapi tertawa yaitu dengan nilai tekanan darah sistolik adalah  115.6 mmHg dan nilai tekanan darah diastolik 75.0 mmHg. Nilai rata-rata tekanan darah sistolik sesudah pemberian terapi tertawa adalah  110.8 mmHg dan tekanan darah diastolik 73.8  mmHg. Nilai tekanan darah sebelum dan sesudah pemberian terapi tertawa mempunyai nilai yang signifikan pada nilai uji-t pada tekanan sistolik. Tekanan diastolik tidak terjadi perubahan yang signifikan.   Kata kunci: Tekanan darah normal, Terapi tertawa   ABSTRACT This research is based on the writing of Ramdhani (2013) showing that there is a change in blood pressure after given six times laughter therapy for two weeks. Researchers find it necessary to repeat the laugh therapy on person with normal blood pressure with one provision. The purpose of this research is to identify changes in blood pressure before and after given laugh therapy. The research design used in this study is One Group Pre-Test and Post-Test Design experimental research that uses. Intervention conducted in this research is laughing therapy for 20 minutes. Subjects of this research were 30 students of Adventist University of Indonesia. That were by purposive sampling technique. The results of this research showed that the average value of blood pressure in students of Universitas Advent Indonesia before given laugh therapy with a systolic blood pressure value of 115.6 mm Hg and diastolic blood pressure value of 75.0 mmHg. The average value of systolic blood pressure after the administration of laughter therapy was 110.8 mmHg and a diastolic blood pressure value of 73.8 mmHg. Systolic blood pressure values before and after administration of laughter therapy has a significant change but not with the diastolic. Keywords: Normal blood pressure value, Laugh therapy


1927 ◽  
Vol 46 (3) ◽  
pp. 463-485 ◽  
Author(s):  
R. Dominguez

1. Van Leersum's range for the normal blood pressure in the rabbit, as recorded by his method, is confirmed. 2. Van Leersum's conclusion concerning the influence of a liver diet on the blood pressure of the rabbit is not substantiated by his data, since the fluctuations of blood pressure he obtained do not surpass his own recorded figures for normal animals. 3. Fluctuations of systolic blood pressure beyond the "normal" range are not necessary for the production of experimental atherosclerosis of the aorta in rabbits. Inversely, egg yolk feeding experiments in rabbits in which atherosclerosis of varying degree, even extreme, is obtained, are not accompanied by an elevation of blood pressure outside the "normal" range. 4. The fluctuations of blood pressure observed during experimental atherosclerosis do not simulate the condition of essential hypertension in man.


2020 ◽  
Vol 62 (3) ◽  
pp. 159-165
Author(s):  
Wiesław J. Kochański ◽  
Maciej Kochański ◽  
Adrianna Frankowska

Aim: The aim of this study was to investigate the effect of pearl bath on basic parameters of the cardiovascular system in patients without hypertension Material and Methods: This study recruited 40 patients without hypertension (20 male and 20 female). All patients had their blood pressure and heart rate measured immediately before and during the procedure. Results: During the pearl bath HR increased by an average of 2.6 bpm (p=0,018355), and from the measurement before surgery by 5.5 bpm (p=0,000404). SBP decreased during the bath by 8.7 mmHg (p=0.000001), DBP by 4.8 mmHg (p=0,000727). SBP, DBP values for pre-treatment measurements decreased by 14.4 mmHg (p=0,000000) and 9.7 mmHg (p=0,000005), respectively. Conclusions: Pearl baths decreases blood pressure and increase pulse. The dynamics of changes in systolic blood pressure, diastolic blood pressure and heart rate do not differ significantly between male and female.


2020 ◽  
pp. 30-40
Author(s):  
M. G. Melnik

Purpose. To study the dynamics of blood pressure (BP) indicators under the influence of exogenously administered melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) with various manifestations of desynchronosis of circadian BP rhythms (arterial hypertension – AH, high normal blood pressure) to determine the scheme of their effective compensation. Material and methods. The study included 101 patients with desynchronosis of circadian rhythms of blood pressure – 52 patients with hypertension, constituting the first and second groups, and 49 individuals with high normal blood pressure, representing the third and fourth groups. Patients of the second and fourth groups received conservative therapy, patients of the first and third groups combined it with melatonin. All patients underwent measurements of office blood pressure, home monitoring of blood pressure (ABPM), electrocardiography, 24-hour blood pressure monitoring (ABPM). Results and discussion. In patients of the first and third groups, compared with the traditional treatment groups, by the end of the observation period, a significantly (p < 0.05) decrease in office systolic blood pressure (SBP) / diastolic blood pressure (DBP) was established: in the first group compared with the second – 1.11 / 1.13 times, in the third group compared to the fourth – 1.43 / 1.58 times; significantly more (p < 0.05) pronounced decrease in SBP / DBP during DMAD – by 1.08 / 1.17 and 1.58 / 1.62 times, respectively, Significantly (p < 0.05) more pronounced decrease in average daily, average daily and average nighttime SBP / DBP during ABPM – by 1.13 / 1.20, 1.11 / 1.20, 1.23 / 1.25 and 1.47 / 1.31, 1.42 / 1.19, 1.54 / 1.41 times, respectively; reliably (p < 0.05) more frequent registration of the dipper rhythm type SBP / DBP – 1.6 / 1.4 and 1.6 / 1.4 times, respectively. In addition, the dynamics of patients in the first and third groups showed a significant (p < 0.05) decrease in the mean daily and mean nighttime SBP / DBP variability (SBP in the first group by 27.3 and 41.3 %, respectively; DBP in the first group by 20.1 and 26.3 %, respectively; SBP in the third group by 13.5 and 25.2 %, respectively; DBP in the third group by 12.2 and 28.2 %, respectively). Conclusions. With various manifestations of desynchronosis of circadian rhythms of blood pressure (AH, high normal blood pressure), the prescription of melatonin (Melatonin-SZ, Severnaya Zvezda, Russia) at a dose of 3 mg per day 30–40 minutes before bedtime for a month against the background of non-drug therapy and antihypertensive drugs led to a significantly more effective decrease in blood pressure at its office measurement, DMAD, ABPM with an improvement in the circadian rhythm of blood pressure and normalization of blood pressure variability.


2003 ◽  
Vol 42 (149) ◽  
pp. 315-6
Author(s):  
Arijit Ghosh ◽  
T Pramanik

Higher exercise blood pressure represents low cardiorespiratory status of an individual and vice versa. Thechanges in systolic and diastolic blood pressure in response to rhythmic isotonic muscular exercise in sedentaryyoung normotensive Nepalese students were assessed. Normal blood pressure in standing posture in maleand female subjects are about 115 / 75 mm of Hg. and 106 / 71 mm of Hg. respectively. Just after the exercisesystolic blood pressure increases moderately in both the sexes, whereas diastolic blood pressure remainsunchanged in most of the females. Diastolic blood pressure is found to be decreased slightly in the males,just after exercise. The present study indicates the cardiorespiratory status of the Napalese medical studentsis within normal range.


2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Eun Sun Yu ◽  
Kwan Hong ◽  
Byung Chul Chun

Abstract Background The study aimed to estimate the incidence of and period of progression to stage 2 hypertension from normal blood pressure. Methods We selected a total of 21,172 normotensive individuals between 2003 and 2004 from the National Health Insurance Service-Health Screening and followed them up until 2015. The criteria for blood pressure were based on the American College of Cardiology/American Heart Association 2017 guideline (normal BP: SBP < 120 and DBP < 80 mmHg, elevated BP: SBP 120–129 and DBP < 80 mmHg, stage 1 hypertension: SBP 130–139 or DBP 80–89 mmHg, stage 2 hypertension: SBP ≥140 or DBP ≥ 90 mmHg). We classified the participants into four courses (Course A: normal BP → elevated BP → stage 1 hypertension→ stage 2 hypertension, Course B: normal BP → elevated BP → stage 2 hypertension, Course C: normal BP → stage 1 hypertension → stage 2 hypertension, Course D: normal BP → stage 2 hypertension) according to their progression from normal blood pressure to stage 2 hypertension. Results During the median 12.23 years of follow-up period, 52.8% (n= 11,168) and 23.6% (n=5004) of the participants had stage 1 and stage 2 hypertension, respectively. In particular, over 60 years old had a 2.8-fold higher incidence of stage 2 hypertension than 40–49 years old. After the follow-up period, 77.5% (n=3879) of participants with stage 2 hypertension were found to be course C (n= 2378) and D (n=1501). After the follow-up period, 77.5% (n=3879) of participants with stage 2 hypertension were found to be course C (n= 2378) and D (n=1501). The mean years of progression from normal blood pressure to stage 2 hypertension were 8.7±2.6 years (course A), 6.1±2.9 years (course B), 7.5±2.8 years (course C) and 3.2±2.0 years, respectively. Conclusions This study found that the incidence of hypertension is associated with the progression at each stage. We suggest that the strategies necessary to prevent progression to stage 2 hypertension need to be set differently for each target course.


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