scholarly journals Fatty Acid Binding Protein 4 (FABP4) Overexpression in Intratumoral Hepatic Stellate Cells within Hepatocellular Carcinoma with Metabolic Risk Factors

2018 ◽  
Vol 188 (5) ◽  
pp. 1213-1224 ◽  
Author(s):  
Norimichi Chiyonobu ◽  
Shu Shimada ◽  
Yoshimitsu Akiyama ◽  
Kaoru Mogushi ◽  
Michiko Itoh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Hepatic Stellate Cells ◽  
Fatty Acid Binding Protein ◽  
Stellate Cells ◽  
Metabolic Risk Factors ◽  
Metabolic Risk ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells

2018 ◽  
Vol 59 (3) ◽  
pp. 416-428 ◽  
Author(s):  
Jianguo Lin ◽  
Shizhong Zheng ◽  
Alan D. Attie ◽  
Mark P. Keller ◽  
David A. Bernlohr ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hepatic Stellate Cells ◽  
Protein Function ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Stellate Cells ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Perilipin 5

scholarly journals Relationship of urinary liver-type fatty acid-binding protein with cardiovascular risk factors in the Japanese population without chronic kidney disease: Sasayama study

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yoshimi Kubota ◽  
Aya Higashiyama ◽  
Mikio Marumo ◽  
Masami Konishi ◽  
Yoshiko Yamashita ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chronic Kidney Disease ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Proximal Tubular ◽  
The Relationship

Abstract Background Urinary liver-type fatty acid-binding protein (L-FABP) is a well-known marker of proximal tubular impairment. We evaluated the relationship between cardiovascular disease (CVD) risk factors and levels of L-FABP in a cross-sectional community-based study. Participants with normoalbuminuria and normal estimated glomerular filtration rate (eGFR), that is, non-chronic kidney disease (non-CKD), were enrolled in this study. To the best of our knowledge, this is the first study to focus on the association between CVD risk factors and a proximal tubular marker in the Japanese general population with normoalbuminuria and normal eGFR. Methods The present study is part of the Sasayama study. The participants included 1000 community residents (447 men and 553 women) aged 40–64 years without a history of CVD or renal dysfunction. Out of these participants 375 men and 477 women, defined as non-CKD, were included for further analysis. In each sex, the highest quintile group was considered to have high-normal L-FABP levels. A multiple logistic regression model was used to evaluate the relationship between risk factors for CVD and high-normal L-FABP levels in the non-CKD participants. We performed a similar analysis using the high-normal urinary albumin to creatinine ratio (UACR) as a dependent variable instead of L-FABP. Results Among the non-CKD participants, in the highest quintile group (Q5, top 20%), L-FABP was ≥2.17 μg/gCre in men and ≥ 2.83 μg/gCre in women. In women, the multivariate odds ratio was 3.62 (1.45–9.00) for high-normal L-FABP in the presence of diabetes mellitus (DM) compared with that in the group without DM. However, the relationship between DM and the UACR level was not significant. In men, DM was significantly associated with high-normal UACR. However, the relationship with L-FABP levels was not significant. Conclusions The presence of DM was more strongly related to high-normal L-FABP levels than to high-normal UACR in women even at the stage of normoalbuminuria and normal eGFR. Our results were also consistent with the findings of a previous study where women were more prone to nonalbuminuric renal impairment compared to men, although further studies are required to confirm the results.

scholarly journals Novel role for fatty acid binding protein-4 (FABP4) in hepatocellular carcinoma (HCC) progression

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S352-S353
Author(s):  
M. Patetta ◽  
Z. Stello ◽  
J. Lee ◽  
C. Jacobs ◽  
K. Gersin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level

2021 ◽  
Author(s):  
Masafumi Ohira ◽  
Hideki Yokoo ◽  
Koji Ogawa ◽  
Moto Fukai ◽  
Toshiya Kamiyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Tumor Marker ◽  
Cell Lines ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Tissue Expression ◽  
Serum Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Abstract Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significance in HCC progression. We compared the sFABP5 concentration in patients with HCC (HCC group) with that of patients with hepatitis without HCC (hepatitis group). Moreover, we measured the FABP5 expression levels in resected HCC tissues (tFABP5) and analyzed their relationship with sFABP5. We also performed cell-based assays using FABP5 knockout and overexpressing HCC cell lines to analyze the effect of extrinsic FABP5 on HCC cells. We showed that sFABP5 was not a useful tumor marker for HCC, as HCC and sFABP5 were not correlated. However, sFABP5 and tFABP5 significantly correlated with survival after surgery for HCC, while sFABP5 and tFABP5 were independent of each other. In cell-based assays, extrinsic FABP5 was taken up by HCC cell lines and positively affected cell survival under glucose-depleted conditions by complementing the endogenous FABP5 function. In conclusion, sFABP5 had a significant impact on HCC progression irrespective of tFABP5 by augmenting cell viability under glucose-depleted conditions. As tFABP5 and sFABP5 are important factors that are independent of each other in HCC progression, both of them should be considered independently in improving the prognosis of patients with HCC.

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