scholarly journals Altered epidermal fatty acid-binding protein expression in hepatocellular carcinoma predicts unfavorable outcomes

2018 ◽  
Vol Volume 10 ◽  
pp. 6275-6284 ◽  
Author(s):  
Jia-bin Lu ◽  
Shao-hang Cai ◽  
Ying-hua Pan ◽  
Jing-ping Yun
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Protein Expression ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Novel role for fatty acid binding protein-4 (FABP4) in hepatocellular carcinoma (HCC) progression

HPB ◽  
2018 ◽  
Vol 20 ◽  
pp. S352-S353
Author(s):  
M. Patetta ◽  
Z. Stello ◽  
J. Lee ◽  
C. Jacobs ◽  
K. Gersin ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Dietary fiber differentially alters cellular fatty acid‐binding protein expression in exfoliated colonocytes during tumor development

1998 ◽  
Vol 32 (2) ◽  
pp. 107-112 ◽  
Author(s):  
Robert S. Chapkin ◽  
Amy E. Clark ◽  
Laurie A. Davidson ◽  
Friedhelm Schroeder ◽  
Debra L. Zoran ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Expression ◽  
Dietary Fiber ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Tumor Development ◽  
Cellular Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Serum fatty acid-binding protein 5 is a significant factor in hepatocellular carcinoma progression independent of tissue expression level

2021 ◽  
Author(s):  
Masafumi Ohira ◽  
Hideki Yokoo ◽  
Koji Ogawa ◽  
Moto Fukai ◽  
Toshiya Kamiyama ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Fatty Acid ◽  
Tumor Marker ◽  
Cell Lines ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Tissue Expression ◽  
Serum Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Abstract Fatty acid-binding protein 5 (FABP5) is highly expressed in hepatocellular carcinoma (HCC) tissues and is related to HCC progression. In this study, we analyzed the potential of serum FABP5 (sFABP5) as a tumor marker in HCC and its clinical significance in HCC progression. We compared the sFABP5 concentration in patients with HCC (HCC group) with that of patients with hepatitis without HCC (hepatitis group). Moreover, we measured the FABP5 expression levels in resected HCC tissues (tFABP5) and analyzed their relationship with sFABP5. We also performed cell-based assays using FABP5 knockout and overexpressing HCC cell lines to analyze the effect of extrinsic FABP5 on HCC cells. We showed that sFABP5 was not a useful tumor marker for HCC, as HCC and sFABP5 were not correlated. However, sFABP5 and tFABP5 significantly correlated with survival after surgery for HCC, while sFABP5 and tFABP5 were independent of each other. In cell-based assays, extrinsic FABP5 was taken up by HCC cell lines and positively affected cell survival under glucose-depleted conditions by complementing the endogenous FABP5 function. In conclusion, sFABP5 had a significant impact on HCC progression irrespective of tFABP5 by augmenting cell viability under glucose-depleted conditions. As tFABP5 and sFABP5 are important factors that are independent of each other in HCC progression, both of them should be considered independently in improving the prognosis of patients with HCC.

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