scholarly journals Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury

2016 ◽  
Vol 186 (12) ◽  
pp. 3117-3130 ◽  
Author(s):  
Yanqing Zhang ◽  
Cheng Wang ◽  
Yunli Tian ◽  
Fengxiao Zhang ◽  
Wenjing Xu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic

Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

2017 ◽  
Vol 267 ◽  
pp. 1-10 ◽  
Author(s):  
Ning Zhang ◽  
Yan Hu ◽  
Chunchun Ding ◽  
Wenjing Zeng ◽  
Wen Shan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Salvianolic Acid B ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic ◽  
Salvianolic Acid

scholarly journals Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-αExpression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Jing-Hua Peng ◽  
Tuan Cui ◽  
Zhao-Lin Sun ◽  
Fu Huang ◽  
Liang Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protein Expression ◽  
Alcohol Intake ◽  
Alcoholic Liver Injury ◽  
Chronic Alcohol ◽  
Gamma Glutamyl Transpeptidase ◽  
Chronic Alcoholic ◽  
Necrosis Factor Alpha ◽  
Puerariae Radix

Kudzu (Pueraria lobata) is one of the earliest medicinal plants used to treat alcohol abuse in traditional Chinese medicine for more than a millennium. However, little is known about its effects on chronic alcoholic liver injury. Therefore, the present study observed the effects of puerariae radix extract (RPE) on chronic alcoholic liver injury as well as Kupffer cells (KCs) activation to release tumor necrosis factor alpha (TNF-α) induced by gut-derived endotoxin in rats and macrophage cell line. RPE was observed to alleviate the pathological changes and lipids deposition in liver tissues as well as the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic gamma-glutamyl transpeptidase (GGT) activity. Meanwhile, RPE inhibited KCs activation and subsequent hepatic TNF-αexpression and downregulated the protein expression of endotoxin receptors, lipopolysaccharide binding protein (LBP), CD14, Toll-like receptor (TLR) 2, and TLR4 in chronic alcohol intake rats. Furthermore, anin vitrostudy showed that RPE inhibited the expression of TNF-αand endotoxin receptors, CD14 and TLR4, induced by LPS in RAW264.7 cells. In summary, this study demonstrated that RPE mitigated liver damage and lipid deposition induced by chronic alcohol intake in rats, as well as TNF-αrelease, protein expression of endotoxin receptorsin vivoorin vitro.

Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats

2016 ◽  
Vol 60 (9) ◽  
pp. 1902-1911 ◽  
Author(s):  
Lili Gao ◽  
Wen Shan ◽  
Wenjing Zeng ◽  
Yan Hu ◽  
Guangzhi Wang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Carnosic Acid ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic

scholarly journals The standardized extract of Limonium tetragonum Alleviates chronic alcoholic liver injury in C57BL/6J Mice

2018 ◽  
Vol 14 (53) ◽  
pp. 58 ◽  
Author(s):  
MinHye Yang ◽  
EunJu Jeong ◽  
Na-Hyun Kim ◽  
Jeong-Doo Heo ◽  
Jung-Rae Rho
Keyword(s):  
Liver Injury ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic
Sign in / Sign up

Export Citation Format

Share Document