scholarly journals Study on the synergistic protective effect of Lycium barbarum L. polysaccharides and zinc sulfate on chronic alcoholic liver injury in rats

2019 ◽  
Vol 7 (11) ◽  
pp. 3435-3442 ◽  
Author(s):  
Yamei Yan ◽  
Wanqiang Wu ◽  
Lu Lu ◽  
Jie Ren ◽  
Jia Mi ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Zinc Sulfate ◽  
Alcoholic Liver Injury ◽  
Lycium Barbarum ◽  
Chronic Alcoholic

Involvement of Insulin Resistance in the Protective Effect of Metformin Against Alcoholic Liver Injury

2014 ◽  
Vol 38 (6) ◽  
pp. 1510-1519 ◽  
Author(s):  
ZhanTao Zhu ◽  
ZhiAn Jiang ◽  
JunYing Zhou ◽  
DongFang Zhou ◽  
Wei Wang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Injury ◽  
Protective Effect ◽  
Alcoholic Liver Injury

Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats

2017 ◽  
Vol 267 ◽  
pp. 1-10 ◽  
Author(s):  
Ning Zhang ◽  
Yan Hu ◽  
Chunchun Ding ◽  
Wenjing Zeng ◽  
Wen Shan ◽  
...  
Keyword(s):  
Liver Injury ◽  
Salvianolic Acid B ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic ◽  
Salvianolic Acid

scholarly journals Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice

Redox Report ◽  
2016 ◽  
Vol 22 (6) ◽  
pp. 338-345 ◽  
Author(s):  
Zhihui Jiang ◽  
Jian Wang ◽  
Huiting Xue ◽  
Meng Wang ◽  
Hai Jiang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protective Effect ◽  
Methanolic Extract ◽  
Alcoholic Liver Injury ◽  
Corni Fructus

scholarly journals Inhibition of Poly(ADP-Ribose) Polymerase-1 Protects Chronic Alcoholic Liver Injury

2016 ◽  
Vol 186 (12) ◽  
pp. 3117-3130 ◽  
Author(s):  
Yanqing Zhang ◽  
Cheng Wang ◽  
Yunli Tian ◽  
Fengxiao Zhang ◽  
Wenjing Xu ◽  
...  
Keyword(s):  
Liver Injury ◽  
Alcoholic Liver Injury ◽  
Chronic Alcoholic

scholarly journals Effects of Puerariae Radix Extract on Endotoxin Receptors and TNF-αExpression Induced by Gut-Derived Endotoxin in Chronic Alcoholic Liver Injury

2012 ◽  
Vol 2012 ◽  
pp. 1-12 ◽  
Author(s):  
Jing-Hua Peng ◽  
Tuan Cui ◽  
Zhao-Lin Sun ◽  
Fu Huang ◽  
Liang Chen ◽  
...  
Keyword(s):  
Liver Injury ◽  
Protein Expression ◽  
Alcohol Intake ◽  
Alcoholic Liver Injury ◽  
Chronic Alcohol ◽  
Gamma Glutamyl Transpeptidase ◽  
Chronic Alcoholic ◽  
Necrosis Factor Alpha ◽  
Puerariae Radix

Kudzu (Pueraria lobata) is one of the earliest medicinal plants used to treat alcohol abuse in traditional Chinese medicine for more than a millennium. However, little is known about its effects on chronic alcoholic liver injury. Therefore, the present study observed the effects of puerariae radix extract (RPE) on chronic alcoholic liver injury as well as Kupffer cells (KCs) activation to release tumor necrosis factor alpha (TNF-α) induced by gut-derived endotoxin in rats and macrophage cell line. RPE was observed to alleviate the pathological changes and lipids deposition in liver tissues as well as the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and hepatic gamma-glutamyl transpeptidase (GGT) activity. Meanwhile, RPE inhibited KCs activation and subsequent hepatic TNF-αexpression and downregulated the protein expression of endotoxin receptors, lipopolysaccharide binding protein (LBP), CD14, Toll-like receptor (TLR) 2, and TLR4 in chronic alcohol intake rats. Furthermore, anin vitrostudy showed that RPE inhibited the expression of TNF-αand endotoxin receptors, CD14 and TLR4, induced by LPS in RAW264.7 cells. In summary, this study demonstrated that RPE mitigated liver damage and lipid deposition induced by chronic alcohol intake in rats, as well as TNF-αrelease, protein expression of endotoxin receptorsin vivoorin vitro.

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