scholarly journals Saturated and Unsaturated Dietary Fats Differentially Modulate Ethanol-Induced Changes in Gut Microbiome and Metabolome in a Mouse Model of Alcoholic Liver Disease

2016 ◽  
Vol 186 (4) ◽  
pp. 765-776 ◽  
Author(s):  
Irina A. Kirpich ◽  
Joseph Petrosino ◽  
Nadim Ajami ◽  
Wenke Feng ◽  
Yuhua Wang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Gut Microbiome ◽  
Dietary Fats ◽  
Induced Changes

scholarly journals Camel milk modulates ethanol-induced changes in the gut microbiome and transcriptome in a mouse model of acute alcoholic liver disease

2020 ◽  
Vol 103 (5) ◽  
pp. 3937-3949
Author(s):  
Liang Ming ◽  
XiangYu Qiao ◽  
Li Yi ◽  
Dalai Siren ◽  
Jing He ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Gut Microbiome ◽  
Camel Milk ◽  
Induced Changes

Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in mouse model

2021 ◽  
Author(s):  
Mei Ji ◽  
Cheng Fang ◽  
Wei Jia ◽  
Hai Du ◽  
Yan Xu
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Volatile Compounds ◽  
Alcoholic Liver Disease ◽  
Alcoholic Beverages ◽  
Regulatory Effect ◽  
Main Risk Factor

Ethanol (EtOH) is the main risk factor for alcoholic liver disease. However, fermented alcoholic beverages contain not only ethanol but also various volatile compounds. Currently, effects of volatile compounds in...

scholarly journals NLRP6 Inflammasome Modulates Disease Progression in a Chronic-Plus-Binge Mouse Model of Alcoholic Liver Disease

Cells ◽  
2022 ◽  
Vol 11 (2) ◽  
pp. 182
Author(s):  
Rebecca Elena Mainz ◽  
Stefanie Albers ◽  
Madhuri Haque ◽  
Roland Sonntag ◽  
Nicole Simone Treichel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Immune Cell ◽  
Liver Steatosis ◽  
Neutrophil Infiltration ◽  
Ethanol Administration ◽  
Intestinal Homeostasis ◽  
Binge Ethanol

A considerable percentage of the population is affected by alcoholic liver disease (ALD). It is characterized by inflammatory signals from the liver and other organs, such as the intestine. The NLR family pyrin domain containing 6 (NLRP6) inflammasome complex is one of the most important inflammatory mediators. The aim of this study was to evaluate a novel mouse model for ALD characterized by 8-week chronic-plus-binge ethanol administration and to investigate the role of NLRP6 inflammasome for intestinal homeostasis and ALD progression using Nlrp6-/- mice. We showed that chronic-plus-binge ethanol administration triggers hepatic steatosis, injury, and neutrophil infiltration. Furthermore, we discovered significant changes of intestinal microbial communities, including increased relative abundances of bacteria within the phyla Bacteroidota and Campilobacterota, as well as reduced Firmicutes. In this ALD model, inhibiting NLRP6 signaling had no effect on liver steatosis or damage, but had a minor impact on intestinal homeostasis via affecting intestinal epithelium function and gut microbiota. Surprisingly, Nlrp6 loss resulted in significantly decreased hepatic immune cell infiltration. As a result, our novel mouse model encompasses several aspects of human ALD, such as intestinal dysbiosis. Interfering with NLRP6 inflammasome activity reduced hepatic immune cell recruitment, indicating a disease-aggravating role of NLRP6 during ALD.

scholarly journals Differential Metabolic Pathways and Metabolites in a C57BL/6J Mouse Model of Alcoholic Liver Disease

2020 ◽  
Vol 26 ◽  
Author(s):  
Tai Ma ◽  
Yue Li ◽  
Yun Zhu ◽  
Shuling Jiang ◽  
Chen Cheng ◽  
...  
Keyword(s):  
Liver Disease ◽  
Mouse Model ◽  
Alcoholic Liver Disease ◽  
Metabolic Pathways
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