scholarly journals Gut microbiome changes in Nonalcoholic fatty liver disease & alcoholic liver disease

2021 ◽  
Vol 6 ◽  
pp. 3-3
Author(s):  
Eric K. Kwong ◽  
Puneet Puri
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Alcoholic Liver Disease ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Su1553 – Oral and Gut Microbiome Diversity in Patients with Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Fibrosis

2019 ◽  
Vol 156 (6) ◽  
pp. S-1295-S-1296
Author(s):  
Rohini Mehta ◽  
James Paik ◽  
Sean C. Felix ◽  
Hussain Allawi ◽  
Ingrid Schneider ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Hepatic Fibrosis ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Microbiome Diversity

Distinguishing Nonalcoholic Fatty Liver Disease From Alcoholic Liver Disease: Is ANI Enough?

2007 ◽  
Vol 132 (5) ◽  
pp. 2076-2077
Author(s):  
Roberto J. Carvalho Filho ◽  
André N. Milani ◽  
Juliana P. Sampaio ◽  
Leonardo L. Schiavon ◽  
Janaína N. Schiavon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Alcoholic Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver

scholarly journals Drinking and Obesity: Alcoholic Liver Disease/Nonalcoholic Fatty Liver Disease Interactions

2020 ◽  
Vol 40 (02) ◽  
pp. 154-162 ◽  
Author(s):  
Fredrik Åberg ◽  
Martti Färkkilä
Keyword(s):  
Liver Disease ◽  
Alcohol Use ◽  
Fatty Liver ◽  
Binge Drinking ◽  
Nonalcoholic Fatty Liver Disease ◽  
Alcoholic Liver Disease ◽  
Fatty Liver Disease ◽  
Alcohol Intake ◽  
Interaction Effects ◽  
Nonalcoholic Fatty Liver

AbstractAlcohol and obesity are the main risk factors for alcoholic liver disease and nonalcoholic fatty liver disease (NAFLD), respectively, and they frequently coexist. There are considerable synergistic interaction effects between hazardous alcohol use and obesity-associated metabolic abnormalities in the development and progression of fatty liver disease. Intermittent binge-drinking has been shown to promote steatohepatitis from obesity-related steatosis, and binge-drinking is associated with progression to cirrhosis even when average alcohol intake is within the currently used criteria for a NAFLD diagnosis. Recent longitudinal studies in NAFLD have shown that light-to-moderate alcohol use is associated with fibrosis progression and incident clinical liver disease, suggesting that there is no liver-safe limit of alcohol intake in the presence of NAFLD; a J-shaped association between alcohol and all-cause mortality remains controversial. The interaction effects between alcohol and obesity make the present strict dichotomization of liver disease into alcoholic and NAFLD inappropriate, and require attention in future research, public health policy, individual counseling, and risk stratification.

scholarly journals Nonalcoholic fatty liver disease and the gut microbiome: Are bacteria responsible for fatty liver?

2019 ◽  
Vol 244 (6) ◽  
pp. 408-418 ◽  
Author(s):  
Tien S Dong ◽  
Jonathan P Jacobs
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Metabolic Disorders ◽  
Microbial Composition ◽  
Future Directions ◽  
Nonalcoholic Fatty Liver

Over the last several years, a growing body of literature has linked the gut microbiome to human health and diseases such as obesity, metabolic syndrome, and nonalcoholic fatty liver disease (NAFLD). This paper will review the current literature investigating the influence of diets associated with metabolic disorders on the microbiome and how those changes promote susceptibility to metabolic disorders. It will then focus in-depth on the role of the gut microbiome in NAFLD. The review will highlight associations of microbial composition and function with progression of NAFLD in patients and discuss potential mechanisms that link the gut microbiome to NAFLD. Finally, it will address limitations of existing studies along with future directions for microbiome research in NAFLD, including potential microbe-related treatments. Impact statement This invited minireview for the upcoming thematic issue on the microbiome addresses the role of the microbiome in nonalcoholic fatty liver disease (NAFLD). The incidence of NAFLD has increased greatly in recent years in parallel with the rise in obesity and is now believed to have a population prevalence of 20–40%. It is anticipated to soon become the primary cause of liver-related morbidity and mortality, and unfortunately, there are few treatment options. Therefore, there is a critical need for improved understanding of NAFLD pathophysiology to provide new avenues for therapeutic intervention. In this paper, we have reviewed evidence from human and animal model studies that have associated microbiome composition and microbial metabolites with development and progression of NAFLD. We have also discussed proposed mechanisms by which the microbiome could contribute to NAFLD pathogenesis and addressed future directions for this field.

scholarly journals Transient Elastography in Alcoholic Liver Disease and Nonalcoholic Fatty Liver Disease: A Systemic Review and Meta-Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Changzhou Cai ◽  
Xin Song ◽  
Xueyang Chen ◽  
Weihua Zhou ◽  
Qi Jin ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Sensitivity And Specificity ◽  
Alcoholic Liver Disease ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Meta Analysis ◽  
Systemic Review ◽  
Nonalcoholic Fatty Liver

Background and Aims. Alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) have become common chronic liver diseases. Recent evidence has shown the value of transient elastography (TE) in the context of ALD/NAFLD. The aim of this study is to investigate the accuracy of TE for diagnosing steatosis and fibrosis in ALD/NAFLD patients. Methods. We retrieved relevant English studies from the databases of PubMed, Embase, the Web of Science, and the Cochrane Library through March 31st 2019. We included studies regarding the diagnosis or staging of steatosis or fibrosis by using controlled attenuation parameter (CAP) or liver stiffness measurement (LSM) measured by TE in patients with ALD or NAFLD. The reference standard of all included studies was liver biopsy. A random-effects model was applied. Statistical analyses were performed using STATA. Results. A total of 62 articles were included and analyzed in our meta-analysis. In patients with ALD/NAFLD, the pooled results revealed that the sensitivity and specificity of CAP were 0.84, 0.83, and 0.78 and 0.83, 0.71, and 0.62 for steatosis grades ≥S1, ≥S2, and =S3, respectively. The sensitivity and specificity of LSM for identifying fibrosis grades ≥F1, ≥F2, ≥F3, and =F4 were 0.77, 0.77, 0.83, and 0.91 and 0.80, 0.82, 0.84, and 0.86, respectively. Conclusion. In patients with ALD/NAFLD, CAP was feasible for identifying and screening steatosis, and LSM was accurate for diagnosing fibrosis, especially severe fibrosis and cirrhosis.

scholarly journals Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease

2017 ◽  
Vol 25 (5) ◽  
pp. 1054-1062.e5 ◽  
Author(s):  
Rohit Loomba ◽  
Victor Seguritan ◽  
Weizhong Li ◽  
Tao Long ◽  
Niels Klitgord ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Gut Microbiome ◽  
Fatty Liver Disease ◽  
Advanced Fibrosis ◽  
Nonalcoholic Fatty Liver ◽  
Non Invasive
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