scholarly journals Myeloid A Disintegrin and Metalloproteinase Domain 10 Deficiency Modulates Atherosclerotic Plaque Composition by Shifting the Balance from Inflammation toward Fibrosis

2015 ◽  
Vol 185 (4) ◽  
pp. 1145-1155 ◽  
Author(s):  
Emiel P.C. van der Vorst ◽  
Mike Jeurissen ◽  
Ine M.J. Wolfs ◽  
Anke Keijbeck ◽  
Kosta Theodorou ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Plaque Composition ◽  
A Disintegrin And Metalloproteinase

scholarly journals Temporal and spatial changes in wall shear stress during atherosclerotic plaque progression in mice

2018 ◽  
Vol 5 (3) ◽  
pp. 171447 ◽  
Author(s):  
R. Xing ◽  
A. M. Moerman ◽  
Y. Ridwan ◽  
M. J. Daemen ◽  
A. F. W. van der Steen ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Mouse Model ◽  
Atherosclerotic Plaque ◽  
Proximal Part ◽  
Plaque Progression ◽  
Plaque Composition ◽  
Spatial Changes ◽  
Temporal And Spatial ◽  
Wall Shear

Wall shear stress (WSS) is involved in atherosclerotic plaque initiation, yet its role in plaque progression remains unclear. We aimed to study (i) the temporal and spatial changes in WSS over a growing plaque and (ii) the correlation between WSS and plaque composition, using animal-specific data in an atherosclerotic mouse model. Tapered casts were placed around the right common carotid arteries (RCCA) of ApoE −/− mice. At 5, 7 and 9 weeks after cast placement, RCCA geometry was reconstructed using contrast-enhanced micro-CT. Lumen narrowing was observed in all mice, indicating the progression of a lumen intruding plaque. Next, we determined the flow rate in the RCCA of each mouse using Doppler Ultrasound and computed WSS at all time points. Over time, as the plaque developed and further intruded into the lumen, absolute WSS significantly decreased. Finally at week 9, plaque composition was histologically characterized. The proximal part of the plaque was small and eccentric, exposed to relatively lower WSS. Close to the cast a larger and concentric plaque was present, exposed to relatively higher WSS. Lower WSS was significantly correlated to the accumulation of macrophages in the eccentric plaque. When pooling data of all animals, correlation between WSS and plaque composition was weak and no longer statistically significant. In conclusion, our data showed that in our mouse model absolute WSS strikingly decreased during disease progression, which was significantly correlated to plaque area and macrophage content. Besides, our study demonstrates the necessity to analyse individual animals and plaques when studying correlations between WSS and plaque composition.

Association of Statin Treatment With Progression of Coronary Atherosclerotic Plaque Composition

2021 ◽  
Author(s):  
Alexander R. van Rosendael ◽  
Inge J. van den Hoogen ◽  
Umberto Gianni ◽  
Xiaoyue Ma ◽  
Sara W. Tantawy ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Statin Treatment ◽  
Plaque Composition ◽  
Coronary Atherosclerotic Plaque

Quantitative assessment of stenosis severity and atherosclerotic plaque composition using 256-slice computed tomography

2010 ◽  
Vol 20 (8) ◽  
pp. 1841-1850 ◽  
Author(s):  
Grigorios Korosoglou ◽  
Dirk Mueller ◽  
Stephanie Lehrke ◽  
Henning Steen ◽  
Waldemar Hosch ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Atherosclerotic Plaque ◽  
Quantitative Assessment ◽  
Plaque Composition ◽  
Stenosis Severity

scholarly journals Noninvasive Imaging to Assess Atherosclerotic Plaque Composition and Disease Activity

2020 ◽  
Vol 13 (4) ◽  
pp. 1055-1068 ◽  
Author(s):  
Marwa Daghem ◽  
Rong Bing ◽  
Zahi A. Fayad ◽  
Marc R. Dweck
Keyword(s):  
Disease Activity ◽  
Atherosclerotic Plaque ◽  
Noninvasive Imaging ◽  
Plaque Composition

scholarly journals Intravascular Magnetic Resonance Imaging of Aortic Atherosclerotic Plaque Composition

1997 ◽  
Vol 17 (12) ◽  
pp. 3626-3632 ◽  
Author(s):  
Luis C. L. Correia ◽  
Ergin Atalar ◽  
Mark D. Kelemen ◽  
Ogan Ocali ◽  
Grover M. Hutchins ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Atherosclerotic Plaque ◽  
Resonance Imaging ◽  
Plaque Composition

Impact of adventitial neovascularisation on atherosclerotic plaque composition and vascular remodelling in a porcine model of coronary atherosclerosis

2010 ◽  
Vol 5 (8) ◽  
pp. 981-988 ◽  
Author(s):  
Carlos Alviar ◽  
Armando Tellez ◽  
David Wallace-Bradley ◽  
Gabriel Lopez-Berestein ◽  
Angela Sanguino ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Coronary Atherosclerosis ◽  
Porcine Model ◽  
Vascular Remodelling ◽  
Plaque Composition
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