Impact of adventitial neovascularisation on atherosclerotic plaque composition and vascular remodelling in a porcine model of coronary atherosclerosis

2010 ◽  
Vol 5 (8) ◽  
pp. 981-988 ◽  
Author(s):  
Carlos Alviar ◽  
Armando Tellez ◽  
David Wallace-Bradley ◽  
Gabriel Lopez-Berestein ◽  
Angela Sanguino ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Coronary Atherosclerosis ◽  
Porcine Model ◽  
Vascular Remodelling ◽  
Plaque Composition

scholarly journals Differential progression of coronary atherosclerosis according to plaque composition: a cluster analysis of PARADIGM registry data

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yeonyee E. Yoon ◽  
Lohendran Baskaran ◽  
Benjamin C. Lee ◽  
Mohit Kumar Pandey ◽  
Benjamin Goebel ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Atherosclerotic Plaque ◽  
Coronary Atherosclerosis ◽  
Multivariable Analysis ◽  
Necrotic Core ◽  
Patient Specific ◽  
Plaque Progression ◽  
Plaque Composition ◽  
Plaque Volume ◽  
Calcified Plaque

AbstractPatient-specific phenotyping of coronary atherosclerosis would facilitate personalized risk assessment and preventive treatment. We explored whether unsupervised cluster analysis can categorize patients with coronary atherosclerosis according to their plaque composition, and determined how these differing plaque composition profiles impact plaque progression. Patients with coronary atherosclerotic plaque (n = 947; median age, 62 years; 59% male) were enrolled from a prospective multi-national registry of consecutive patients who underwent serial coronary computed tomography angiography (median inter-scan duration, 3.3 years). K-means clustering applied to the percent volume of each plaque component and identified 4 clusters of patients with distinct plaque composition. Cluster 1 (n = 52), which comprised mainly fibro-fatty plaque with a significant necrotic core (median, 55.7% and 16.0% of the total plaque volume, respectively), showed the least total plaque volume (PV) progression (+ 23.3 mm3), with necrotic core and fibro-fatty PV regression (− 5.7 mm3 and − 5.6 mm3, respectively). Cluster 2 (n = 219), which contained largely fibro-fatty (39.2%) and fibrous plaque (46.8%), showed fibro-fatty PV regression (− 2.4 mm3). Cluster 3 (n = 376), which comprised mostly fibrous (62.7%) and calcified plaque (23.6%), showed increasingly prominent calcified PV progression (+ 21.4 mm3). Cluster 4 (n = 300), which comprised mostly calcified plaque (58.7%), demonstrated the greatest total PV increase (+ 50.7mm3), predominantly increasing in calcified PV (+ 35.9 mm3). Multivariable analysis showed higher risk for plaque progression in Clusters 3 and 4, and higher risk for adverse cardiac events in Clusters 2, 3, and 4 compared to that in Cluster 1. Unsupervised clustering algorithms may uniquely characterize patient phenotypes with varied atherosclerotic plaque profiles, yielding distinct patterns of progressive disease and outcome.

scholarly journals Temporal and spatial changes in wall shear stress during atherosclerotic plaque progression in mice

2018 ◽  
Vol 5 (3) ◽  
pp. 171447 ◽  
Author(s):  
R. Xing ◽  
A. M. Moerman ◽  
Y. Ridwan ◽  
M. J. Daemen ◽  
A. F. W. van der Steen ◽  
...  
Keyword(s):  
Shear Stress ◽  
Wall Shear Stress ◽  
Mouse Model ◽  
Atherosclerotic Plaque ◽  
Proximal Part ◽  
Plaque Progression ◽  
Plaque Composition ◽  
Spatial Changes ◽  
Temporal And Spatial ◽  
Wall Shear

Wall shear stress (WSS) is involved in atherosclerotic plaque initiation, yet its role in plaque progression remains unclear. We aimed to study (i) the temporal and spatial changes in WSS over a growing plaque and (ii) the correlation between WSS and plaque composition, using animal-specific data in an atherosclerotic mouse model. Tapered casts were placed around the right common carotid arteries (RCCA) of ApoE −/− mice. At 5, 7 and 9 weeks after cast placement, RCCA geometry was reconstructed using contrast-enhanced micro-CT. Lumen narrowing was observed in all mice, indicating the progression of a lumen intruding plaque. Next, we determined the flow rate in the RCCA of each mouse using Doppler Ultrasound and computed WSS at all time points. Over time, as the plaque developed and further intruded into the lumen, absolute WSS significantly decreased. Finally at week 9, plaque composition was histologically characterized. The proximal part of the plaque was small and eccentric, exposed to relatively lower WSS. Close to the cast a larger and concentric plaque was present, exposed to relatively higher WSS. Lower WSS was significantly correlated to the accumulation of macrophages in the eccentric plaque. When pooling data of all animals, correlation between WSS and plaque composition was weak and no longer statistically significant. In conclusion, our data showed that in our mouse model absolute WSS strikingly decreased during disease progression, which was significantly correlated to plaque area and macrophage content. Besides, our study demonstrates the necessity to analyse individual animals and plaques when studying correlations between WSS and plaque composition.

Association of Statin Treatment With Progression of Coronary Atherosclerotic Plaque Composition

2021 ◽  
Author(s):  
Alexander R. van Rosendael ◽  
Inge J. van den Hoogen ◽  
Umberto Gianni ◽  
Xiaoyue Ma ◽  
Sara W. Tantawy ◽  
...  
Keyword(s):  
Atherosclerotic Plaque ◽  
Statin Treatment ◽  
Plaque Composition ◽  
Coronary Atherosclerotic Plaque

Quantitative assessment of stenosis severity and atherosclerotic plaque composition using 256-slice computed tomography

2010 ◽  
Vol 20 (8) ◽  
pp. 1841-1850 ◽  
Author(s):  
Grigorios Korosoglou ◽  
Dirk Mueller ◽  
Stephanie Lehrke ◽  
Henning Steen ◽  
Waldemar Hosch ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Atherosclerotic Plaque ◽  
Quantitative Assessment ◽  
Plaque Composition ◽  
Stenosis Severity

scholarly journals Noninvasive Imaging to Assess Atherosclerotic Plaque Composition and Disease Activity

2020 ◽  
Vol 13 (4) ◽  
pp. 1055-1068 ◽  
Author(s):  
Marwa Daghem ◽  
Rong Bing ◽  
Zahi A. Fayad ◽  
Marc R. Dweck
Keyword(s):  
Disease Activity ◽  
Atherosclerotic Plaque ◽  
Noninvasive Imaging ◽  
Plaque Composition

scholarly journals Gender and the Extent of Coronary Atherosclerosis, Plaque Composition, and Clinical Outcomes in Acute Coronary Syndromes

2012 ◽  
Vol 5 (3) ◽  
pp. S62-S72 ◽  
Author(s):  
Alexandra J. Lansky ◽  
Vivian G. Ng ◽  
Akiko Maehara ◽  
Giora Weisz ◽  
Amir Lerman ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Acute Coronary Syndromes ◽  
Coronary Atherosclerosis ◽  
Plaque Composition ◽  
Coronary Syndromes

scholarly journals Intravascular Magnetic Resonance Imaging of Aortic Atherosclerotic Plaque Composition

1997 ◽  
Vol 17 (12) ◽  
pp. 3626-3632 ◽  
Author(s):  
Luis C. L. Correia ◽  
Ergin Atalar ◽  
Mark D. Kelemen ◽  
Ogan Ocali ◽  
Grover M. Hutchins ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Atherosclerotic Plaque ◽  
Resonance Imaging ◽  
Plaque Composition
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