scholarly journals Intranasal versus Intraperitoneal Delivery of Human Umbilical Cord Tissue–Derived Cultured Mesenchymal Stromal Cells in a Murine Model of Neonatal Lung Injury

2014 ◽  
Vol 184 (12) ◽  
pp. 3344-3358 ◽  
Author(s):  
Liansheng Liu ◽  
Quanfu Mao ◽  
Sharon Chu ◽  
Marwan Mounayar ◽  
Reza Abdi ◽  
...  
Keyword(s):  
Lung Injury ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Murine Model ◽  
Stromal Cells ◽  
Human Umbilical Cord ◽  
Neonatal Lung ◽  
Umbilical Cord Tissue ◽  
Neonatal Lung Injury

scholarly journals Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder

2020 ◽  
Vol 9 (10) ◽  
pp. 1137-1146 ◽  
Author(s):  
Jessica M. Sun ◽  
Geraldine Dawson ◽  
Lauren Franz ◽  
Jill Howard ◽  
Colleen McLaughlin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue

scholarly journals Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Eder Zucconi ◽  
Natassia Moreira Vieira ◽  
Carlos Roberto Bueno ◽  
Mariane Secco ◽  
Tatiana Jazedje ◽  
...  
Keyword(s):  
Animal Models ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Muscle Cells ◽  
Muscular Dystrophies ◽  
Human Umbilical Cord ◽  
Preclinical Studies ◽  
Cell Based Therapy ◽  
Umbilical Cord Tissue

Umbilical cord mesenchymal stromal cells (MSC) have been widely investigated for cell-based therapy studies as an alternative source to bone marrow transplantation. Umbilical cord tissue is a rich source of MSCs with potential to derivate at least muscle, cartilage, fat, and bone cellsin vitro. The possibility to replace the defective muscle cells using cell therapy is a promising approach for the treatment of progressive muscular dystrophies (PMDs), independently of the specific gene mutation. Therefore, preclinical studies in different models of muscular dystrophies are of utmost importance. The main objective of the present study is to evaluate if umbilical cord MSCs have the potential to reach and differentiate into muscle cellsin vivoin two animal models of PMDs. In order to address this question we injected (1) human umbilical cord tissue (hUCT) MSCs into the caudal vein ofSJLmice; (2) hUCT and canine umbilical cord vein (cUCV) MSCs intra-arterially in GRMD dogs. Our results here reported support the safety of the procedure and indicate that the injected cells could engraft in the host muscle in both animal models but could not differentiate into muscle cells. These observations may provide important information aiming future therapy for muscular dystrophies.

scholarly journals Targeting Neuroinflammation with Human Umbilical Cord Tissue‐Derived Mesenchymal Stromal Cells

2019 ◽  
Vol 8 (S1) ◽  
Author(s):  
Hyunjung Min ◽  
Arjun Saha ◽  
Li Xu ◽  
Melina Lillich ◽  
Roberta Parrott ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue

scholarly journals Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis

2019 ◽  
Vol 8 (6) ◽  
pp. 847 ◽  
Author(s):  
Mirjana Jerkic ◽  
Claire Masterson ◽  
Lindsay Ormesher ◽  
Stéphane Gagnon ◽  
Sakshi Goyal ◽  
...  
Keyword(s):  
Lung Injury ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Injury Severity ◽  
Therapeutic Potential ◽  
Human Macrophage ◽  
Human Umbilical Cord ◽  
Macrophage Function ◽  
E Coli

Enhancing the immunomodulatory effects of mesenchymal stromal cells (MSCs) may increase their effects in sepsis. We tested the potential for overexpression of Interleukin-10 (IL-10) in human umbilical cord (UC) MSCs to increase MSC efficacy in Escherichia coli (E. coli) pneumosepsis and to enhance human macrophage function. Pneumonia was induced in rats by intratracheal instillation of E. coli ((2.0–3.0) × 109 Colony forming units (CFU)/kg). One hour later, animals were randomized to receive (a) vehicle; (b) naïve UC-MSCs; or (c) IL-10 overexpressing UC-MSCs (1 × 107 cells/kg). Lung injury severity, cellular infiltration, and E. coli colony counts were assessed after 48 h. The effects and mechanisms of action of IL-10 UC-MSCs on macrophage function in septic rodents and in humans were subsequently assessed. Survival increased with IL-10 (9/11 (82%)) and naïve (11/12 (91%)) UC-MSCs compared to vehicle (9/15 (60%, p = 0.03). IL-10 UC-MSCs—but not naïve UC-MSCs—significantly decreased the alveolar arterial gradient (455 ± 93 and 520 ± 81, mmHg, respectively) compared to that of vehicle animals (544 ± 52, p = 0.02). Lung tissue bacterial counts were significantly increased in vehicle- and naïve-UC-MSC-treated animals but were not different from sham animals in those treated with IL-10 overexpressing UC-MSCs. IL-10 (but not naïve) UC-MSCs decreased alveolar neutrophils and increased alveolar macrophage percentages compared to vehicle. IL-10 UC-MSCs decreased structural lung injury compared to naïve UC-MSC or vehicle therapy. Alveolar macrophages from IL-10-UC-MSC-treated rats and from human volunteers demonstrated enhanced phagocytic capacity. This was mediated via increased macrophage hemeoxygenase-1, an effect blocked by prostaglandin E2 and lipoxygenase A4 blockade. IL-10 overexpression in UC-MSCs enhanced their effects in E. coli pneumosepsis and increased macrophage function. IL-10 UC-MSCs similarly enhanced human macrophage function, illustrating their therapeutic potential for infection-induced acute respiratory distress syndrome (ARDS).

Isolation of Multipotent Mesenchymal Stromal Cells from Cryopreserved Human Umbilical Cord Tissue

2016 ◽  
Vol 160 (4) ◽  
pp. 530-534 ◽  
Author(s):  
Yu. A. Romanov ◽  
E. E. Balashova ◽  
N. E. Volgina ◽  
N. V. Kabaeva ◽  
T. N. Dugina ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue
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