scholarly journals Targeting Neuroinflammation with Human Umbilical Cord Tissue‐Derived Mesenchymal Stromal Cells

2019 ◽  
Vol 8 (S1) ◽  
Author(s):  
Hyunjung Min ◽  
Arjun Saha ◽  
Li Xu ◽  
Melina Lillich ◽  
Roberta Parrott ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue

scholarly journals Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder

2020 ◽  
Vol 9 (10) ◽  
pp. 1137-1146 ◽  
Author(s):  
Jessica M. Sun ◽  
Geraldine Dawson ◽  
Lauren Franz ◽  
Jill Howard ◽  
Colleen McLaughlin ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue

scholarly journals Preclinical Studies with Umbilical Cord Mesenchymal Stromal Cells in Different Animal Models for Muscular Dystrophy

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Eder Zucconi ◽  
Natassia Moreira Vieira ◽  
Carlos Roberto Bueno ◽  
Mariane Secco ◽  
Tatiana Jazedje ◽  
...  
Keyword(s):  
Animal Models ◽  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Muscle Cells ◽  
Muscular Dystrophies ◽  
Human Umbilical Cord ◽  
Preclinical Studies ◽  
Cell Based Therapy ◽  
Umbilical Cord Tissue

Umbilical cord mesenchymal stromal cells (MSC) have been widely investigated for cell-based therapy studies as an alternative source to bone marrow transplantation. Umbilical cord tissue is a rich source of MSCs with potential to derivate at least muscle, cartilage, fat, and bone cellsin vitro. The possibility to replace the defective muscle cells using cell therapy is a promising approach for the treatment of progressive muscular dystrophies (PMDs), independently of the specific gene mutation. Therefore, preclinical studies in different models of muscular dystrophies are of utmost importance. The main objective of the present study is to evaluate if umbilical cord MSCs have the potential to reach and differentiate into muscle cellsin vivoin two animal models of PMDs. In order to address this question we injected (1) human umbilical cord tissue (hUCT) MSCs into the caudal vein ofSJLmice; (2) hUCT and canine umbilical cord vein (cUCV) MSCs intra-arterially in GRMD dogs. Our results here reported support the safety of the procedure and indicate that the injected cells could engraft in the host muscle in both animal models but could not differentiate into muscle cells. These observations may provide important information aiming future therapy for muscular dystrophies.

Isolation of Multipotent Mesenchymal Stromal Cells from Cryopreserved Human Umbilical Cord Tissue

2016 ◽  
Vol 160 (4) ◽  
pp. 530-534 ◽  
Author(s):  
Yu. A. Romanov ◽  
E. E. Balashova ◽  
N. E. Volgina ◽  
N. V. Kabaeva ◽  
T. N. Dugina ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue

Targeting neuroinflammation with human umbilical cord tissue-derived mesenchymal stromal cells

Cytotherapy ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. S104-S105
Author(s):  
A. Filiano ◽  
A. Saha ◽  
H. Min ◽  
L. Xu ◽  
M. Lillich ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Human Umbilical Cord ◽  
Umbilical Cord Tissue
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