scholarly journals IFN-γ Mediates the Antitumor Effects of Radiation Therapy in a Murine Colon Tumor

2013 ◽  
Vol 182 (6) ◽  
pp. 2345-2354 ◽  
Author(s):  
Scott A. Gerber ◽  
Abigail L. Sedlacek ◽  
Kyle R. Cron ◽  
Shawn P. Murphy ◽  
John G. Frelinger ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Colon Tumor ◽  
Antitumor Effects ◽  
Ifn Γ ◽  
Effects Of Radiation ◽  
Murine Colon

scholarly journals Microenvironment and Radiation Therapy

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Michio Yoshimura ◽  
Satoshi Itasaka ◽  
Hiroshi Harada ◽  
Masahiro Hiraoka
Keyword(s):  
Radiation Therapy ◽  
Tumor Microenvironment ◽  
Antiangiogenic Therapy ◽  
Hypoxia Inducible Factor ◽  
Tumor Hypoxia ◽  
Tumor Oxygenation ◽  
Therapeutic Effects ◽  
Antitumor Effects ◽  
Hypoxia Inducible Factor 1 ◽  
Effects Of Radiation

Dependency on tumor oxygenation is one of the major features of radiation therapy and this has led many radiation biologists and oncologists to focus on tumor hypoxia. The first approach to overcome tumor hypoxia was to improve tumor oxygenation by increasing oxygen delivery and a subsequent approach was the use of radiosensitizers in combination with radiation therapy. Clinical use of some of these approaches was promising, but they are not widely used due to several limitations. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that is activated by hypoxia and induces the expression of various genes related to the adaptation of cellular metabolism to hypoxia, invasion and metastasis of cancer cells and angiogenesis, and so forth. HIF-1 is a potent target to enhance the therapeutic effects of radiation therapy. Another approach is antiangiogenic therapy. The combination with radiation therapy is promising, but several factors including surrogate markers, timing and duration, and so forth have to be optimized before introducing it into clinics. In this review, we examined how the tumor microenvironment influences the effects of radiation and how we can enhance the antitumor effects of radiation therapy by modifying the tumor microenvironment.

Systemic Effects of Radiation Therapy-Induced Abscopal Responses in Patients with Advanced Lung Cancer

Oncology ◽  
2020 ◽  
Vol 99 (1) ◽  
pp. 1-14
Author(s):  
Mark A. D’Andrea ◽  
G. Kesava Reddy
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Molecular Mechanisms ◽  
Advanced Nsclc ◽  
Advanced Lung Cancer ◽  
Current Evidence ◽  
Abscopal Effect ◽  
Antitumor Effects ◽  
Effects Of Radiation ◽  
Abscopal Effects

<b><i>Background:</i></b> Out-of-field tumor regression effects of radiation therapy (abscopal response) have been sporadically observed in the past, but they have only recently gained significant importance due to the use of innovative high-precision radiation delivery devices for the treatment of various cancers including non-small cell lung cancer (NSCLC). In this study, we provide a detailed overview of the current state of knowledge and clinical experience of radiation therapy-induced abscopal effects in patients with advanced NSCLC. <b><i>Summary:</i></b> Peer-reviewed published clinical evidence on the abscopal effect of radiation therapy was collected using electronic databases such as MEDLINE via PubMed and Google Scholar. The clinical data on the abscopal effect of radiation therapy were reviewed and the outcomes have been summarized. Most studies describing the abscopal effects of radiation therapy in patients with advanced NSCLC have been in the form of either case reports or small cohort studies. Although the exact molecular mechanisms for the abscopal effect are yet to be established, current evidence indicates that tumor cell destruction induced by local radiation therapy releases tumor antigens, which stimulate the immune system of the host to activate the body’s immune effector cells systemically and trigger the regression of distant nonirradiated cancer cells. These off-target antitumor effects of radiation therapy provide an opportunity to explore the use of the radiation therapy in combination with novel immunotherapy agents to maximize treatment outcomes in patients with advanced NSCLC and other cancers. <b><i>Key Message:</i></b> The findings suggest that radiation therapy has the ability to induce abscopal effects with an increased potential to boost these effects when it is used in combination with immunotherapy for the treatment of patients with advanced NSCLC and other cancers. Clinical trials investigating radiation therapy-induced abscopal effects may lead to a dramatic change in its use especially when it is combined with immunotherapy for the treatment of patients with advanced NSCLC.

scholarly journals Effects of radiation therapy on growing long bones

1976 ◽  
Vol 127 (6) ◽  
pp. 935-939 ◽  
Author(s):  
AA De Smet ◽  
LR Kuhns ◽  
JV Fayos ◽  
JF Holt
Keyword(s):  
Radiation Therapy ◽  
Long Bones ◽  
Effects Of Radiation

scholarly journals Synergistic antitumor effects of celecoxib with 5-fluorouracil depend on IFN-γ

2007 ◽  
Vol 121 (4) ◽  
pp. 878-883 ◽  
Author(s):  
Takanobu Irie ◽  
Masahiko Tsujii ◽  
Shingo Tsuji ◽  
Toshiyuki Yoshio ◽  
Shuji Ishii ◽  
...  
Keyword(s):  
Antitumor Effects ◽  
Ifn Γ

P.134 Effects of radiation therapy on cytologicspecimens of oral cancer

2005 ◽  
Vol 1 (1) ◽  
pp. 187
Author(s):  
R.M. Valeri ◽  
K. Vahtsevanos ◽  
E. Aslanidou ◽  
A. Ntomouchtsis ◽  
Z. Teieioudis ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Oral Cancer ◽  
Effects Of Radiation

Risk of subsequent colorectal cancers after a solid tumor in childhood: Effects of radiation therapy and chemotherapy

2018 ◽  
Vol 66 (2) ◽  
pp. e27495 ◽  
Author(s):  
Rodrigue S. Allodji ◽  
Nadia Haddy ◽  
Giao Vu-Bezin ◽  
Agnès Dumas ◽  
Brice Fresneau ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Solid Tumor ◽  
Colorectal Cancers ◽  
Effects Of Radiation ◽  
Tumor In Childhood

scholarly journals LATE RADIATION TOXICITY AFTER RADICAL RADIOTHERAPY FOR GENITAL CANCER

2020 ◽  
Vol 25 ◽  
pp. 130-147
Author(s):  
O. Sukhina ◽  
◽  
K. Nemaltsova ◽  
O. Panov ◽  
◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Radiation Damage ◽  
Malignant Tumors ◽  
Practical Experience ◽  
Radiation Toxicity ◽  
Long Term Effects ◽  
Radiation Cystitis ◽  
Local Radiation ◽  
Effects Of Radiation ◽  
Female Genital

Radiation therapy for malignant tumors of the female genital area, even with the use of modern radiotherapy equipment and dosimetric planning, causes the development of local radiation changes. An approach involving methods of general and local exposure is used in their treatment. One of the most promising directions is the creation of optimal combinations of medicines (in the form of ointments, gels, aerosols, suppositories, etc.), which have a therapeutic effect on the inflammatory process. The article reflects the clinical course and stage of occurrence of late radiation reactions of the skin, vaginal/cervix mucosa, bladder, and intestines, as well as the features of their treatment. Literary data and own practical experience in the treatment of radiation complications are presented. When reviewing the topic under study, it could be concluded that the leading cause of the development of local radiation damage is the errors in the planning and implementation of radiation therapy, when high absorbed doses that exceed the tolerance of healthy tissues are used. Another reason for this is the poor accounting for dose distribution of ionizing radiation in tissues, the presence of concomitant diseases in patients, and the underestimation of the long-term effects of radiation. Key words: female genital organs, radiation damage, radiodermatitis, radioepitheliitis, radiation rectitis, radiation cystitis.

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