scholarly journals Paigen Diet–Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1–Dependent Manner

2011 ◽  
Vol 179 (4) ◽  
pp. 1693-1705 ◽  
Author(s):  
Allan Lawrie ◽  
Abdul G. Hameed ◽  
Janet Chamberlain ◽  
Nadine Arnold ◽  
Aneurin Kennerley ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Interleukin 1 ◽  
Dependent Manner ◽  
Severe Pulmonary Hypertension ◽  
Apolipoprotein E Knockout Mice ◽  
Paigen Diet

25 Paigen diet-fed Apolipoprotein E knock-out mice develop severe pulmonary hypertension in an interleukin-1 dependent manner

Heart ◽  
2011 ◽  
Vol 97 (20) ◽  
pp. e7-e7
Author(s):  
A. Lawrie ◽  
A. G. Hameed ◽  
J. Chamberlain ◽  
N. Arnold ◽  
D. C. Crossman ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Apolipoprotein E ◽  
Interleukin 1 ◽  
Dependent Manner ◽  
Severe Pulmonary Hypertension ◽  
Knock Out ◽  
Paigen Diet ◽  
Knock Out Mice

scholarly journals Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice

2005 ◽  
Vol 66 (3) ◽  
pp. 583-593 ◽  
Author(s):  
F MERHISOUSSI ◽  
B KWAK ◽  
D MAGNE ◽  
C CHADJICHRISTOS ◽  
M BERTI ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Vascular Inflammation ◽  
Interleukin 1 ◽  
Apolipoprotein E Knockout Mice

scholarly journals Trans-10, cis-12- and cis-9, trans-11-Conjugated Linoleic Acid Isomers Selectively Modify HDL-Apolipoprotein Composition in Apolipoprotein E Knockout Mice

2006 ◽  
Vol 136 (2) ◽  
pp. 353-359 ◽  
Author(s):  
José M. Arbonés-Mainar ◽  
María A. Navarro ◽  
Sergio Acín ◽  
Mario A. Guzmán ◽  
Carmen Arnal ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Apolipoprotein E ◽  
Conjugated Linoleic Acid ◽  
Knockout Mice ◽  
Apolipoprotein E Knockout Mice

scholarly journals Monocyte chemoattractant protein-1 involvement in the α-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice

2003 ◽  
Vol 90 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Maria C. G. Peluzio ◽  
Emir Miguel ◽  
Thaís C. Drumond ◽  
Giovana C. César ◽  
Helton C. Santiago ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Quantitative Polymerase Chain Reaction ◽  
Lesion Size ◽  
Tocopheryl Acetate ◽  
Aortic Lesion ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Apolipoprotein E Knockout Mice

We studied the effects of α-tocopheryl acetate supplementation on the development of fatty streaks and its ability to modulate the expression of monocyte chemoattractant protein (MCP)-1 in aortic lesions of apoliprotein E knockout mice. For this purpose, 16-week-old apolipoprotein E knockout mice received α-tocopherol supplemention ((800 mg)/kg diet) for 6 weeks. After this time, total and lipoprotein cholesterol in the serum, hepatic tocopherol, aortic lesion area and MCP-1 (protein and mRNA) expression were analysed. Our present results showed that the dietary supplementation with α-tocopherol did not reduce serum cholesterol nor change lipoprotein profile, but it reduced the area of the aortic lesion by 55%. The reduction in the lesion size was correlated with the reduced expression of MCP-1 mRNA and protein, as detected by real-time quantitative polymerase chain reaction and immunohistochemistry respectively. In conclusion, the results obtained here are relevant to the study of atherosclerosis, as they correlate the effectiveness of vitamin E supplementation in inhibiting the plaque formation with diminished expression of MCP-1 at the aortic lesion.

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