Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study

2017 ◽  
Vol 151 (1) ◽  
pp. 92-104 ◽  
Author(s):  
Ayşegül Güleç ◽  
Banu Çakırer Bakkalbaşı ◽  
Alev Cumbul ◽  
Ünal Uslu ◽  
Burçin Alev ◽  
...  
2020 ◽  
Vol 90 (3) ◽  
pp. 354-361 ◽  
Author(s):  
Ahmed El-Timamy ◽  
Fouad El Sharaby ◽  
Faten Eid ◽  
Amr El Dakroury ◽  
Yehya Mostafa ◽  
...  

ABSTRACT Objective To investigate the effect of local injection of platelet-rich plasma (PRP) on the rate of orthodontic tooth movement. Materials and Methods Sixteen female patients were randomly allocated in a split-mouth study design to receive PRP injections with CaCl2 activating solution on one side (intervention side) while the other side received CaCl2 injection only (control side). Canine retraction was performed on 0.017 × 0.025-inch stainless steel archwire applying 1.5 N retraction force. PRP and CaCl2 injections were done at 0, 3, and 6 weeks. The duration of the study was 4 months. Data were collected from digitized models. Assessment of pain accompanying the procedure was done using a visual analogue scale. Results The rate of canine retraction was faster on the intervention side in the first 2 months, with a statistically significant difference in the first month (P = .049). On the other hand, the rate was statistically significantly slower on the intervention side in the third month following cessation of PRP injections (P = .02). Pain increased following injections on both sides. Conclusions PRP showed a positive potential to accelerate the rate of tooth movement when injected in the first 2 months. Repeated injections of PRP to maintain a steady rate of accelerated tooth movement warrant further investigation.


2017 ◽  
Vol 48 (3) ◽  
pp. 199-208 ◽  
Author(s):  
Qihui Gu ◽  
Shuyu Guo ◽  
Dongyue Wang ◽  
Tingting Zhou ◽  
Lin Wang ◽  
...  

2016 ◽  
Vol 21 (2) ◽  
pp. 45-50 ◽  
Author(s):  
Mohammad Sadegh Ahmad Akhoundi ◽  
Rezvaneh Ghazanfari ◽  
Shahroo Etemad-Moghadam ◽  
Mojgan Alaeddini ◽  
Azam Khorshidian ◽  
...  

ABSTRACT Introduction: Osteoclasts and osteoblasts are responsible for regulating bone homeostasis during which the trace element zinc has been shown to exert a cumulative effect on bone mass by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption. Objective: The aim of the present study was to investigate the effects of zinc (Zn) on orthodontic tooth movement (OTM) in a rat model. Material and Methods: A total of 44 male Wistar rats were divided into four groups of 11 animals each and received 0, 1.5, 20 and 50 ppm Zn in distilled water for 60 days. In the last 21 days of the study, nickel-titanium closed coil springs were ligated between maxillary right incisors and first molars of all rats, and tooth movement was measured at the end of this period. Histological analysis of hematoxylin/eosin slides was performed to assess root resorption lacunae, osteoclast number and periodontal ligament (PDL) width. Results: Mean OTM was calculated as 51.8, 49.1, 35.5 and 45 µm in the 0, 1.5, 20 and 50 ppm zinc-receiving groups, respectively. There were no significant differences in neither OTM nor histological parameters among the study groups (p > 0.05). Conclusion: According to the results obtained in the current investigation, increase in supplementary zinc up to 50 ppm does not affect the rate of OTM neither bone and root resorption in rats.


2013 ◽  
Vol 16 (3) ◽  
pp. 161-168 ◽  
Author(s):  
L. Young ◽  
I. Binderman ◽  
A. Yaffe ◽  
L. Beni ◽  
A. D. Vardimon

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