scholarly journals Local delivery of nitric oxide: Targeted delivery of therapeutics to bone and connective tissues

2012 ◽  
Vol 64 (12) ◽  
pp. 1177-1188 ◽  
Author(s):  
Scott P. Nichols ◽  
Wesley L. Storm ◽  
Ahyeon Koh ◽  
Mark H. Schoenfisch
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Local Delivery ◽  
Connective Tissues

Encapsulation of VEGF165into magnetic PLGA nanocapsules for potential local delivery and bioactivity in human brain endothelial cells

2015 ◽  
Vol 3 (12) ◽  
pp. 2538-2544 ◽  
Author(s):  
E. Carenza ◽  
O. Jordan ◽  
P. Martínez-San Segundo ◽  
R. Jiřík ◽  
Z. Starčuk jr ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Endothelial Cells ◽  
Human Brain ◽  
Targeted Delivery ◽  
Drug Delivery Systems ◽  
Therapeutic Angiogenesis ◽  
Delivery Systems ◽  
Local Delivery ◽  
Brain Endothelial Cells ◽  
Angiogenic Proteins

New drug delivery systems based on biodegradable magnetic nanocapsules for targeted delivery of pro-angiogenic proteins, potentially useful in therapeutic angiogenesis, are reported.

scholarly journals Local infusion of the nitric oxide donor sin-1 after angioplasty: Effects on intimal hyperplasia in porcine coronary arteries

2003 ◽  
Vol 44 (4) ◽  
pp. 395-402
Author(s):  
J. Harnek ◽  
E. Zoucas ◽  
R. Sjuve ◽  
A. Arner ◽  
E. Ekblad ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Arteries ◽  
Intimal Hyperplasia ◽  
Percutaneous Transluminal Coronary Angioplasty ◽  
Local Delivery ◽  
Nitric Oxide Donor ◽  
Histological Evaluation ◽  
No Donor ◽  
Luminal Diameter ◽  
Transluminal Coronary Angioplasty

Purpose: To investigate the development of intimal hyperplasia in response to percutaneous transluminal coronary angioplasty (PTCA) followed by local delivery of the nitric oxide (NO) donor 3-morpholino-sydnonimine (SIN-1). Material and Methods: Overdilation PTCA was performed in coronary arteries in 20 healthy pigs. One of the dilated segments was additionally treated with local delivery of SIN-1 for 10 min. Segments distal to the treated part of the arteries served as controls. Arteries were radiographically depicted and analyzed after 1 and 8 weeks for actin, myosin and intermediate filaments (IF), nitric oxide synthetase (NOS) and histological evaluation. Results: Segments treated with PTCA+SIN-1 showed a significantly ( p = 0.03) larger luminal diameter compared with PTCA only treated segments. The luminal loss after SIN-1 was not significant compared with the diameter prior to treatment. Endothelial NOS content was significantly lower in the PTCA+SIN-1 group compared with the PTCA group after 1 ( p = 0.03) and 8 weeks ( p = 0.013). IF/actin ratio after 1 week was significantly increased in PTCA-treated segments compared with untreated controls ( p = 0.004), and compared with PTCA+SIN-1-treated segments ( p = 0.004). Conclusion: PTCA-induced intimal hyperplasia was potently inhibited by local delivery of the NO donor SIN-1. Momentary events at the time of injury play a significant role in the development of intimal hyperplasia and long-lasting down-regulation of the endothelial NOS expression after SIN-1 exposure is suggested. The IF/actin ratio can be useful as an early marker of intimal hyperplasia.

A multifunctional nanoplatform for lysosome targeted delivery of nitric oxide and photothermal therapy under 808 nm near-infrared light

2016 ◽  
Vol 4 (27) ◽  
pp. 4667-4674 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Min Guo ◽  
Lu An ◽  
Shi-Ping Yang ◽  
Qian-Ling Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

NIR light induced spatiotemporal delivery of NO to lysosome accompanied by hyperthermia was realized.

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

2018 ◽  
Vol 15 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Jingli Hou ◽  
Yiwa Pan ◽  
Dashuai Zhu ◽  
Yueyuan Fan ◽  
Guowei Feng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery

Targeted delivery of nitric oxide

Nature ◽  
2001 ◽  
Vol 409 (6820) ◽  
pp. 577-578 ◽  
Author(s):  
Steven S. Gross
Keyword(s):  
Nitric Oxide ◽  
Targeted Delivery

Tumor cell specific and lysosome-targeted delivery of nitric oxide for enhanced photodynamic therapy triggered by 808 nm near-infrared light

2016 ◽  
Vol 52 (1) ◽  
pp. 148-151 ◽  
Author(s):  
Hui-Jing Xiang ◽  
Qiao Deng ◽  
Lu An ◽  
Min Guo ◽  
Shi-Ping Yang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy ◽  
Tumor Cell ◽  
Cancer Cell ◽  
Targeted Delivery ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

A novel cancer cell lysosome-targetable multifunctional NO-delivery nanoplatform (Lyso-Ru-NO@FA@C-TiO2) (1) was developed.

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy

2017 ◽  
Vol 53 (22) ◽  
pp. 3253-3256 ◽  
Author(s):  
Min Guo ◽  
Hui-Jing Xiang ◽  
Yi Wang ◽  
Qian-Ling Zhang ◽  
Lu An ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Quantum Dots ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Graphene Quantum Dots ◽  
Antitumor Efficacy ◽  
Functionalized Graphene ◽  
Ruthenium Nitrosyl ◽  
Nir Light

Targeted delivery of NO accompanied by photothermal therapy shows efficient in vivo antitumor efficacy.

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