OncoGel (ReGel/paclitaxel) — Clinical applications for a novel paclitaxel delivery system

2009 ◽  
Vol 61 (10) ◽  
pp. 785-794 ◽  
Author(s):  
Nancy L. Elstad ◽  
Kirk D. Fowers
Keyword(s):  
Delivery System ◽  
Clinical Applications

scholarly journals Curcumin Protects Skin against UVB-Induced Cytotoxicity via the Keap1-Nrf2 Pathway: The Use of a Microemulsion Delivery System

2017 ◽  
Vol 2017 ◽  
pp. 1-17 ◽  
Author(s):  
Maya Ben Yehuda Greenwald ◽  
Marina Frušić-Zlotkin ◽  
Yoram Soroka ◽  
Shmuel Ben Sasson ◽  
Ronit Bitton ◽  
...  
Keyword(s):  
Delivery System ◽  
Chemical Structure ◽  
Clinical Applications ◽  
Antioxidant Protection ◽  
Nrf2 Pathway ◽  
Cytoprotective Enzymes ◽  
Poor Absorption ◽  
Unique Chemical ◽  
Induce Phase ◽  
Reducing Properties

Curcumin was found to be beneficial in treating several skin pathologies and diseases, providing antioxidant protection due to its reducing properties and its electrophilic properties (the ability to activate the Nrf2 pathway and induce phase II cytoprotective enzymes). Nevertheless, clinical applications of curcumin are being hampered by its insufficient solubility, chemical instability, and poor absorption, leading to low efficacy in preventing skin pathologies. These limitations can be overcome by using a nanotechnology-based delivery system. Here, we elucidated the possibility of using curcumin encapsulated in a microemulsion preserving its unique chemical structure. We also examined whether curcumin microemulsion would reduce UVB-induced toxicity in skin. A significant curcumin concentration was found in the human skin dermis following topical application of a curcumin microemulsion. Moreover, curcumin microemulsion enhanced the reduction of UV-induced cytotoxicity in epidermal cells, paving the way for other incorporated electrophiles in encapsulated form protecting skin against stress-related diseases.

scholarly journals Gene therapy

2021 ◽  
Vol 3 (3) ◽  
pp. 15-18
Author(s):  
A.G. Nerkar ◽  
G.S. Chakraborthy
Keyword(s):  
Gene Therapy ◽  
Immune System ◽  
Delivery System ◽  
Disease Gene ◽  
Genetic Material ◽  
Clinical Applications ◽  
Dna Transfer ◽  
Introduction History ◽  
Specific Disease

Gene therapy is used to correct defective genes in order to cure a disease or help your body better fight disease. Gene therapy is the introduction, removal or change in genetic material specifically DNA or RNA into the cells of a patient to treat a specific disease. Disease is caused to mutation. Genes influence all from the color of our hair to immune system, but genes are not built correctly. Targets of the gene therapy causing diseases. Gene therapy uses section of DNACurrently gene therapy is being tested only for disease that have no. other cures. Interest area of this review covers introduction, history, DNA transfer, Types of gene therapy, working of therapy, techniques, Delivery system, strategies, technique challenges, risks, gene introduction site and clinical applications of gene therapy.

A cancer-targeted drug delivery system developed with gold nanoparticle mediated DNA–doxorubicin conjugates

RSC Advances ◽  
2014 ◽  
Vol 4 (66) ◽  
pp. 34830-34835 ◽  
Author(s):  
Yu Qing Du ◽  
Xiao Xi Yang ◽  
Wen Long Li ◽  
Jian Wang ◽  
Cheng Zhi Huang
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticle ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Clinical Applications ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

A targeted drug delivery system based on AuNPs and DNA was developed to treat neuroblastoma cancer. This system exhibits excellent specificity in delivering and releasing doxorubicin, and has great prospects in clinical applications.

Specimen Preparation for Clinical Applications of X-Ray Microanalysis

1990 ◽  
Vol 48 (2) ◽  
pp. 328-329
Author(s):  
J.D. Shelburne ◽  
G.M. Roomans
Keyword(s):  
Carbon Coating ◽  
Clinical Applications ◽  
Point Of View ◽  
Practical Significance ◽  
Sweat Test ◽  
Specimen Preparation ◽  
Tissue Preparation ◽  
X Ray ◽  
Gallbladder Stones ◽  
Clinical Problems

Proper preparative procedures are a prerequisite for the validity of the results of x-ray microanalysis of biological tissue. Clinical applications of x-ray microanalysis are often concerned with diagnostic problems and the results may have profound practical significance for the patient. From this point of view it is especially important that specimen preparation for clinical applications is carried out correctly.Some clinical problems require very little tissue preparation. Hair, nails, and kidney and gallbladder stones may be examined and analyzed after carbon coating. High levels of zinc or copper in hair may be indicative of dermatological or systemic diseases. Nail clippings may be analyzed (as an alternative to the more conventional sweat test) to confirm a diagnosis of cystic fibrosis. X-ray microanalysis in combination with scanning electron microscopy has been shown to be the most reliable method for the identification of the components of kidney or gallbladder stones.A quantitatively very important clinical application of x-ray microanalysis is the identification and quantification of asbestos and other exogenous particles in lung.

Reduction of Potassium in Kidney Proximal Tubules to Aid in Electron Probe X-Ray Microanalysis of Calcium

1985 ◽  
Vol 43 ◽  
pp. 474-475
Author(s):  
A. LeFurgey ◽  
P. Ingram ◽  
L.J. Mandel
Keyword(s):  
Smooth Muscle ◽  
Proximal Tubule ◽  
Electron Probe ◽  
Clinical Applications ◽  
Proximal Tubules ◽  
Rabbit Kidney ◽  
Target Cells ◽  
X Ray ◽  
Freeze Dried

For quantitative determination of subcellular Ca distribution by electron probe x-ray microanalysis, decreasing (and/or eliminating) the K content of the cell maximizes the ability to accurately separate the overlapping K Kß and Ca Kα peaks in the x-ray spectra. For example, rubidium has been effectively substituted for potassium in smooth muscle cells, thus giving an improvement in calcium measurements. Ouabain, a cardiac glycoside widely used in experimental and clinical applications, inhibits Na-K ATPase at the cell membrane and thus alters the cytoplasmic ion (Na,K) content of target cells. In epithelial cells primarily involved in active transport, such as the proximal tubule of the rabbit kidney, ouabain rapidly (t1/2= 2 mins) causes a decrease2 in intracellular K, but does not change intracellular total or free Ca for up to 30 mins. In the present study we have taken advantage of this effect of ouabain to determine the mitochondrial and cytoplasmic Ca content in freeze-dried cryosections of kidney proximal tubule by electron probe x-ray microanalysis.

Simple teaching aid with clinical applications

1976 ◽  
Vol 40 (2) ◽  
pp. 106-106
Author(s):  
DL Torney ◽  
HD Espinosa
Keyword(s):  
Clinical Applications ◽  
Teaching Aid
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