Similar expression pattern of NHERF1 and EZRIN in papillary but not in solid areas of human serous ovarian carcinomas

2016 ◽  
Vol 118 (8) ◽  
pp. 797-805 ◽  
Author(s):  
Brenda Demacopulo ◽  
Baltazar Eduardo Lema ◽  
Rómulo Luis Cabrini ◽  
Erica Lorena Kreimann
Keyword(s):  
Expression Pattern ◽  
Ovarian Carcinomas ◽  
Similar Expression ◽  
Similar Expression Pattern

The Similar Expression Pattern of MHC Class I Molecules in Human and Mouse Cerebellar Cortex

2013 ◽  
Vol 39 (1) ◽  
pp. 180-186 ◽  
Author(s):  
Dan Lv ◽  
Qian Shi ◽  
Jiane Liu ◽  
Aifeng Zhang ◽  
Fengqin Miao ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Mhc Class I ◽  
Cerebellar Cortex ◽  
Class I ◽  
Similar Expression ◽  
Similar Expression Pattern ◽  
Human And Mouse ◽  
Mhc Class I Molecules

scholarly journals Analysis of maxillopedia Expression Pattern and Larval Cuticular Phenotype in Wild-Type and Mutant Tribolium

Genetics ◽  
2000 ◽  
Vol 155 (2) ◽  
pp. 721-731 ◽  
Author(s):  
Teresa D Shippy ◽  
Jianhua Guo ◽  
Susan J Brown ◽  
Richard W Beeman ◽  
Robin E Denell
Keyword(s):  
Rna Interference ◽  
Expression Pattern ◽  
Tribolium Castaneum ◽  
Expression Patterns ◽  
Ectopic Expression ◽  
Homeotic Gene ◽  
Wild Type ◽  
Double Stranded Rna ◽  
Similar Expression ◽  
Mutant Phenotypes

Abstract The Tribolium castaneum homeotic gene maxillopedia (mxp) is the ortholog of Drosophila proboscipedia (pb). Here we describe and classify available mxp alleles. Larvae lacking all mxp function die soon after hatching, exhibiting strong transformations of maxillary and labial palps to legs. Hypomorphic mxp alleles produce less severe transformations to leg. RNA interference with maxillopedia double-stranded RNA results in phenocopies of mxp mutant phenotypes ranging from partial to complete transformations. A number of gain-of-function (GOF) mxp alleles have been isolated based on transformations of adult antennae and/or legs toward palps. Finally, we have characterized the mxp expression pattern in wild-type and mutant embryos. In normal embryos, mxp is expressed in the maxillary and labial segments, whereas ectopic expression is observed in some GOF variants. Although mxp and Pb display very similar expression patterns, pb null embryos develop normally. The mxp mutant larval phenotype in Tribolium is consistent with the hypothesis that an ancestral pb-like gene had an embryonic function that was lost in the lineage leading to Drosophila.

scholarly journals Global Expression Analysis of the Yeast Lachancea (Saccharomyces) kluyveri Reveals NewURCGenes Involved in Pyrimidine Catabolism

2013 ◽  
Vol 13 (1) ◽  
pp. 31-42 ◽  
Author(s):  
Anna Andersson Rasmussen ◽  
Dineshkumar Kandasamy ◽  
Halfdan Beck ◽  
Seth D. Crosby ◽  
Olof Björnberg ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Catabolite Repression ◽  
Nitrogen Sources ◽  
Global Changes ◽  
Nitrogen Catabolite Repression ◽  
Content Type ◽  
Double Deletion ◽  
Pyrimidine Catabolism ◽  
Saccharomyces Kluyveri ◽  
Similar Expression Pattern

ABSTRACTPyrimidines are important nucleic acid precursors which are constantly synthesized, degraded, and rebuilt in the cell. Four degradation pathways, two of which are found in eukaryotes, have been described. One of them, theURCpathway, has been initially discovered in our laboratory in the yeastLachancea kluyveri. Here, we present the global changes in gene expression inL. kluyveriin response to different nitrogen sources, including uracil, uridine, dihydrouracil, and ammonia. The expression pattern of the knownURCgenes,URC1-6, helped to identify nine putative novelURCgenes with a similar expression pattern. The microarray analysis provided evidence that both theURCandPYDgenes are under nitrogen catabolite repression inL. kluyveriand are induced by uracil or dihydrouracil, respectively. We determined the function ofURC8, which was found to catalyze the reduction of malonate semialdehyde to 3-hydroxypropionate, the final degradation product of the pathway. The other eight genes studied were all putative permeases. Our analysis of double deletion strains showed that theL. kluyveriFui1p protein transported uridine, just like its homolog inSaccharomyces cerevisiae, but we demonstrated that is was not the only uridine transporter inL. kluyveri. We also showed that theL. kluyverihomologs ofDUR3andFUR4do not have the same function that they have inS. cerevisiae, where they transport urea and uracil, respectively. InL. kluyveri, both of these deletion strains grew normally on uracil and urea.

Overexpression and diffuse expression pattern of IQGAP1 at invasion fronts are independent prognostic parameters in ovarian carcinomas

2006 ◽  
Vol 243 (1) ◽  
pp. 120-127 ◽  
Author(s):  
Peixin Dong ◽  
Kazuki Nabeshima ◽  
Naoko Nishimura ◽  
Takehito Kawakami ◽  
Toru Hachisuga ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Prognostic Parameters ◽  
Ovarian Carcinomas ◽  
Invasion Fronts

scholarly journals Cytoplasmic Localization and Evolutionary Conservation of MEI-218, a Protein Required for Meiotic Crossing-over inDrosophila

2002 ◽  
Vol 13 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Elizabeth A. Manheim ◽  
Janet K. Jang ◽  
Danielle Dominic ◽  
Kim S. McKim
Keyword(s):  
Expression Pattern ◽  
Meiotic Recombination ◽  
Meiotic Prophase ◽  
Intracellular Localization ◽  
Crossing Over ◽  
Cytoplasmic Localization ◽  
Direct Role ◽  
Similar Expression Pattern ◽  
Oocyte Differentiation

During Drosophila oogenesis, the oocyte is formed within a 16-cell cyst immediately after four incomplete cell divisions. One of the primary events in oocyte development is meiotic recombination. Here, we report the intracellular localization of the MEI-218 protein that is specifically required for meiotic crossing-over. To understand the role of mei-218 in meiosis and to study the regulation of genes required for meiotic recombination, we characterized the expression pattern of its RNA and protein. Furthermore, we cloned and sequenced mei-218from two other Drosophila species. Themei-218 RNA and protein have a similar expression pattern, appearing first in early meiotic prophase and then rapidly disappearing as prophase is completed. This pattern corresponds to a specific appearance of the mei-218 gene product in the region of the ovary where meiotic prophase occurs. Althoughmei-218 is required for 95% of all crossovers, the protein is found exclusively in the cytoplasm. Based on these results, we suggest that mei-218 does not have a direct role in recombination but rather regulates other factors required for the production of crossovers. We propose that mei-218 is a molecular link between oocyte differentiation and meiosis.

scholarly journals Chicken Pleiotrophin: Regulation of Tissue Specific Expression by Estrogen in the Oviduct and Distinct Expression Pattern in the Ovarian Carcinomas

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34215 ◽  
Author(s):  
Jin-Young Lee ◽  
Wooyoung Jeong ◽  
Whasun Lim ◽  
Jinyoung Kim ◽  
Fuller W. Bazer ◽  
...  
Keyword(s):  
Expression Pattern ◽  
Ovarian Carcinomas ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression
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