Expression of integrin α5 and integrin β4 and their extracellular ligands fibronectin and laminin in human decidua during early pregnancy and its sex steroid-mediated regulation

2005 ◽  
Vol 107 (3) ◽  
pp. 173-185 ◽  
Author(s):  
Umit A. Kayisli ◽  
Emin T. Korgun ◽  
Gokhan Akkoyunlu ◽  
Aydin Arici ◽  
Ramazan Demir
Keyword(s):  
Early Pregnancy ◽  
Sex Steroid ◽  
Integrin Β4 ◽  
Integrin Α5 ◽  
Human Decidua

The effects of the antiprogestin mifepristone, in vivo, and progesterone in vitro on prolactin production by the human decidua in early pregnancy

1990 ◽  
Vol 5 (5) ◽  
pp. 627-631 ◽  
Author(s):  
Wen Xuan Wu ◽  
Anna Glasier ◽  
Jane Norman ◽  
R.W. Kelly ◽  
D.T. Baird ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Human Decidua

scholarly journals Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires

2019 ◽  
Vol 20 (3) ◽  
pp. 687 ◽  
Author(s):  
Antonia Terzieva ◽  
Violeta Dimitrova ◽  
Lyubomir Djerov ◽  
Petya Dimitrova ◽  
Silvina Zapryanova ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Responses ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Γδ T Cells ◽  
Γδ T Cell ◽  
Maternal Immune System ◽  
Human Decidua ◽  
Maternal Fetal Interface

Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of harmful responses towards the fetus and ability to fight infections. TCR γδ cells have been implicated in the responses in infectious diseases, in the regulation of immune responses, and in tissue homeostasis and repair. The variety of functions makes γδ T cells a particularly interesting population during pregnancy. In this study, we investigated the proportion, phenotype and TCR γ and δ repertoires of γδ T cells at the maternal–fetal interface and in the blood of pregnant women using FACS, immunohistochemistry and spectratyping. We found an enrichment of activated and terminally differentiated pro-inflammatory γδ T-cell effectors with specific location in the human decidua during early pregnancy, while no significant changes in their counterparts in the blood of pregnant women were observed. Our spectratyping data revealed polyclonal CDR3 repertoires of the δ1, δ2 and δ3 chains and γ2, γ3, γ4 and γ5 chains and oligoclonal and highly restricted CDR3γ9 repertoire of γδ T cells in the decidua and blood of pregnant women. Early pregnancy induces recruitment of differentiated pro-inflammatory γδ T-cell effectors with diverse TCR repertoires at the maternal–fetal interface.

Tissue‐resident CD8 + T memory cells with unique properties are present in human decidua during early pregnancy

2020 ◽  
Vol 84 (1) ◽  
Author(s):  
Xixi Huang ◽  
Lu Liu ◽  
Chunfang Xu ◽  
Xiandong Peng ◽  
Dajin Li ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Memory Cells ◽  
Human Decidua

scholarly journals Early Prenatal Phthalate Exposure, Sex Steroid Hormones, and Birth Outcomes

2017 ◽  
Vol 102 (6) ◽  
pp. 1870-1878 ◽  
Author(s):  
Sheela Sathyanarayana ◽  
Samantha Butts ◽  
Christina Wang ◽  
Emily Barrett ◽  
Ruby Nguyen ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Inverse Relationship ◽  
Steroid Hormone ◽  
Sex Steroid ◽  
Lower Prevalence ◽  
Sex Steroid Hormone ◽  
Phthalate Exposure ◽  
Ethyl Hexyl ◽  
Phthalate Metabolite ◽  
Male Genital

Abstract Context: Adequate sex steroid hormone concentrations are essential for normal fetal genital development in early pregnancy. Our previous study demonstrated an inverse relationship between third-trimester di-2-ethyl hexyl phthalate exposure and total testosterone (TT) concentrations. Here, we examine early-pregnancy phthalates, sex steroid hormone concentrations, and newborn reproductive outcomes. Design: We examined associations between urinary phthalate metabolite concentrations in early pregnancy and serum free testosterone (FT), TT, estrone (E1), and estradiol (E2) in 591 woman/infant dyads in The Infant Development and Environment Study; we also examined relationships between hormones and newborn genital outcomes using multiple regression models with covariate adjustment. Results: E1 and E2 concentrations were 15% to 30% higher in relation to 1-unit increases in log monoisobutyl phthalate (MiBP), mono-2-ethyl hexyl phthalate, and mono-2-ethyl-5-oxy-hexyl phthalate concentrations, and E2 was 15% higher in relation to increased log monobenzyl phthalate (MBzP). FT concentrations were 12% lower in relation to 1-unit increases in log mono(carboxynonyl) phthalate (MCNP) and mono-2-ethyl-5-carboxypentyl phthalate concentrations. Higher maternal FT was associated with a 25% lower prevalence of having a male genital abnormality at birth. Conclusions: The positive relationships between MiBP, MBzP, and DEHP metabolites and E1/E2 are unique and suggest a positive estrogenic effect in early pregnancy. The inverse relationship between MCNP and DEHP metabolites and serum FT supports previous work examining phthalate/testosterone relationships later in pregnancy. Higher FT in relation to a 25% lower prevalence of male genital abnormalities confirms the importance of testosterone in early fetal development.

Immunohistochemical localization of progesterone receptor in human decidua of early pregnancy

1992 ◽  
Vol 7 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Jie-Dong Wang ◽  
Yao Fu ◽  
Wen-Liang Shi ◽  
Peng-Di Zhu ◽  
Jie Cheng ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Early Pregnancy ◽  
Immunohistochemical Localization ◽  
Human Decidua

Immunomorphologic Studies of Human Decidua - Associated Lymphoid Cells in Normal Early Pregnancy

1995 ◽  
pp. 367-371 ◽  
Author(s):  
Lucia Mincheva-Nilsson ◽  
Vladimir Baranov ◽  
Moorix Mo-Wai Yeung ◽  
Sten Hammarstrom ◽  
Marie-Louise Hammarstrom
Keyword(s):  
Early Pregnancy ◽  
Lymphoid Cells ◽  
Human Decidua

scholarly journals Uterus and endometrium: Sex steroid regulation of leukocyte traffic in human decidua

1996 ◽  
Vol 11 (10) ◽  
pp. 2257-2262 ◽  
Author(s):  
H.O.D. Critchley ◽  
R.W. Kelly ◽  
R.G. Lea ◽  
T.A. Drudy ◽  
R.L. Jones ◽  
...  
Keyword(s):  
Sex Steroid ◽  
Steroid Regulation ◽  
Human Decidua

Side population cells in the human decidua of early pregnancy exhibit stem/progenitor cell-like characteristics

2010 ◽  
Vol 21 (6) ◽  
pp. 783-793 ◽  
Author(s):  
Chun Guo ◽  
Huili Zhu ◽  
Wei Huang ◽  
Shengfu Li ◽  
Wenwen Qu ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Progenitor Cell ◽  
Side Population ◽  
Side Population Cells ◽  
Human Decidua

Digit ratio, a proposed marker of the prenatal hormone environment, is not associated with prenatal sex steroids, anogenital distance, or gender-typed play behavior in preschool age children

2020 ◽  
pp. 1-10
Author(s):  
Emily Barrett ◽  
Sally W. Thurston ◽  
Donald Harrington ◽  
Nicole R. Bush ◽  
Sheela Sathyanarayana ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
First Trimester ◽  
Preschool Age ◽  
Play Behavior ◽  
Digit Ratio ◽  
Sex Steroid ◽  
Linear Regression Models ◽  
Anogenital Distance ◽  
Sex Steroid Hormone ◽  
Prenatal Hormones

Abstract Prenatal hormones have been proposed as key factors impacting child development as well as long-term health and disease. Digit ratio (the ratio of the lengths of the second to fourth digits; 2D:4D) has been proposed as a sexually dimorphic, noninvasive marker of prenatal androgen exposure that can be reliably measured in children and adults. To date, few longitudinal pregnancy cohort studies have examined childhood digit ratio in relation to other relevant measures including prenatal hormones and androgen-sensitive outcomes. To augment the current literature on this topic, we measured right-hand digit ratio in 4-year-old children participating in The Infant Development and the Environment Study, a multicenter longitudinal cohort study that has been following mother–child dyads since the first trimester of pregnancy (n = 321). We assessed sex differences in digit ratio and fit multivariable linear regression models to examine digit ratio in relation to: (1) child sex; (2) maternal sex steroid hormone concentrations in early pregnancy; (3) newborn anogenital distance, another proposed measure of sensitivity to prenatal androgens; and (4) gender-typical play behavior as measured by the Preschool Activities Inventory (PSAI) at age 4. We observed no sex difference in digit ratio; the mean 2D:4D was 0.97 ± 0.05 mm in both sexes. Furthermore, digit ratio was not associated with maternal sex steroid concentrations in early pregnancy, anogenital distance in either sex, or PSAI scores in either sex in covariate-adjusted models. In conclusion, we observed no evidence that early childhood digit ratio was associated with child sex or hormone-sensitive measures in this cohort.

Sign in / Sign up

Export Citation Format

Share Document