Novel bioactive materials developed by simulated body fluid evaluation: Surface-modified Ti metal and its alloys

2016 ◽  
Vol 44 ◽  
pp. 16-30 ◽  
Author(s):  
Tadashi Kokubo ◽  
Seiji Yamaguchi
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Bioactive Materials ◽  
Surface Modified

Surface Modification Of Polymers With Grafting And Coating Of Silane Hybrids And Their Bioactivity

1999 ◽  
Vol 576 ◽  
Author(s):  
Masaaki Kubo ◽  
Seisuke Takashima ◽  
Kanji Tsuru ◽  
Satoshi Hayakawa ◽  
Akiyoshi Osaka ◽  
...  
Keyword(s):  
Contact Angle ◽  
High Density Polyethylene ◽  
Body Fluid ◽  
Chemical Species ◽  
Hydrated Silica ◽  
Bioactive Materials ◽  
Poly Vinyl Chloride ◽  
Essential Chemical ◽  
Surface Modified

ABSTRACTHydrated silica rich Si-OH and Si-0- groups serve in a body environment as sites for nucleation of apatite, and are known as an essential chemical species for bioactive materials. Organic polymers having surface modified with the hydrated silica will show bioactivity: bone tissues grow toward the apatite layer and bond to materials. Thus MOPS-M (3-methacryloxypropyltrimethoxysilane) was grafted under emulsion polymerization procedure to high density polyethylene (HDPE), poly (vinyl chloride) (PVC) and polyamide (PA) substrates to examine in vitro deposition of apatite (bioactivity) after soaking in a simulated body fluid (Kokubo solution). Bioactivity was confirmed for the grafted PVC and PA substrates and discussed in terms of contact angle and relative amount of grafted silane molecules.

Corrosion behavior of surface-modified titanium in a simulated body fluid

2011 ◽  
Vol 46 (18) ◽  
pp. 5931-5939 ◽  
Author(s):  
Julia van Drunen ◽  
Baodong Zhao ◽  
Gregory Jerkiewicz
Keyword(s):  
Simulated Body Fluid ◽  
Corrosion Behavior ◽  
Body Fluid ◽  
Surface Modified

Apatite Formation on Zirconia (Y-TZP) Coated with Carbonate Apatite in Simulated Body Fluid

2019 ◽  
Vol 829 ◽  
pp. 145-150
Author(s):  
Astrie Yumeisa ◽  
Lisda Damayanti ◽  
Taufik Sumarsongko ◽  
Andrie Harmaji ◽  
Arief Cahyanto
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Bone Structure ◽  
Calcium Phosphates ◽  
Bone Defects ◽  
Control Group ◽  
Apatite Formation ◽  
Carbonate Apatite ◽  
Actin Ring ◽  
Bioactive Materials

Abstract. Various bioactive calcium phosphates such as hydroxyapatite (HA) and carbonate apatite (CO3Ap) have been widely studied due to their biocompatibility and osteoconductivity when implanted into bone defects. CO3Ap has the ability to adapt bone structure and induce bone regeneration; so that it can be categorized as resorbable bioactive materials. CO3Ap induced much stronger response such as cell adhesion and actin ring formation to osteoclast-like cells rather than HA. The aim of this study is to evaluate the bioactivity on zirconia (Y-TZP) coated with CO3Ap using simulated body fluid (SBF). Twenty Y-TZP ZrO2 disks with a 12-mm diameter and 1-mm thickness were employed as the samples. The disks were divided into two groups which the control group without CO3Ap coating and tested group with CO3Ap coating. Disks samples are dipped into CO3Ap suspension for one minute and stored in 37°C incubator for 24 hours. The disks were soaked in SBF for 1, 4, and 7 day(s) at 36.5°C. The obtained apatite crystals were characterized by scanning electron microscopy (SEM). It was found that the apatite formation on the tested group was greater than the control group. The EDS pattern showed the presence of Ca and P on the control and tested group after SBF soaking, which indicate the apatite deposition on the disks’ surface. However, the Ca and P on the tested group was higher compared to the control group. The formation of apatite layer on the disks’ surface is bioactivity indicator of CO3Ap.

Preparation of a Bioactive Xenograft

2007 ◽  
Vol 330-332 ◽  
pp. 99-102
Author(s):  
Hyung Sup Kim ◽  
Yong Keun Lee ◽  
Bum Soon Lim ◽  
Chong Pyong Chung ◽  
Sang Hoon Rhee
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
Size Range ◽  
Bovine Bone ◽  
Mixed Solution ◽  
Bioactive Materials ◽  
Carbonated Apatite ◽  
Heat Treated ◽  
New Process ◽  
Low Crystalline

The method which gives a low crystalline hydroxyl carbonated apatite forming ability to originally non-bioactive high crystalline hydroxyapatite surface was newly developed. The granules of trabecular bovine bone, which had a size range from 212 to 1000 μm, were defatted, deproteinized, and then heat-treated at 1000 oC for 3 hours to remove organics completely. They were treated with the mixed solution of calcium chloride and calcium hydroxide in Soxhlet’s apparatus at 100 oC for 3 days and then dried completely. Low crystalline hydroxyl carbonated apatite was observed to occur on the surface of high crystalline hydroxyapatite granules after soaking them into the simulated body fluid (SBF) for 1 week. This method is likely to have a potential to be used as a new process to give a bioactivity to originally non-bioactive materials.

In vitro mineralization of surface-modified porous polycaprolactone scaffolds in simulated body fluid

2008 ◽  
Vol 255 (2) ◽  
pp. 429-431 ◽  
Author(s):  
Chengyun Ning ◽  
Haimei Cheng ◽  
Wenjun Zhu ◽  
Zhaoyi Yin ◽  
Hao Chen ◽  
...  
Keyword(s):  
Simulated Body Fluid ◽  
Body Fluid ◽  
In Vitro Mineralization ◽  
Surface Modified

Formation of Hydroxyapatite on Titanium Oxides in Simulated Body Fluid under UV Irradiation

2010 ◽  
Vol 654-656 ◽  
pp. 2257-2260 ◽  
Author(s):  
Masato Ueda ◽  
Hiroki Sai ◽  
Masahiko Ikeda ◽  
Michiharu Ogawa
Keyword(s):  
Simulated Body Fluid ◽  
Uv Irradiation ◽  
Body Fluid ◽  
Uv Light ◽  
Titanium Oxides ◽  
Bioactive Materials ◽  
Hno3 Solution ◽  
Gel Layer ◽  
Tio2 Gel ◽  
Perovskite Type

Hydroxyapatite (HAp), Ca10(PO4)6(OH)2, is known to precipitate on bioactive materials by soaking in simulated body fluid (SBF). The formation of HAp on TiO2 and CaTiO3 surfaces under continuous ultraviolet (UV) irradiation was investigated in this study. Pure Ti substrates were chemically treated with H2O2/ HNO3 solution at 353 K for 20 min to form a TiO2 gel layer. The samples were then hydrothermally treated with an aqueous NH3 or an aqueous Ca(OH)2 solution in an autoclave at 453 K for 12 h. An adhesive and sufficiently crystallized anatase-type TiO2 film or perovskite-type CaTiO3 film could be synthesized on the Ti surface, respectively. The samples were immersed in SBF in darkness or under UV irradiation. The UV irradiation promoted the formation of HAp, which may be due to the generation of functional Ti-OH or Ti-O groups on both surfaces. On the other hand, the UV light also produces electron-hole pairs in the product films. In TiO2, much photogenerated holes migrated to the surface and repelled the Ca2+ ions in the solution. As a consequence, the UV irradiation suppressed the formation of HAp thin film on the surface of TiO2.

A Study on the Bioactivity of Nano-Titania/Hydroxyapatite Composite

2006 ◽  
Vol 309-311 ◽  
pp. 411-414 ◽  
Author(s):  
Bang Cheng Yang ◽  
Qi Feng Yu ◽  
Ji Yong Chen ◽  
Xing Dong Zhang
Keyword(s):  
Heat Treatment ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Apatite Formation ◽  
Bioactive Materials ◽  
Hydroxyapatite Composite

The bioactivity of a composite of titania and hydroxyapatite was studied in vitro in this paper. After the titania ceramics was added 10% HA, it could induce apatite formation in simulated body fluid in 2d, while the pure titania ceramics could not induced apatite formation even after 14d. After the composite of titania and HA was subjected to alkali-heat treatment, it has a faster speed for apatite formation in SBF than the composite without treatment. When the osteoblast was cultured on the materials, the amount of osteoblasts attaching on the composite was more than that on the pure titania ceramics. It has the most osteoblasts cells on the composite subjected to alkali-heat treatment. These results showed that the composite of titania and HA is a bioactive materials, while the alkali-heat treatment could improved the bioactivity of this composite.

IN-VITRO BEHAVIOUR OF BIPHASIC CALCIUM PHOSPHATE WITH DIFFERENT RATIO OF SILICA CONTENT IN SIMULATED BODY FLUID

2015 ◽  
Vol 23 (1) ◽  
pp. 1-14
Author(s):  
Sudirman Sahid ◽  
◽  
Nor Shahida Kader Bashah ◽  
Salina Sabudin ◽  
◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Biphasic Calcium Phosphate ◽  
Silica Content
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