In situ forming collagen–hyaluronic acid membrane structures: Mechanism of self-assembly and applications in regenerative medicine

2013 ◽  
Vol 9 (2) ◽  
pp. 5153-5161 ◽  
Author(s):  
Eun Ji Chung ◽  
Adam E. Jakus ◽  
Ramille N. Shah
Keyword(s):  
Hyaluronic Acid ◽  
Regenerative Medicine ◽  
Self Assembly ◽  
Membrane Structures ◽  
In Situ Forming

Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light

2017 ◽  
Vol 74 (10) ◽  
pp. 4069-4085 ◽  
Author(s):  
Takeshi Sato ◽  
Takao Aoyagi ◽  
Mitsuhiro Ebara ◽  
Rachel Auzély-Velty
Keyword(s):  
Hyaluronic Acid ◽  
Visible Light ◽  
Photo Oxidation ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

scholarly journals Fabrication of Injectable, Porous Hyaluronic Acid Hydrogel Based on an In-Situ Bubble-Forming Hydrogel Entrapment Process

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1138
Author(s):  
Lixuan Wang ◽  
Shiyan Dong ◽  
Yutong Liu ◽  
Yifan Ma ◽  
Jingjing Zhang ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Regenerative Medicine ◽  
In Vivo Studies ◽  
Injectable Hydrogels ◽  
Cell Behaviors ◽  
Porous Architecture ◽  
In Situ Hydrogel

Injectable hydrogels have been widely applied in the field of regenerative medicine. However, current techniques for injectable hydrogels are facing a challenge when trying to generate a biomimetic, porous architecture that is well-acknowledged to facilitate cell behaviors. In this study, an injectable, interconnected, porous hyaluronic acid (HA) hydrogel based on an in-situ bubble self-generation and entrapment process was developed. Through an amide reaction between HA and cystamine dihydrochloride activated by EDC/NHS, CO2 bubbles were generated and were subsequently entrapped inside the substrate due to a rapid gelation-induced retention effect. HA hydrogels with different molecular weights and concentrations were prepared and the effects of the hydrogel precursor solution’s concentration and viscosity on the properties of hydrogels were investigated. The results showed that HA10-10 (10 wt.%, MW 100,000 Da) and HA20-2.5 (2.5 wt.%, MW 200,000 Da) exhibited desirable gelation and obvious porous structure. Moreover, HA10-10 represented a high elastic modulus (32 kPa). According to the further in vitro and in vivo studies, all the hydrogels prepared in this study show favorable biocompatibility for desirable cell behaviors and mild host response. Overall, such an in-situ hydrogel with a self-forming bubble and entrapment strategy is believed to provide a robust and versatile platform to engineer injectable hydrogels for a variety of applications in tissue engineering, regenerative medicine, and personalized therapeutics.

In situ forming gelatin/hyaluronic acid hydrogel for tissue sealing and hemostasis

2019 ◽  
Vol 108 (3) ◽  
pp. 790-797
Author(s):  
Jing‐Wan Luo ◽  
Chang Liu ◽  
Jing‐Heng Wu ◽  
Dan‐Hui Zhao ◽  
Long‐Xiang Lin ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
In Situ Forming ◽  
Hyaluronic Acid Hydrogel ◽  
Tissue Sealing

In situ forming hydrogels of hyaluronic acid and inulin derivatives for cartilage regeneration

2015 ◽  
Vol 122 ◽  
pp. 408-416 ◽  
Author(s):  
Fabio S. Palumbo ◽  
Calogero Fiorica ◽  
Mauro Di Stefano ◽  
Giovanna Pitarresi ◽  
Alessandro Gulino ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cartilage Regeneration ◽  
In Situ Forming ◽  
In Situ Forming Hydrogels

scholarly journals Simultaneous Interpenetrating Polymer Network of Collagen and Hyaluronic Acid as an In Situ-Forming Corneal Defect Filler

2020 ◽  
Vol 32 (12) ◽  
pp. 5208-5216 ◽  
Author(s):  
Fang Chen ◽  
Peter Le ◽  
Krystal Lai ◽  
Gabriella M. Fernandes-Cunha ◽  
David Myung
Keyword(s):  
Hyaluronic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
In Situ Forming

A novel Na+coordination mediated supramolecular organogel based on isosteviol: water-assisted self-assembly, in situ forming and selective gelation abilities

Soft Matter ◽  
2013 ◽  
Vol 9 (3) ◽  
pp. 638-642 ◽  
Author(s):  
Tao Zhang ◽  
Ya Wu ◽  
Lihong Gao ◽  
Zhongtai Song ◽  
Li Zhao ◽  
...  
Keyword(s):  
Self Assembly ◽  
In Situ Forming

In situ forming interpenetrating hydrogels of hyaluronic acid hybridized with iron oxide nanoparticles

2015 ◽  
Vol 3 (11) ◽  
pp. 1466-1474 ◽  
Author(s):  
Malihe Kheirabadi ◽  
Liyang Shi ◽  
Reza Bagheri ◽  
Kourosh Kabiri ◽  
Jöns Hilborn ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
In Situ Forming ◽  
Aldehyde Groups ◽  
Derivatives Of

Four derivatives of hyaluronic acid (HA) bearing thiol (HA-SH), hydrazide (HA-hy), 2-dithiopyridyl (HA-SSPy), and aldehyde groups (HA-al) afford interpenetrating hydrogel in situ.

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