scholarly journals Enhanced angiogenesis by multiple release of platelet-rich plasma contents and basic fibroblast growth factor from gelatin hydrogels

2012 ◽  
Vol 8 (5) ◽  
pp. 1792-1801 ◽  
Author(s):  
Makoto Matsui ◽  
Yasuhiko Tabata
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Platelet Rich Plasma ◽  
Fibroblast Growth

Platelet-Rich Plasma with Basic Fibroblast Growth Factor for Treatment of Wrinkles and Depressed Areas of the Skin

2016 ◽  
Vol 137 (6) ◽  
pp. 1048e-1049e ◽  
Author(s):  
Barbara Hersant ◽  
Jeremy Niddam ◽  
Frederic Picard ◽  
Jonathan Bouhassira ◽  
Simone la Padula ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Platelet Rich Plasma ◽  
Fibroblast Growth ◽  
Treatment Of Wrinkles

Platelet-Rich Plasma with Basic Fibroblast Growth Factor for Treatment of Wrinkles and Depressed Areas of the Skin

2015 ◽  
Vol 136 (5) ◽  
pp. 931-939 ◽  
Author(s):  
Tatsuro Kamakura ◽  
Jiro Kataoka ◽  
Kazuhiko Maeda ◽  
Hideaki Teramachi ◽  
Hisayuki Mihara ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Platelet Rich Plasma ◽  
Fibroblast Growth ◽  
Treatment Of Wrinkles

scholarly journals Combined therapy of platelet-rich plasma and basic fibroblast growth factor using gelatin-hydrogel sheet for rotator cuff healing in rat models

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Takeshi Kataoka ◽  
Yutaka Mifune ◽  
Atsuyuki Inui ◽  
Hanako Nishimoto ◽  
Takashi Kurosawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Rotator Cuff ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Platelet Rich Plasma ◽  
Combined Therapy ◽  
Type Ii Collagen ◽  
Control Group ◽  
Fibroblast Growth ◽  
Gelatin Hydrogel

Abstract Introduction Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears and often occur in early postoperative phase. It was previously reported that basic fibroblast growth factor and platelet-rich plasma enhanced rotator cuff tear healing. We hypothesized that this combined therapy could enhance rotator cuff healing after rotator cuff repair in a rat model. This study aimed to evaluate the efficacy of combined therapy of platelet-rich plasma and basic fibroblast growth factor with gelatin-hydrogel sheet. Methods To create a rotator cuff defect, the infraspinatus tendon of Sprague Dawley rat was resected from the greater tuberosity. The infraspinatus tendons were repaired and covered with gelatin-hydrogel sheet impregnated with PBS (control group), basic fibroblast growth factor (bFGF group), platelet-rich plasma (PRP group), or both basic fibroblast growth factor and platelet-rich plasma (combined group). Histological examinations were conducted using hematoxylin and eosin, safranin O, and immunofluorescence staining, such as Isolectin B4, type II collagen at 2 weeks postoperatively. For mechanical analysis, ultimate failure load of the tendon-humeral head complex was evaluated at 6 weeks postoperatively. Results In the hematoxylin and eosin staining, the tendon maturing score of the combined group was higher than that of the control group at postoperative 2 weeks. In the safranin O staining, stronger proteoglycan staining was observed in the combined group compared with the other groups at postoperative 2 weeks. Vascular staining with isolectin B4 in 3 treatment groups was significantly higher than that in the control group. Type II collagen expression in the combined group was significantly higher than those in the other groups. The ultimate failure load of the combined group was significantly higher than that of the control group. Conclusion Combined therapy of basic fibroblast growth factor and platelet-rich plasma promoted angiogenesis, tendon maturing and fibrocartilage regeneration at the enthesis, which could enhance the mechanical strength. It was suggested that combined basic fibroblast growth factor and platelet-rich plasma might enhance both tendon and bone–tendon junction healing, and basic fibroblast growth factor and platelet-rich plasma might be synergistic.

scholarly journals Combined Therapy of Platelet-Rich Plasma and Basic Fibroblast Growth Factor Using Gelatin-Hydrogel Sheet for Rotator Cuff Healing in Rat Models

2021 ◽  
Author(s):  
Takeshi Kataoka ◽  
Yutaka Mifune ◽  
Atsuyuki Inui ◽  
Hanako Nishimoto ◽  
Takashi Kurosawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Rotator Cuff ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Platelet Rich Plasma ◽  
Combined Therapy ◽  
Control Group ◽  
Fibroblast Growth ◽  
Gelatin Hydrogel ◽  
Safranin O

Abstract Introduction: Excellent outcomes of arthroscopic rotator cuff repair for small and medium tears have been recently reported. However, re-tears after surgery have been a common complication after surgical repair of large and massive rotator cuff tears andoften occur in early postoperative phase. It was previously reported that basic fibroblastgrowth factor and platelet-rich plasma enhanced rotator cuff tear healing. Wehypothesized that this combined therapy could enhance rotator cuff healing after rotatorcuff repair in a rat model. This study aimed to evaluate the efficacy of combined therapyof platelet-rich plasma and basic fibroblast growth factor with gelatin-hydrogel sheet.Methods: To create a rotator cuff defect, the infraspinatus tendon of Sprague Dawley ratwas resected from the greater tuberosity. The infraspinatus tendons were repaired andcovered with gelatin-hydrogel sheet impregnated with PBS (control group), basicfibroblast growth factor (bFGF group), platelet-rich plasma (PRP group), or both basicfibroblast growth factor and platelet-rich plasma (combined group). Histologicalexaminations were conducted using hematoxylin and eosin, safranin O, andimmunofluorescence staining such as Isolectin B4, type II collagen. For mechanicalanalysis, ultimate failure load of the tendon-humeral head complex was evaluated at41 weeks postoperatively.Results: In the hematoxylin and eosin staining, the tendon maturing score of the combined group was higher than that of the control group postoperativeat 2 weeks. Inthe safranin O staining, stronger proteoglycan staining was observed in the combinedgroup compared with the other groups at postoperative 2 weeks. Vascular staining withisolectin B4 in 3 treatment groups was significantly higher than that in the control group.Type II collagen expression in the combined group was significantly higher than those inthe other groups. The ultimate failure load of the combined group was significantly higherthan that of the control group.Conclusion: Combined therapy of basic fibroblast growth factor and platelet-rich plasmapromoted angiogenesis; tendon maturing and fibrocartilage regeneration at the enthesis,which could be enhance the mechanical strength. It was suggested that basic fibroblastgrowth factor and platelet-rich plasma enhance both tendon and bone-tendon junctionhealing, and basic fibroblast growth factor and platelet-rich plasma were synergistic.

A Case of Contact Dermatitis due to Fiblast Spray, a Product of Basic Fibroblast Growth Factor

2006 ◽  
Vol 68 (3) ◽  
pp. 248-250 ◽  
Author(s):  
Shuko OKADA ◽  
Takashi MASU ◽  
Takahiko TSUNODA ◽  
Ryuhei OKUYAMA ◽  
Setsuya AIBA
Keyword(s):  
Contact Dermatitis ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Basic Fibroblast Growth Factor ◽  
Fibroblast Growth
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