scholarly journals Long-term culture of HL-1 cardiomyocytes in modular poly(ethylene glycol) microsphere-based scaffolds crosslinked in the phase-separated state

2012 ◽  
Vol 8 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Amanda W. Smith ◽  
Claire E. Segar ◽  
Peter K. Nguyen ◽  
Matthew R. MacEwan ◽  
Igor R. Efimov ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Long Term Culture ◽  
Poly Ethylene

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Poly(ethylene glycol)-Conjugation and Deoxygenation Enable Long-Term Preservation of Hemoglobin-Vesicles as Oxygen Carriers in a Liquid State

2000 ◽  
Vol 11 (3) ◽  
pp. 425-432 ◽  
Author(s):  
Hiromi Sakai ◽  
Ken-ichi Tomiyama ◽  
Keitaro Sou ◽  
Shinji Takeoka ◽  
Eishun Tsuchida
Keyword(s):  
Ethylene Glycol ◽  
Liquid State ◽  
Oxygen Carriers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Long Term Preservation

scholarly journals Long-Term Controlled Protein Release from Poly(Ethylene Glycol) Hydrogels by Modulating Mesh Size and Degradation

2015 ◽  
Vol 15 (12) ◽  
pp. 1679-1686 ◽  
Author(s):  
Xinming Tong ◽  
Soah Lee ◽  
Layla Bararpour ◽  
Fan Yang
Keyword(s):  
Ethylene Glycol ◽  
Mesh Size ◽  
Protein Release ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

scholarly journals Protein delivery nanosystem of six-arm copolymer poly(ε-caprolactone)–poly(ethylene glycol) for long-term sustained release

2018 ◽  
Vol Volume 13 ◽  
pp. 2743-2754 ◽  
Author(s):  
Jianwei Duan ◽  
Chao Liu ◽  
Xiaoyu Liang ◽  
Xuanling Li ◽  
Youlu Chen ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Sustained Release ◽  
Protein Delivery ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Copolymer Poly

Short-term adhesion and long-term biofouling testing of polydopamine and poly(ethylene glycol) surface modifications of membranes and feed spacers for biofouling control

2012 ◽  
Vol 46 (12) ◽  
pp. 3737-3753 ◽  
Author(s):  
Daniel J. Miller ◽  
Paula A. Araújo ◽  
Patricia B. Correia ◽  
Matthew M. Ramsey ◽  
Joop C. Kruithof ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Modifications ◽  
Poly Ethylene Glycol ◽  
Short Term ◽  
Biofouling Control ◽  
Poly Ethylene
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