scholarly journals Development and performance of a 3D-printable poly(ethylene glycol) diacrylate hydrogel suitable for enzyme entrapment and long-term biocatalytic applications

2018 ◽  
Vol 18 (9) ◽  
pp. 659-667 ◽  
Author(s):  
Barbara Schmieg ◽  
Adrian Schimek ◽  
Matthias Franzreb
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene ◽  
And Performance ◽  
Enzyme Entrapment

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

scholarly journals Gel Polymer Electrolytes Based on Cross-Linked Poly(ethylene glycol) Diacrylate for Calcium-Ion Conduction

ACS Omega ◽  
2021 ◽  
Author(s):  
Saeid Biria ◽  
Shreyas Pathreeker ◽  
Francielli S. Genier ◽  
Fu-Hao Chen ◽  
Hansheng Li ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Polymer Electrolytes ◽  
Calcium Ion ◽  
Gel Polymer Electrolytes ◽  
Poly Ethylene Glycol ◽  
Ion Conduction ◽  
Glycol Diacrylate ◽  
Poly Ethylene

Effects of pore morphology and size on antimicrobial activity of chitosan/poly(ethylene glycol) diacrylate macromer semi-IPN hydrogels

2015 ◽  
Vol 132 (43) ◽  
pp. n/a-n/a ◽  
Author(s):  
Nazlı Sokmen Bedel ◽  
Melek Tezcan ◽  
Ozgur Ceylan ◽  
Gulten Gurdag ◽  
Huseyin Cicek
Keyword(s):  
Antimicrobial Activity ◽  
Ethylene Glycol ◽  
Pore Morphology ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Poly Ethylene
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