In vitro and in vivo degradation profile of aliphatic polyesters subjected to electron beam sterilization

2011 ◽  
Vol 7 (5) ◽  
pp. 2035-2046 ◽  
Author(s):  
S. Dånmark ◽  
A. Finne-Wistrand ◽  
K. Schander ◽  
M. Hakkarainen ◽  
K. Arvidson ◽  
...  
Keyword(s):  
Electron Beam ◽  
Aliphatic Polyesters ◽  
In Vivo Degradation

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

In vitro and in vivo degradation of silk fibers degummed with various sodium carbonate concentrations

2021 ◽  
Vol 27 ◽  
pp. 102369
Author(s):  
Shijun Lu ◽  
Xiaochen Tang ◽  
Qingqing Lu ◽  
Jiwei Huang ◽  
Xinran You ◽  
...  
Keyword(s):  
Sodium Carbonate ◽  
Silk Fibers ◽  
In Vivo Degradation

Porous-conductive chitosan scaffolds for tissue engineering II. in vitro and in vivo degradation

2005 ◽  
Vol 16 (11) ◽  
pp. 1017-1028 ◽  
Author(s):  
Ying Wan ◽  
Aixi Yu ◽  
Hua Wu ◽  
Zhaoxu Wang ◽  
Dijiang Wen
Keyword(s):  
Tissue Engineering ◽  
Chitosan Scaffolds ◽  
In Vivo Degradation

In Vitro and In Vivo Degradation, Mechanical Properties, and Histocompatibility of Weft-Knitted Silk Mesh-Like Grafts

2022 ◽  
Vol 12 (2) ◽  
pp. 411-416
Author(s):  
Liang Tang ◽  
Si-Yu Zhao ◽  
Ya-Dong Yang ◽  
Geng Yang ◽  
Wen-Yuan Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Degradation Rate ◽  
Maximum Load ◽  
Artificial Ligament ◽  
In Vivo Degradation

To investigate the degradation, mechanical properties, and histocompatibility of weft-knitted silk mesh-like grafts, we carried out the In Vitro and In Vivo silk grafts degradation assay. The In Vitro degradation experiment was performed by immersing the silk grafts in simulated body fluid for 1 year, and the results showed that the degradation rate of the silk mesh-like grafts was very slow, and there were few changes in the mechanical properties and quality of the silk mesh-like graft. In Vivo degradation assay was taken by implantation of the silk mesh-like grafts into the subcutaneous muscles of rabbits. At 3, 6, and 12 months postoperation, the rate of mass loss was 19.36%, 31.84%, and 58.77%, respectively, and the maximum load was 63.85%, 34.63%, and 10.76%, respectively of that prior to degradation. The results showed that the degradation rate of the silk graft and the loss of mechanical properties In Vivo were faster than the results obtained in the In Vitro experiments. In addition, there were no significant differences in secretion of serum IL-6 and TNF-α between the experimental and normal rabbits (P >0.05), suggesting no obvious inflammatory reaction. The findings suggest that the weft-knitted silk mesh-like grafts have good mechanical properties, histocompatibility, and In Vivo degradation rate, and therefore represent a candidate material for artificial ligament

Effects of multiscale porosity and pore interconnectivity on in vitro and in vivo degradation and biocompatibility of Fe-Mn-Cu scaffold

2021 ◽  
Author(s):  
Santanu Mandal ◽  
Viraj Rathod ◽  
Samit Kumar Nandi ◽  
Mangal Roy
Keyword(s):  
High Strength ◽  
Pore Interconnectivity ◽  
In Vivo Degradation

Iron (Fe) based scaffolds are promising candidates as degradable metallic scaffolds. High strength and ability to control the degradation with tailormade composition and porosity are specific advantages of these scaffolds....

Visualization of in vivo degradation of aliphatic polyesters by a fluorescent dendritic star macromolecule

2015 ◽  
Vol 10 (6) ◽  
pp. 065003 ◽  
Author(s):  
Shun Duan ◽  
Shiqing Ma ◽  
Zhaohui Huang ◽  
Xu Zhang ◽  
Xiaoping Yang ◽  
...  
Keyword(s):  
Aliphatic Polyesters ◽  
In Vivo Degradation

scholarly journals Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds

2015 ◽  
Vol 30 (4) ◽  
pp. 435-449 ◽  
Author(s):  
Benedikt L Proffen ◽  
Gabriel S Perrone ◽  
Braden C Fleming ◽  
Jakob T Sieker ◽  
Joshua Kramer ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Electron Beam ◽  
Low Temperature ◽  
Ethylene Oxide
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