Effects of multiscale porosity and pore interconnectivity on in vitro and in vivo degradation and biocompatibility of Fe-Mn-Cu scaffold

2021 ◽  
Author(s):  
Santanu Mandal ◽  
Viraj Rathod ◽  
Samit Kumar Nandi ◽  
Mangal Roy
Keyword(s):  
High Strength ◽  
Pore Interconnectivity ◽  
In Vivo Degradation

Iron (Fe) based scaffolds are promising candidates as degradable metallic scaffolds. High strength and ability to control the degradation with tailormade composition and porosity are specific advantages of these scaffolds....

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

In vitro and in vivo degradation of silk fibers degummed with various sodium carbonate concentrations

2021 ◽  
Vol 27 ◽  
pp. 102369
Author(s):  
Shijun Lu ◽  
Xiaochen Tang ◽  
Qingqing Lu ◽  
Jiwei Huang ◽  
Xinran You ◽  
...  
Keyword(s):  
Sodium Carbonate ◽  
Silk Fibers ◽  
In Vivo Degradation

Porous-conductive chitosan scaffolds for tissue engineering II. in vitro and in vivo degradation

2005 ◽  
Vol 16 (11) ◽  
pp. 1017-1028 ◽  
Author(s):  
Ying Wan ◽  
Aixi Yu ◽  
Hua Wu ◽  
Zhaoxu Wang ◽  
Dijiang Wen
Keyword(s):  
Tissue Engineering ◽  
Chitosan Scaffolds ◽  
In Vivo Degradation

In Vitro and In Vivo Degradation, Mechanical Properties, and Histocompatibility of Weft-Knitted Silk Mesh-Like Grafts

2022 ◽  
Vol 12 (2) ◽  
pp. 411-416
Author(s):  
Liang Tang ◽  
Si-Yu Zhao ◽  
Ya-Dong Yang ◽  
Geng Yang ◽  
Wen-Yuan Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Simulated Body Fluid ◽  
Body Fluid ◽  
Degradation Rate ◽  
Maximum Load ◽  
Artificial Ligament ◽  
In Vivo Degradation

To investigate the degradation, mechanical properties, and histocompatibility of weft-knitted silk mesh-like grafts, we carried out the In Vitro and In Vivo silk grafts degradation assay. The In Vitro degradation experiment was performed by immersing the silk grafts in simulated body fluid for 1 year, and the results showed that the degradation rate of the silk mesh-like grafts was very slow, and there were few changes in the mechanical properties and quality of the silk mesh-like graft. In Vivo degradation assay was taken by implantation of the silk mesh-like grafts into the subcutaneous muscles of rabbits. At 3, 6, and 12 months postoperation, the rate of mass loss was 19.36%, 31.84%, and 58.77%, respectively, and the maximum load was 63.85%, 34.63%, and 10.76%, respectively of that prior to degradation. The results showed that the degradation rate of the silk graft and the loss of mechanical properties In Vivo were faster than the results obtained in the In Vitro experiments. In addition, there were no significant differences in secretion of serum IL-6 and TNF-α between the experimental and normal rabbits (P >0.05), suggesting no obvious inflammatory reaction. The findings suggest that the weft-knitted silk mesh-like grafts have good mechanical properties, histocompatibility, and In Vivo degradation rate, and therefore represent a candidate material for artificial ligament

UV Activated Copolymerization Coatings of Urethane Acrylates for Use in the Cosmetic Industry

2021 ◽  
Author(s):  
◽  
Zane Grigale-Soročina
Keyword(s):  
Color Constancy ◽  
Surface Hardness ◽  
High Strength ◽  
Polymerization Process ◽  
Component Selection ◽  
Materials Used ◽  
Pigmented Coatings

In the dissertation compositions of urethane diacrylates and monoacrylates have been studied, which when curing under the conditions of UV-activated copolymerization process meeting the requirements of cosmetic varnishes, form cross-linked structure coatings with high strength-deformation, surface hardness, surface light reflectance, adhesion and other parameters. The review of the literature summarizes information on the types of natural nail coatings and the basic components entering them. Restrictions on the choice of basic components entering the system are described. The effect of conditions and components on the natural nail is described. The materials used in the research are described in the methodological part of the work. The process of obtaining compositions is described. The research methods used are described: characterization of rheological properties of non-polymerized compositions, differential thermal analysis of polymerization process, determination of polymerization depth, determination of crosslinked part of polymerized systems, determination of yield tensile strength-deformation, coating surface hardness, surface gloss and surface wear, assessment of adhesion and its durability, in-vitro and in-vivo coating adhesion studies on natural nails, spectroscopic analysis of pigmented coatings and assessment of color constancy, comparison of coating compositions in terms of their functionality and effects on human health. In the experimental part of the work, methodologies for component selection, composite system formation and obtaining appropriate coatings have been developed. A methodology has been developed for the evaluation of the set of structures and properties of the obtained coatings. The influence of the chemical nature and content ratios of urethane diacrylates and monoacrylates suitable for the formation of separate cosmetic coatings on the indicators of cross-linked structures formed in the process of UV-activated copolymerization and the corresponding indicators of coating properties has been studied. The influence of individual additives on the properties of cross-linked coatings, their adhesion to the surface and the durability of the coating at removal process has been evaluated.

scholarly journals Monolithic Zirconia: An Update to Current Knowledge. Optical Properties, Wear, and Clinical Performance

2019 ◽  
Vol 7 (3) ◽  
pp. 90 ◽  
Author(s):  
Eleana Kontonasaki ◽  
Athanasios E. Rigos ◽  
Charithea Ilia ◽  
Thomas Istantsos
Keyword(s):  
Clinical Performance ◽  
Current Knowledge ◽  
High Strength ◽  
Wear Properties ◽  
Zirconia Ceramics ◽  
Term Survival ◽  
Monolithic Zirconia

The purpose of this paper was to update the knowledge concerning the wear, translucency, as well as clinical performance of monolithic zirconia ceramics, aiming at highlighting their advantages and weaknesses through data presented in recent literature. New ultra-translucent and multicolor monolithic zirconia ceramics present considerably improved aesthetics and translucency, which, according to the literature reviewed, is similar to those of the more translucent lithium disilicate ceramics. A profound advantage is their high strength at thin geometries preserving their mechanical integrity. Based on the reviewed articles, monolithic zirconia ceramics cause minimal wear of antagonists, especially if appropriately polished, although no evidence still exists regarding the ultra-translucent compositions. Concerning the survival of monolithic zirconia restorations, the present review demonstrates the findings of the existing short-term studies, which reveal promising results after evaluating their performance for up to 5 or 7 years. Although a significant increase in translucency has been achieved, new translucent monolithic zirconia ceramics have to be further evaluated both in vitro and in vivo for their long-term potential to preserve their outstanding properties. Due to limited studies evaluating the wear properties of ultra-translucent material, no sound conclusions can be made, whereas well-designed clinical studies are urgently needed to enlighten issues of prognosis and long-term survival.

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