Structural and Functional Characterization of Chronic Obstructive Lung Disease and Emphysema Using 3He- MRI: Comparison with CT and Pulmonary Function Tests

2005 ◽  
Vol 12 (5) ◽  
pp. S69-S70
Author(s):  
Hans-Ulrich Kauczor ◽  
Sebastian Ley ◽  
Klaus Gast ◽  
Alexander Biedermann ◽  
Julia Zaporozhan ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Pulmonary Function Tests ◽  
Functional Characterization ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Function Tests

Nutritional and pulmonary function assessment in patients with chronic obstructive lung disease

1981 ◽  
Vol 1 (5) ◽  
pp. 461-466 ◽  
Author(s):  
Mary Therse Hynak ◽  
Mohamed S. Al-Ibrahim ◽  
Robert M. Russell ◽  
Gina Stanko ◽  
C.V.J. Verghease ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Function Assessment

scholarly journals Vitamin D Deficiency and Chronic Lung Disease

2009 ◽  
Vol 16 (3) ◽  
pp. 75-80 ◽  
Author(s):  
Christopher R Gilbert ◽  
Seth M Arum ◽  
Cecilia M Smith
Keyword(s):  
Vitamin D ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Vitamin D Deficiency ◽  
Chronic Lung Disease ◽  
Obstructive Lung Disease ◽  
Lung Diseases ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Chronic Lung Diseases

Vitamin D deficiency is increasingly being recognized as a prevalent problem in the general population. Patients with chronic lung diseases such as asthma, cystic fibrosis, chronic obstructive lung disease and interstitial pneumonia appear to be at increased risk for vitamin D deficiency for reasons that are not clear.Several studies indicate that vitamin D possesses a range of anti-inflammatory properties and may be involved in processes other than the previously believed functions of calcium and phosphate homeostasis. Various cytokines, cellular elements, oxidative stress and protease/antiprotease levels appear to affect lung fibroproliferation, remodelling and function, which may be influenced by vitamin D levels. Chronic lung diseases such as asthma and chronic obstructive lung disease have also been linked to vitamin D on a genetic basis. This immune and genetic influence of vitamin D may influence the pathogenesis of chronic lung diseases. A recent observational study notes a significant association between vitamin D deficiency and decreased pulmonary function tests in a large ambulatory population.The present review will examine the current literature regarding vitamin D deficiency, its prevalence in patients with chronic lung disease, vitamin D anti-inflammatory properties and the role of vitamin D in pulmonary function.

A Double-Blind Parallel Study of Acetylcysteine-Isoproterenol and Saline-Isoproterenol in Patients with Chronic Obstructive Lung Disease

1977 ◽  
Vol 5 (3) ◽  
pp. 175-183 ◽  
Author(s):  
Allen Cato ◽  
Ira Goldstein ◽  
Milton Millman
Keyword(s):  
Side Effects ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Chronic Obstructive Lung Disease ◽  
Chronic Obstructive ◽  
Parallel Study ◽  
Double Blind ◽  
Safety And Efficacy ◽  
Pre Treatment

A double-blind parallel study in patients with asthma compared the safety and efficacy of saline-isoproterenol (SI) and acetylcysteine-isoproterenol (AI), when administered at home as an aerosol, over a one-week period, using a conventional nebulizer compressor. Measurements of pulmonary function revealed statistically significant differences between the two therapies for FEV1 and FVC in favour of AI. In the group treated with AI, the average sputum viscosity after six days of treatment was significantly less than pre-treatment values, or when compared to the results with SI treatment. No serious side-effects were reported during treatment with either therapy. These results indicate that acetylcysteine combined with a bronchodilator, such as isoproterenol, may be safe and of significant value in the treatment of patients with asthma who are also sputum producers.

scholarly journals Pulmonary ventilation defects in older never-smokers

2014 ◽  
Vol 117 (3) ◽  
pp. 297-306 ◽  
Author(s):  
Khadija Sheikh ◽  
Gregory A. Paulin ◽  
Sarah Svenningsen ◽  
Miranda Kirby ◽  
Nigel A. M. Paterson ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Pulmonary Function Tests ◽  
Pulmonary Ventilation ◽  
Forced Expiratory Volume ◽  
Airflow Limitation ◽  
Second Hand Smoke ◽  
Chronic Obstructive ◽  
Never Smokers

Hyperpolarized 3He MRI previously revealed spatially persistent ventilation defects in healthy, older compared with healthy, younger never-smokers. To understand better the physiological consequences and potential relevance of 3He MRI ventilation defects, we evaluated 3He-MRI ventilation-defect percent (VDP) and the effect of deep inspiration (DI) and salbutamol on VDP in older never-smokers. To identify the potential determinants of ventilation defects in these subjects, we evaluated dyspnea, pulmonary function, and cardiopulmonary exercise test (CPET) measurements, as well as occupational and second-hand smoke exposure. Fifty-two never-smokers (71 ± 6 yr) with no history of chronic respiratory disease were evaluated. During a single visit, pulmonary function tests, CPET, and 3He MRI were performed and the Burden of Obstructive Lung Disease questionnaire administered. For eight of 52 subjects, there was spirometry evidence of airflow limitation (Global Initiative for Chronic Obstructive Lung Disease-Unclassified, I, and II), and occupational exposure was reported in 13 of 52 subjects. In 13 of 52 (25%) subjects, there were no ventilation defects and in 39 of 52 (75%) subjects, ventilation defects were observed. For those subjects with ventilation defects, six of 39 showed a VDP response to DI/salbutamol. Ventilation heterogeneity and VDP were significantly greater, and forced expiratory volume in 1 s (FEV1)/forced vital capacity was significantly lower ( P < 0.05) for subjects with ventilation defects with a response to DI/salbutamol than subjects with ventilation defects without a response to DI/salbutamol and subjects without ventilation defects. In a step-wise, forward multivariate model, FEV1, inspiratory capacity, and airway resistance significantly predicted VDP ( R2 = 0.45, P < 0.001). In conclusion, most never-smokers had normal spirometry and peripheral ventilation defects not reversed by DI/salbutamol; such ventilation defects were likely related to irreversible airway narrowing/collapse but not to dyspnea and decreased exercise capacity.

IS ETHNICITY MORE ASSOCIATED WITH ASTHMA OR COPD? A STUDY OF INNER CITY NEW YORKERS WITH A DIAGNOSIS OF OBSTRUCTIVE LUNG DISEASE REFERRED FOR PULMONARY FUNCTION TESTS

CHEST Journal ◽  
2009 ◽  
Vol 136 (4) ◽  
pp. 7S
Author(s):  
Cristina Gutierrez ◽  
Sucheta Pai ◽  
Miriam Lagunas-Fitta ◽  
Veronica Fusco-Garcia ◽  
Balavenkatesh Kanna ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Inner City ◽  
Lung Disease ◽  
Obstructive Lung Disease ◽  
Pulmonary Function Tests ◽  
Function Tests ◽  
New Yorkers
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